Circadian regulation in the retina: From molecules to network

Ko, Gladys Y.-P.

doi:10.1111/ejn.14185

Cited by 50 publications

(45 citation statements)

References 305 publications

(464 reference statements)

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“…Research supporting circadian regulation in these regions is described below in sections ordered by the five primary brain divisions. It is also important to note that an overview of the retina is not included below because the importance of the retinal circadian clock is covered elsewhere in this Special Issue (Ko, ).…”

Section: Suprachiasmatic Nucleus Of the Hypothalamusmentioning

confidence: 99%

Circadian regulation of membrane physiology in neural oscillators throughout the brain

Paul

Davis

Goode

et al. 2019

Eur J of Neuroscience

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Twenty‐four‐hour rhythmicity in physiology and behavior are driven by changes in neurophysiological activity that vary across the light–dark and rest‐activity cycle. Although this neural code is most prominent in neurons of the primary circadian pacemaker in the suprachiasmatic nucleus (SCN) of the hypothalamus, there are many other regions in the brain where region‐specific function and behavioral rhythmicity may be encoded by changes in electrical properties of those neurons. In this review, we explore the existing evidence for molecular clocks and/or neurophysiological rhythms (i.e., 24 hr) in brain regions outside the SCN. In addition, we highlight the brain regions that are ripe for future investigation into the critical role of circadian rhythmicity for local oscillators. For example, the cerebellum expresses rhythmicity in over 2,000 gene transcripts, and yet we know very little about how circadian regulation drives 24‐hr changes in the neural coding responsible for motor coordination. Finally, we conclude with a discussion of how our understanding of circadian regulation of electrical properties may yield insight into disease mechanisms which may lead to novel chronotherapeutic strategies in the future.

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Section: Suprachiasmatic Nucleus Of the Hypothalamusmentioning

confidence: 99%

Circadian regulation of membrane physiology in neural oscillators throughout the brain

Paul

Davis

Goode

et al. 2019

Eur J of Neuroscience

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“…The retina is a part of the central nervous system (CNS) and perceived as a "window to the brain" [4] in establishing similarities in the physiology and function of the CNS [5]. The retina also contains a circadian rhythm, and several studies have identified that many aspects of retinal physiology and functions are under the control of a retinal circadian system [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…The release of the two primary neurotransmitters, dopamine (DA) and melatonin (MLT), provide the "day" and "night" signals in the retina, which reconfigure retinal circuits and shape the functioning of the retina according to the time of the day [6,9]. Dysfunction of the circadian rhythm within the retina affects adversely the retinal function in the processing of the light information, synaptic communication, and metabolism [8].…”

Section: Introductionmentioning

confidence: 99%

Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer

et al. 2020

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Sleep may play a fundamental role in retinal regulation and the degree of retinal variables. However, no clinical study has investigated optical coherence tomography (OCT) parameters in patients with primary insomnia. All participants were evaluated with the insomnia severity index (ISI) and the Pittsburgh sleep quality index (PSQI). The retinal nerve fiber layer (RNFL), ganglion cell layer (GC), inner plexiform layer (IPL), macula and choroidal (CH) thickness were compared between 52 drug-naïve patients with primary insomnia and 45 age-gender-BMI-smoke status matched healthy controls (HC). The patients with primary insomnia differed from the HC regarding RNFL-Global (p = 0.024) and RNFL-Nasal inferior (p = 0.010); IPL-Temporal (p < 0.001), IPL-Nasal (p < 0.001); CH-Global (p < 0.001), CH-Temporal (p = 0.004), CH-Nasal (p < 0.001), and CH-Fovea (p = 0.019). ISI correlated with RNFL-Global and RNFL-Nasal inferior. The regression analysis revealed that ISI was the significant predictor for the thickness of RNFL- Nasal inferior (p = 0.020), RNFL-Global (p = 0.031), and CH-Nasal (p = 0.035) in patients with primary insomnia. Sleep disorders are seen commonly in patients with psychiatric, including ocular diseases. Adjusting the effect of insomnia can help to clarify the consistency in findings of OCT.

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“…Importantly, the various cells of the retina and the retinal pigment epithelium themselves each bear circadian oscillators that communicate via synapses, gap junctions and released neurochemicals that can diffuse in the extracellular space outside of synapses. The consensus in the literature on the ways in which circadian signals are integrated in this highly organized retinal tissue is summarized in the paper by Ko ().…”

Section: Extra‐scn Oscillatorsmentioning

confidence: 99%

Circadian rhythmicity and the community of clockworkers

Gamble

Silver

2019

Eur J of Neuroscience

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ReviewCauston, Helen C. Metab olic rhyth ms: A frame work for coord inati ng cellu lar function Golden, Susan S. Princ iples of rhyth micit y emerg ing from cyano bacteria Loros, Jennifer J. Princ iples of the anima l molec ular clock learn ed from Neuro spora Circadian rhythms in complex systems Exp't Gillette, Martha U. Circa dian rhyth m of redox state regul ates membr ane excit abili ty in hippo campa l CA1 neurons Prosser, Rebecca A. Coppe r in the supra chias matic circa dian clock : A possi ble link betwe en multi ple circa dian oscil lators Silver, Rae Overe xpres sion of stria tal D2 recep tors reduc es motiv ation there by decre asing food antic ipato ry activity Stengl, Monika Circa dian pacem aker neuro ns of the Madei ra cockr oach are inhib ited and activ ated by GABAA and GABAB recep tors Review Evans, Jennifer A. Circu it devel opmen t in the maste r clock netwo rk of mammals Gamble, Karen L. Circa dian regul ation of membr ane physi ology in neura l oscil lator s throu ghout the brain Green, Carla B. Perio dicit y, repre ssion , and the molec ular archi tectu re of the mamma lian circa dian clock Helfrich-Föerster, Charlotte Flies as model s for circa dian clock adapt ation to envir onmen tal chall enges Honma, Sato Devel opmen t of the mamma lian circa dian clock Ko, Gladys Y.-P. Circa dian regul ation in the retin a: From molec ules to network Mahoney, Megan M. Modul ation of circa dian rhyth ms throu gh estro gen recep tor signa ling Maywood, Elizabeth S. Synch roniz ation and maint enanc e of circa dian timin g in the mamma lian clock work Mongrain, Valérie Trans cript ional contr ol of synap tic compo nents by the clock machi nery Sehgal, Amita Molec ular and circu it mecha nisms media ting circa dian clock outpu t in the Droso phila brain Sumová, Alena Myste ry of rhyth mic signa l emerg ence withi n the supra chias matic nuclei Clocks in health and disruption Exp't Harrington, Mary E. Recur ring circa dian disru ption alter s circa dian clock sensi tivit y to reset ting Martha Merrow Strat egies to decre ase socia l jetla g: Reduc ing eveni ng blue light advan ces sleep and melat onin Skene, Debra J. Effec t of acute total sleep depri vatio n on plasm a melat onin, corti sol and metab olite rhyth ms in females Review Boivin, Diane B. Metab olic and cardi ovasc ular conse quenc es of shift work: The role of circa dian disru ption and sleep distu rbances Cirelli, Chiara Sleep and synap tic down-selec tion Duncan, Marilyn J. Inter actin g influ ences of aging and Alzhe imer's disea se on circa dian rhythms Fu, Ying-Hui The molec ular genet ics of human sleep González-Mariscal, Gabriela Behav ioral , neuro endoc rine and physi ologi cal indic ators of the circa dian biolo gy of male and femal e rabbits Lyons, Lisa C. Aging and the clock : Persp ectiv e from flies to humans McClung, Colleen A. Mood-relat ed centr al and perip heral clocks Meijer, Johanna H. From clock to funct ional pacem aker Shirasu-Hiza, Mimi Tired and stres sed: Exami ning the need for sleep Simonneaux, Valérie A Kiss to dr...

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Circadian regulation in the retina: From molecules to network

Cited by 50 publications

References 305 publications

Circadian regulation of membrane physiology in neural oscillators throughout the brain

Circadian regulation of membrane physiology in neural oscillators throughout the brain

Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer

Circadian rhythmicity and the community of clockworkers

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