Circadian organization of thirteen liver and six brain enzymes of the mouse

North, Chester; Feuers, Ritchie J.; Scheving, Lawrence E.; Pauly, John E.; Tsai, T H; Casciano, Daniel A.

doi:10.1002/aja.1001620302

Cited by 55 publications

(18 citation statements)

References 20 publications

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“…Particularly, LDH 1 is in myocardium, in red blood cells, in kidney (at cortical level) and in skeletal muscles; LDH 2 is in myocardium, in red blood cells, in kidney (at cortical level), in pancreas, in lung and in skeletal muscle LDH 3 is in lung, placenta, in skeletal muscle and in pancreas; LDH 4 in kidney (at medulla level), in skeletal muscles, in lung and in placenta; LDH 5 is in liver, kidney (at medulla level), skeletal muscle and in pancreas (Wolf and Williams, 1973). In previous studies (North et al, 1981;Zaleska-Freljian and Priebe, 1991) LDH showed rhythmicity with acrophases prior to the dark onset that seemed to be influenced by feeding (Sitren and Stevenson, 1978). In our study, liver LDH showed a rhythmic pattern coincident with values reported in literature (Figures 2A and B).…”

Section: Discussionsupporting

confidence: 91%

Daily Rhythm of Lactate Dehydrogenase in Rat (Rattus norvegicus) Carrying a Per1-luciferase Transgene: Assessment on Serum and Liver

et al. 2005

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Section: Discussionsupporting

confidence: 91%

Daily Rhythm of Lactate Dehydrogenase in Rat (Rattus norvegicus) Carrying a Per1-luciferase Transgene: Assessment on Serum and Liver

et al. 2005

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“…Most enzymes from young mice had acrophases which were within the last half of the light and the first half of the dark span. This result was similar to other work where acrophases tended to be at the time of transi tion from light to dark [North et al, 1981]. The acrophases of enzymes from old mice were similar to those of young mice, except in the case of LDH, and no new pattern con cerning response to the SLD schedule was observed.…”

Section: Resultssupporting

confidence: 79%

“…The SLD system may have been a confounding factor. In a previous study [North et al, 1981], where young mice were standardized for 2 weeks to a single light-dark schedule (LD), the rhythms observed in these enzymes were de scribed well by a cosine function. In the cur rent study, most of these enzymes did not fit the cosine function.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Age on the Orcadian Rhythms of 23 Liver or Brain Enzymes from C57BL/6J Mice

Feuers¹,

Delongchamp²,

Kramer³

et al. 1985

Gerontology

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Mice were standardized to 12 h of light exposure alternating with 12 h of darkness and were fed ad libitum. The mice in the first group were 8 weeks old and in the other 104–116 weeks old. Subgroups of 7 animals from each age group were killed at 6 circadian stages. Enzyme activities of 23 enzymes from liver or brain were measured by an analysis of variance for each age group. All but 1 enzyme from young mice, and all but 9 from older mice showed significant changes over time (p < 0.01). The data from the 22 enzymes from young mice and the 14 enzymes from old mice were fit to the cosinor regression model to further characterize the rhythm. 15 enzymes from the young and 8 from the aged mice showed a significant regression to a 24-hour cosine curve (p < 0.01); of the 8, 7 were the same enzymes in both groups. Amplitude changes, where they could be compared from the cosinor data (7 enzymes), were not statistically different. When total variance was compared, 12 enzymes showed unequal variance. Of these, old mice had the larger variance in 9 enzymes. Another difference between the young and the old was changes in mean enzyme activities. 12 enzymes from aged mice had decreased mesors, 2 had increased mesors, and 9 were unchanged. In general, our data suggest that some enzyme activity rhythms were lost, others were altered and a few were not affected by aging. In the case of many enzymes, older mice have a diminished ability to synchronize to the light signals.

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“…18) Because there are significant circadian rhythms in enzyme activity, 19,20) renal function, 21,22) blood flow, 23) and protein binding, 24) the pharmacokinetics and pharmacodynamics of many drugs are affected by circadian variations. 25,26) DPD, a major catabolic enzyme of 5-FU, has been reported to exhibit a circadian rhythm, and the variations have been correlated with the efficacy and toxicity of 5-FU in experimental animals 6,7) and cancer patients.…”

Section: Discussionmentioning

confidence: 99%

CPT‐11 Alters the Circadian Rhythm of Dihydropyrimidine Dehydrogenase mRNA in Mouse Liver

Shimizu

Tamura

Yamada

et al. 2001

Japanese Journal of Cancer Research

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Combination chemotherapy consisting of 5-fluorouracil (5-FU) and 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carboxycamptothecin (CPT-11) is a promising regimen for gastrointestinal cancer. The circadian-dependent efficacy and toxicity of 5-FU are related to the circadian variation in the activity of dihydropyrimidine dehydrogenase (DPD), which is a rate-limiting enzyme in the pyrimidine catabolic pathway. To optimize the schedule of the CPT-11 plus 5-FU combination, we investigated the effect of CPT-11 on the circadian rhythm of DPD in vivo. In control mice, the DPD mRNA level in the liver was significantly higher at 14:00 than that at 02:00. After intravenous administration of CPT-11 (30 mg/kg) at 20:00, the circadian rhythm of the DPD mRNA level in the liver was no longer observed 18 h later (14:00), but it was unaffected 6 and 18 h later (at 14:00 and 02:00) when CPT-11 was given at 08:00. In addition, a dose-dependent lengthening of the period of the circadian rhythm of DPD was observed for 42 h after intravenous injection of CPT-11 at 20:00. The levels of DPD protein and activity at 21 h after administration of CPT-11 (at 17:00) were significantly higher than at 9 h (at 05:00). These results suggest that CPT-11 may influence the circadian rhythm of DPD at the transcriptional level. Modulation of the circadian rhythm of DPD by CPT-11 may be a factor in optimizing the combination of 5-FU and CPT-11.Key words: CPT-11 -Dihydropyrimidine dehydrogenase -Circadian rhythm 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carboxycamptothecin (CPT-11) is one of the most potent therapeutic agents for the treatment of solid tumors, including lung, colorectal, and cervical cancer, and malignant lymphoma, 1,2) and combination regimens of CPT-11 and 5-fluorouracil (5-FU) have recently been evaluated in metastatic colorectal cancer patients.3, 4) Combination chemotherapy consisting of CPT-11, 5-FU, and leucovorin has been reported to be well tolerated and to have greater efficacy than 5-FU alone for first-line metastatic colorectal cancer. 5)Dihydropyrimidine dehydrogenase (DPD) is the ratelimiting enzyme in 5-FU catabolism, and it has been found to exhibit circadian variation in experimental animals 6,7) and cancer patients. 8) A study in cancer patients treated with 5-FU showed an inverse relationship between DPD activity in peripheral blood mononuclear cells and the plasma concentration of 8) and the circadian variation in 5-FU toxicity in rats has been reported to be inversely correlated with the circadian variation in DPD activity. 9)The relevance of chronotherapy using 5-FU, folinic acid, and oxaliplatin was investigated in phase II trials in metastatic colorectal cancer patients. 10)The mechanisms regulating circadian rhythms in a variety of species have recently been clarified. In mammals, the suprachiasmatic nucleus (SCN) of the anterior hypothalamus has been shown to be a circadian pacemaker, 11) and the human and mouse homologues of the mammalian period gene, which plays a central role in circadian rhythms, have been iso...

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Circadian organization of thirteen liver and six brain enzymes of the mouse

Cited by 55 publications

References 20 publications

Daily Rhythm of Lactate Dehydrogenase in Rat (Rattus norvegicus) Carrying a Per1-luciferase Transgene: Assessment on Serum and Liver

Daily Rhythm of Lactate Dehydrogenase in Rat (Rattus norvegicus) Carrying a Per1-luciferase Transgene: Assessment on Serum and Liver

The Effect of Age on the Orcadian Rhythms of 23 Liver or Brain Enzymes from C57BL/6J Mice

CPT‐11 Alters the Circadian Rhythm of Dihydropyrimidine Dehydrogenase mRNA in Mouse Liver

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