Circadian misalignment is associated with Covid-19 infection

Coelho, Julien; Micoulaud‐Franchi, Jean‐Arthur; Wiet, Anne-Sophie; Nguyen, Duc Trung; Taillard, Jacques; Philip, Pierre

doi:10.1016/j.sleep.2022.03.015

Cited by 9 publications

(9 citation statements)

References 22 publications

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“…Sleep and circadian rhythms play an important role in immunological functions [ 10 ]. A recent study identified that circadian misalignment, also known as social jet lag, is associated with COVID-19 [ 21 ]. Henríquez-Beltrán et al also reported circadian disruption, including significant fragmentation of the rest–activity rhythm, four months after COVID-19 [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Sleep and Circadian Rhythm in Relation to COVID-19 and COVID-19 Vaccination—National Sleep Survey of South Korea 2022

Han

Lee

Cho

et al. 2023

JCM

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Background: Currently, information on sleep and circadian patterns in relation to COVID-19 or vaccination remains limited. We aimed to investigate sleep and circadian patterns according to history of COVID-19 and COVID-19 vaccination side effects. Methods: We used data from the National Sleep Survey of South Korea 2022, a nationwide cross-sectional population-based survey regarding sleep–wake behaviors and sleep problems among Korean adults. Analysis of covariance (ANCOVA) and logistic regression analyses were performed to explore the different sleep and circadian patterns according to the history of COVID-19 or self-reported side effects of the COVID-19 vaccination. Results: The ANCOVA showed that individuals with a history of COVID-19 presented a later chronotype than individuals without a history of COVID-19. Individuals who had experienced vaccine-related side effects had a shorter sleep duration, poorer sleep efficiency, and worse insomnia severity. Multivariable logistic regression analysis showed a later chronotype related to COVID-19. A short sleep duration, poorer sleep efficiency, and worse insomnia severity were associated with self-reported side effects of the COVID-19 vaccination. Conclusions: Individuals who recovered from COVID-19 had a later chronotype than those without a history of COVID-19. Individuals who had experienced vaccine-related side effects presented with poorer sleep than those without side effects.

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Section: Discussionmentioning

confidence: 99%

Sleep and Circadian Rhythm in Relation to COVID-19 and COVID-19 Vaccination—National Sleep Survey of South Korea 2022

Han

Lee

Cho

et al. 2023

JCM

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“…Many lifestyle and environmental factors are implicated in the instigation and progression of cardiovascular disease, such as exposure to toxic agents (e.g., inhaled air pollution), medication side effects, and negative maintenance of health through poor diet, sedentary lifestyle, and inadequate sleep. Poor sleep is a burgeoning global public health problem exacerbated by psychosocial stress associated with socioeconomic disadvantage ( 2 , 3 ), climate change ( 4 ), the increased prevalence of wildfires ( 5 , 6 ), and incompletely understood emerging threats such as the COVID-19 pandemic ( 7 ), among other factors. Perturbations in sleep patterns, including insomnia or disrupted sleep, alter cardiovascular function and increase risk of atherosclerosis, stroke, and hypertension ( 8 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

“…health problem exacerbated by psychosocial stress associated with socioeconomic disadvantage (2,3), climate change (4), the increased prevalence of wildfires (5,6), and incompletely understood emerging threats such as the COVID-19 pandemic (7), among other factors. Perturbations in sleep patterns, including insomnia or disrupted sleep, alter cardiovascular function and increase risk of atherosclerosis, stroke, and hypertension (8)(9)(10).…”

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confidence: 99%

Wildfire-related smoke inhalation worsens cardiovascular risk in sleep disrupted rats

Martin

Schladweiler

Oshiro

et al. 2023

Front. Environ. Health

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IntroductionAs a lifestyle factor, poor sleep status is associated with increased cardiovascular morbidity and mortality and may be influenced by environmental stressors, including air pollution.MethodsTo determine whether exposure to air pollution modified cardiovascular effects of sleep disruption, we evaluated the effects of single or repeated (twice/wk for 4 wks) inhalation exposure to eucalyptus wood smoke (ES; 964 µg/m3 for 1 h), a key wildland fire air pollution source, on mild sleep loss in the form of gentle handling in rats. Blood pressure (BP) radiotelemetry and echocardiography were evaluated along with assessments of lung and systemic inflammation, cardiac and hypothalamic gene expression, and heart rate variability (HRV), a measure of cardiac autonomic tone.Results and DiscussionGH alone disrupted sleep, as evidenced by active period-like locomotor activity, and increases in BP, heart rate (HR), and hypothalamic expression of the circadian gene Per2. A single bout of sleep disruption and ES, but neither alone, increased HR and BP as rats transitioned into their active period, a period aligned with a critical early morning window for stroke risk in humans. These responses were immediately preceded by reduced HRV, indicating increased cardiac sympathetic tone. In addition, only sleep disrupted rats exposed to ES had increased HR and BP during the final sleep disruption period. These rats also had increased cardiac output and cardiac expression of genes related to adrenergic function, and regulation of vasoconstriction and systemic blood pressure one day after final ES exposure. There was little evidence of lung or systemic inflammation, except for increases in serum LDL cholesterol and alanine aminotransferase. These results suggest that inhaled air pollution increases sleep perturbation-related cardiovascular risk, potentially in part by increased sympathetic activity.

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“…In modern life, people may be exposed daily to different sources of stress, such as constant digital connection, heavy workload, changes in sleep wake schedules, or fear of climate change. It has been shown that chronic stress is associated with an increase in the global prevalence of mental and physical health problems, such as anxiety and depression [5][6][7], but also cardiovascular diseases [8,9]. In addition, it is now known that the COVID-19 pandemic-related stress has affected the brain and mental health.…”

Section: Introductionmentioning

confidence: 99%

Acute Effect of a Saffron Extract (Safr’InsideTM) and Its Main Volatile Compound on the Stress Response in Healthy Young Men: A Randomized, Double Blind, Placebo-Controlled, Crossover Study

et al. 2023

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According to animal studies, saffron and its main volatile compound safranal may reduce biological and behavioral signs of acute stress. However, little is known about its impact in humans. This study investigated the acute effect of a saffron extract and safranal on the biological and psychological stress responses in healthy men experiencing a laboratory stress procedure. In this double-blind, placebo-controlled, randomized, cross-over study, 19 volunteers aged 18–25 received a single dose of 30 mg saffron extract (Safr’InsideTM), 0.06 mg synthetic safranal, or a placebo on three visits separated by a 28-day washout. Thirteen minutes after administration, participants were exposed to the Maastricht acute stress test (MAST). Salivary cortisol and cortisone were collected from 15 min before the MAST (and pre-dose), 3 min before the MAST, and then 15, 30, 45, 60, and 75 min after the MAST, and stress and anxiety were measured using visual analogic scales. Compared to the placebo, stress and anxiety were significantly toned down after Safranal and Safr’InsideTM administration and coupled with a delay in the times to peak salivary cortisol and cortisone concentrations (p < 0.05). Safr’InsideTM and its volatile compound seem to improve psychological stress response in healthy men after exposure to a lab-based stressor and may modulate the biological stress response.

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Circadian misalignment is associated with Covid-19 infection

Cited by 9 publications

References 22 publications

Sleep and Circadian Rhythm in Relation to COVID-19 and COVID-19 Vaccination—National Sleep Survey of South Korea 2022

Sleep and Circadian Rhythm in Relation to COVID-19 and COVID-19 Vaccination—National Sleep Survey of South Korea 2022

Wildfire-related smoke inhalation worsens cardiovascular risk in sleep disrupted rats

Acute Effect of a Saffron Extract (Safr’InsideTM) and Its Main Volatile Compound on the Stress Response in Healthy Young Men: A Randomized, Double Blind, Placebo-Controlled, Crossover Study

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