Circadian miR-218-5p targets gene CA2 to regulate uterine carbonic anhydrase activity during egg shell calcification

Du, Xiaxia; Cui, Zhifu; Ning, Zifan; Deng, Xinyang; Amevor, Felix Kwame; Shu, Gang; Wang, Xiaoqi; Zhang, Zhichao; Tian, Yaofu; Zhu, Qing; Wang, Yan; Li, Diyan; Zhang, Yao; Zhao, Xiaoling

doi:10.1016/j.psj.2022.102158

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Among all differential proteins, the protein that was down-regulated by Model/Control and up-regulated by WPH-H/Model was CA2; the protein that was up-regulated by Model/Control and down-regulated by WPH-H/Model was ITIH4. CA2 is carbonic anhydrase 2, a member of the carbonic anhydrase (CA) family, which is involved in various processes such as intra-and extracellular pH homeostasis and vascular regulation [41]. The down-regulation of CA2 protein in the colonic mucosa of UC patients causes an imbalance of colonic luminal pH and disruption of the mucosal epithelial barrier, which leads to uncontrolled inflammation in UC [42].…”

Section: Functional Annotation and Enrichment Analysis Of Colonic Dif...mentioning

confidence: 99%

Whey Protein Hydrolysate Exerts Anti-Inflammatory Effects to Alleviate Dextran Sodium Sulfate (DSS)-Induced Colitis via Microbiome Restoration

Zou,

Fu,

Guo

et al. 2023

Nutrients

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Whey protein hydrolysate (WPH) has been shown to have a variety of bioactivities. This study aimed to investigate the preventive effect of WPH on dextran sodium sulfate (DSS)-induced colitis in C57BL/6J mice. The results indicated that WPH intervention for 37 days was effective in delaying the development of colonic inflammation, and high doses of WPH significantly inhibited weight loss (9.16%, n = 8, p < 0.05), protected the colonic mucosal layer, and significantly reduced the levels of inflammatory factors TNF-α, IL-6, and IL-1β in mice with colitis (n = 8, p < 0.05). In addition, WPH intervention was able to up-regulate the short-chain fatty acids secretion and restore the gut microbiome imbalance in mice with colitis. Notably, high-dose WPH intervention increased the relative abundance of norank_f_Muribaculaceae by 1.52-fold and decreased the relative abundance of Romboutsia and Enterobacter by 3.77-fold and 2.45-fold, respectively, compared with the Model group. WPH intervention protected colitis mice mainly by reversing the microbiome imbalance and regulating the major histocompatibility complex (MHC) class I pathway. This study showed that WPH has anti-inflammatory activity and a promising colitis management future.

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Section: Functional Annotation and Enrichment Analysis Of Colonic Dif...mentioning

confidence: 99%

Whey Protein Hydrolysate Exerts Anti-Inflammatory Effects to Alleviate Dextran Sodium Sulfate (DSS)-Induced Colitis via Microbiome Restoration

Zou,

Fu,

Guo

et al. 2023

Nutrients

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show abstract

“…Du et al found that Circadian miR-449c-5p regulates uterine Ca2+ transport during eggshell calcification. Circadian miR-218-5p regulates uterine carbonic anhydrase activity during eggshell calcification through its target gene CA2 ( Du X et al, 2022 ). By sequencing the eggshell glands of ducks, Xu et al found that gga-miR-144-3p regulates the ABC transporter pathway by upregulating ABCG2 expression ( Xu et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Whole transcriptome sequencing reveals key genes and ceRNA regulatory networks associated with pimpled eggs in hens

Li,

Cao,

et al. 2024

Poultry Science

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Genome-wide re-sequencing reveals selection signatures for important economic traits in Taihang chickens

Zhang,

Wang,

Zhang

et al. 2024

Poultry Science

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Circadian miR-218-5p targets gene CA2 to regulate uterine carbonic anhydrase activity during egg shell calcification

Cited by 4 publications

References 44 publications

Whey Protein Hydrolysate Exerts Anti-Inflammatory Effects to Alleviate Dextran Sodium Sulfate (DSS)-Induced Colitis via Microbiome Restoration

Whey Protein Hydrolysate Exerts Anti-Inflammatory Effects to Alleviate Dextran Sodium Sulfate (DSS)-Induced Colitis via Microbiome Restoration

Whole transcriptome sequencing reveals key genes and ceRNA regulatory networks associated with pimpled eggs in hens

Genome-wide re-sequencing reveals selection signatures for important economic traits in Taihang chickens

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