Circadian oscillation in the intestinal expression of OCTN1/SLC22A4 underlies the dosing time-dependent changes in the absorption of pregabalin and its analgesic effects on diabetic neuropathy

Koyanagi, Satoru; Akamine, Takuya; Wada, Erika; Naoki, Katsuhiko; Taniguchi, Marie; Matsumoto, Naoya; Ohdo, Shigehiro

doi:10.1016/j.dmpk.2016.10.346

Drug Metabolism and Pharmacokinetics

2017

DOI: 10.1016/j.dmpk.2016.10.346

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Circadian oscillation in the intestinal expression of OCTN1/SLC22A4 underlies the dosing time-dependent changes in the absorption of pregabalin and its analgesic effects on diabetic neuropathy

Satoru Koyanagi

Takuya Akamine

Erika Wada

et al.

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Circadian oscillation in the intestinal expression of OCTN1/SLC22A4 underlies the dosing time-dependent changes in the absorption of pregabalin and its analgesic effects on diabetic neuropathy

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