“…This subset of ganglion cells are part of the non-image-forming mechanism of the eye because of their projection to regions of the suprachiasmatic nucleus (SCN) and olivary pretectal nucleus (OPN) (Ruby et al, 2002;Berson, 2003;Hattar et al, 2003;Do et al, 2009;Ecker et al, 2010;Allen et al, 2019;Do, 2019). As a result, the ipRGCs can modulate the circadian rhythm (Freedman, 1999;Brainard et al, 2001;Thapan et al, 2001;Rea and Figueiro, 2018;Truong et al, 2020) and pupil light response (Lucas et al, 2001(Lucas et al, , 2020Gamlin et al, 2007;Young and Kimura, 2008;Barrionuevo et al, 2018;Murray et al, 2018) via a processing path that works independently of the classical image-forming pathway (Hattar et al, 2006;Güler et al, 2008;Schmidt et al, 2014;Spitschan, 2019a). Recent studies showed that the pupil light response cannot be described by the V(λ) weighted luminance alone, making a revision of classical pupil models necessary (Zandi et al, 2018(Zandi et al, , 2020Spitschan, 2019b;Zele et al, 2019).…”