The resilience and deformability of articular cartilage facilitate the bone-to-bone movement. Articular cartilage has neither nerves nor blood vessels. The nutrition is mainly supplied by the synovial fluid and arterial branches surrounding the synovial layer of the capsule. Chondrocytes are scattered between the collagen fibers and are responsible for the metabolism of cartilage. In osteoarthritis (OA), chondrocytes become incapacitated to maintain a balance between synthesis and degradation of the matrix, resulting in its irreversible destruction. 1 Circadian cycle regulates several biological processes in living systems. Disturbances in which can lead to increased risk of diseases. 2 In recent years, our understanding of OA is no longer limited only to the influence of inflammation and immune system; but other aspects such as central nervous system, cellular metabolism, circadian rhythm, and intestinal microbiota have also gained importance to develop the novel targets for future research. 3,4 Multiple reviews have elaborated on the role of biological clocks in the maturation