Circadian locomotor activity and response to different light conditions in the Volcano mouse,<i>Neotomodon alstoni</i>(Merriam, 1898)

Fuentes-Granados, Citlalli; Miranda‐Anaya, Manuel; Samario-Román, Jazmín; Moreno‐Sáenz, Enrique; Carmona-Castro, Agustín; Cárdenas-Vázquez, René

doi:10.1080/09291010902863420

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…SWS increased in obese mice, both in the photophase and scotophase, whereas no differences in REMS were observed. The distribution of activity during the course of the LD cycle indicates that these animals present frequent arousals and quiet waking periods, a behavioral pattern which is sometimes observed in non-wheel running environments (Fuentes-Granados et al 2010) and is also consistent with previous studies of sleep in this species (Ayala-Guerrero et al 1998). The difference in W evaluated by ECoG, is however not detected when activity is tested by infrared crossings (data not shown).…”

supporting

confidence: 89%

“…However, the volcano mouse, Neotomodon alstoni, is an endemic species from the trans-volcano belt of Mexico. This species has been the subject of diverse biological and physiological studies including circadian rhythms (Fuentes-Granados et al 2010) and the sleep-wake cycle (Ayala-Guerrero et al 1998). Young animals captured in the field and kept under vivarium conditions, show body weight increases when fed a regular rodent chow, around 50% of them developing obesity.…”

Section: Introductionmentioning

confidence: 99%

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Obesity alters the daily sleep homeostasis and metabolism of the volcano mouseNeotomodon alstoni

Fuentes-Granados¹,

Durán

Carmona-Castro³

et al. 2012

Biological Rhythm Research

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Some Mexican volcano mice (Neotomodon alstoni), when in captivity and fed regularly on a laboratory rodents' diet, develop obesity. The aims of the present work are to compare lean and obese mice with regard to the main characteristics of the sleep-wake cycle in 12:12 LD, and to investigate if there is a correlation with changes in metabolic-related blood parameters (leptin, insulin, triacylglycerides, corticosterone and the glucose tolerance test). The analysis of the sleep-wake cycle evaluated the temporal distribution of vigilance states and indicated a polyphasic architecture. Trends were observed in obese mice to have increased percentages of slow wave sleep and decreased wakefulness, but the percentage of rapid eye movement sleep was not different. Obese mice had higher concentrations of leptin and insulin, and showed a slower glucose removal from blood at noon than at midnight, indicating a possible resistance to these hormones. We propose that volcano mice are a good model for studying daily rhythms and metabolic disorders related to obesity.

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supporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Obesity alters the daily sleep homeostasis and metabolism of the volcano mouseNeotomodon alstoni

Fuentes-Granados¹,

Durán

Carmona-Castro³

et al. 2012

Biological Rhythm Research

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“…Obese mice present hyperleptinemia and some other metabolic and neural changes related to food intake [ 39 40 41 ]. Experiments in vitro of the rat’s SCN indicate that leptin changes the membrane potential and the spike shape, inducing phase advances in the firing rate [ 9 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Ghrelin is a possible food-related entraining signal that may induce phase advance in the SCN [ 12 ]. It is possible that differences in ghrelin signaling may be present in the obesity condition in Neotomodon [ 41 ]. This suggestion requires experimental testing involving daily comparisons of the levels of ghrelin and its receptor between obese and lean Neotomodon mice, to see if there is some relationship with the differences in phase shift induced by light.…”

Section: Discussionmentioning

confidence: 99%

“…It is particularly useful to understand whether the altered mechanisms in obesity occur regardless of the model used, or if they are a consequence of the specific method used to induce obesity [38]. The endemic Mexican volcano mouse, Neotomodon alstoni, is an advantageous model for a variety of behavioral and physiological studies, including circadian rhythms and its relation to obesity [394041] and hypothalamic integration of food intake [42]. In this context, a mouse such as N. alstoni offers a different perspective, since some of these mice develop obesity with standard rodent diets, while others remain lean.…”

Section: Introductionmentioning

confidence: 99%

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Differences in Photic Entrainment of Circadian Locomotor Activity Between Lean and Obese Volcano Mice (Neotomodon alstoni)

Miranda‐Anaya¹,

Luna-Moreno²,

Carmona-Castro³

et al. 2017

Journal of Circadian Rhythms

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Obesity is a growing problem worldwide with a clear impact on health status. It is also a condition that negatively affects circadian rhythms. When the mouse Neotomodon alstoni is fed a regular rodent chow, some individuals develop obesity, representing an opportunity to compare the effects of spontaneous obesity upon the circadian organization in this species with that observed in other rodents with induced obesity. We report differences in the free running circadian locomotor activity rhythm and in the effects of light pulses between lean and obese mice. Also, the photo-induced expression of the c-Fos protein and vasoactive intestinal peptide (VIP) in the suprachiasmatic nucleus (SCN) were examined at circadian time (CT) 14 and 22. We show that obese mice have a larger dispersion of the period of circadian locomotor rhythm in constant darkness. Photic induced phase shifts are nearly 50% shorter at CT 14, and 50% larger at CT 22 than in lean mice. The photoinduction of VIP in the SCN at CT 22 was larger in obese mice, which may be related to the differences observed in photic phase shifting. Our work indicates that the obesity in Neotomodon has effects on the neural mechanisms that regulate the circadian system.

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Unimodal daily distribution of activity in antelope ground squirrels under stable environmental conditions

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2020

Mamm Res

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Circadian locomotor activity and response to different light conditions in the Volcano mouse,Neotomodon alstoni(Merriam, 1898)

Cited by 10 publications

References 24 publications

Obesity alters the daily sleep homeostasis and metabolism of the volcano mouseNeotomodon alstoni

Obesity alters the daily sleep homeostasis and metabolism of the volcano mouseNeotomodon alstoni

Differences in Photic Entrainment of Circadian Locomotor Activity Between Lean and Obese Volcano Mice (Neotomodon alstoni)

Unimodal daily distribution of activity in antelope ground squirrels under stable environmental conditions

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