Circadian feeding entrains anticipatory metabolic activity in piriform cortex and olfactory tubercle, but not in suprachiasmatic nucleus

Olivo, Diana; Caba, Mario; González-Lima, Francisco; Espinoza-Vázquez, Araceli; Corona-Morales, Aleph A.

doi:10.1016/j.brainres.2014.09.054

Cited by 15 publications

(11 citation statements)

References 48 publications

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“…illustrated in Figs 2.4 to 6.2) as observed in adult rabbits: (i) the superficial plexiform layer, (ii) the superficial compact cell layer and (iii) the deep cell layer (Krakowska et al 2013). The PCx appears to be involved in perception of the MP and single conditioned odorants presented alone or in elemental/configural mixtures in 0-and 4-day-old pups (Charra et al 2012(Charra et al , 2013Schneider et al 2016a,b) and shows feeding-entrained anticipatory metabolic activity in 7day-old pups (Olivo et al 2014). Caudally, the pPCx meets with the entorhinal cortex (Ent) (Figs 7.1 to 8.2).…”

Section: The Main Olfactory Circuitmentioning

confidence: 87%

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Brain anatomy of the 4‐day‐old European rabbit

2018

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The European rabbit (Oryctolagus cuniculus) is a widely used model in fundamental, medical and veterinary neurosciences. Besides investigations in adults, rabbit pups are relevant to study perinatal neurodevelopment and early behaviour. To date, the rabbit is also the only species in which a pheromone - the mammary pheromone (MP) - emitted by lactating females and active on neonatal adaptation has been described. The MP is crucial since it contributes directly to nipple localisation and oral seizing in neonates, i.e. to their sucking success. It may also be one of the non-photic cues arising from the mother, which stimulates synchronisation of the circadian system during pre-visual developmental stages. Finally, the MP promotes neonatal odour associative and appetitive conditioning in a remarkably rapid and efficient way. For these different reasons, the rabbit offers a currently unique opportunity to determine pheromonal-induced brain processing supporting adaptation early in life. Therefore, it is of interest to create a reference work of the newborn rabbit pup brain, which may constitute a tool for future multi-disciplinary and multi-approach research in this model, and allow comparisons related to the neuroethological basis of social and feeding behaviour among newborns of various species. Here, in line with existing experimental studies, and based on original observations, we propose a functional anatomical description of brain sections in 4-day-old rabbits with a particular focus on seven brain regions which appear important for neonatal perception of sensory signals emitted by the mother, circadian adaptation to the short and single daily nursing of the mother in the nest, and expression of specific motor actions involved in nipple localisation and milk intake. These brain regions involve olfactory circuits, limbic-related areas important in reward, motivation, learning and memory formation, homeostatic areas engaged in food anticipation, and regions implicated in circadian rhythm and arousal, as well as in motricity.

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Section: The Main Olfactory Circuitmentioning

confidence: 87%

“…,b) and shows feeding‐entrained anticipatory metabolic activity in 7‐day‐old pups (Olivo et al. ). Caudally, the pPCx meets with the entorhinal cortex (Ent) (Figs 7.1 to 8.2).…”

Section: Methodsmentioning

confidence: 99%

Brain anatomy of the 4‐day‐old European rabbit

2018

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“…In the anterior pyriform cortex, olfactory tubercle, and olfactory bulb CO activity increased in anticipation of and after nursing, at both feeding schedules. By contrast, in the SCN the temporal pattern of CO staining was not modified by nursing time (Olivo, Caba, González‐Lima, Vázquez, & Corona‐Morales, ).…”

Section: Behavioral Neuroendocrinologymentioning

confidence: 99%

Behavioral, neuroendocrine and physiological indicators of the circadian biology of male and female rabbits

Aguilar‐Roblero

González‐Mariscal

2018

Eur J of Neuroscience

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Adult rabbits show robust circadian rhythms of: nursing, food and water intake, hard faeces excretion, locomotion, body temperature, blood and intraocular pressure, corticosteroid secretion, and sleep. Control of several circadian rhythms involves a light‐entrained circadian clock and a food‐entrained oscillator. Nursing periodicity, however, relies on a suckling stimulation threshold. Brain structures regulating this activity include the paraventricular nucleus and preoptic area, as determined by lesions and quantification of cFOS‐ and PER1 clock gene‐immunoreactive proteins. Melatonin synthesis in the rabbit pineal gland shows a diurnal rhythm, with highest values at night and lowest ones during the day. In kits the main zeitgeber is milk intake, which synchronizes locomotor activity, body temperature, and corticosterone secretion. Brain regions involved in these effects include the median preoptic nucleus and several olfactory structures. As models for particular human illnesses rabbits have been valuable for studying glaucoma and cardiovascular disease. Circadian variations in intraocular pressure (main risk factor for glaucoma) have been found, with highest values at night, which depend on sympathetic innervation. Rabbits fed a high fat diet develop cholesterol plaques and high blood pressure, as do humans, and such increased fat intake directly modulates cardiovascular homeostasis and circadian patterns, independently of white adipose tissue accumulation. Rabbits have also been useful to investigate the characteristics of sleep across the day and its modulation by infections, cytokines and other endogenous humoral factors. Rabbit circadian biology warrants deeper investigation of the role of the suprachiasmatic nucleus in regulating most behavioral and physiological rhythms described above.

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“…Some studies showed that changes in behavior and physiological functions, such as locomotor activity, body temperature, blood hormones occurred before the anticipatory timed nutrients, were established by restricted daily feeding schedules (18). Olivo D et al found that the anticipatory metabolic activity entrained by feeding schedules exsisted in piriform cortex and olfactory tubercle, but not in suprachiasmatic nucleus (19). Timed nutrients shifted the circadian phases of clock genes at the mRNA and protein levels in the gastrointestinal tract but not in the central SCN clock (20).…”

Section: Timed Nutrients and Circadian Rhythmsmentioning

confidence: 99%

Nutrients and Circadian Rhythms in Mammals

Yao

Huang

et al. 2015

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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In mammals, the approximate 24-h rhythm in behavior and physiology is generally existed, such as wake/ sleep cycle, blood pressure, body temperature and concentration of melatonin. The circadian rhythms result from the cell-autonomous and self-sustained oscillators (circadian clocks), which rely on interlocking transcription/translational feedback loops involving a series of clock genes (Clock, Bmal1, Per, Cry, Dec etc.) and their proteins (1). The mammalian circadian clocks are composed of a master clock located in the hypothalamic suprachiasmatic nucleus (SCN), and of many peripheral clocks in tissues and extra-SCN brain regions (2). The master clock is mainly entrained by the light cue, while the peripheral clocks are not only affected by the SCN clock but also entrained by the food cue (3). Moreover, feeding could take over part of the SCN signaling, and affect internal synchrony between the master clock and the peripheral clocks. Nutrient Components and Circadian RhythmsNutrient components have been identified as important factors to entrain the peripheral circadian clocks (4).Glucose is a particularly potent entraining factor for peripheral clocks (5). Min-Dian Li et al. found that high concentration of glucose increased the transcription levels of Bmal1 and Cry1 genes without the alteration of the phase of Bmal1 cycling, and low concentration of glucose delayed the phase of BMAL1 protein accumulation via western blot (6). How could glucose influence the circadian clock and further affect the following metabolic process aroused extensive attention. Some researchers revealed that cellular nutrient sensors such as nuclear receptors were proposed as candidates for the circadian clock entrainment by nutrient components (7,8). A recent study showed that the O-GlcNAc signaling entrained the circadian clock by inhibiting BMAL1/ CLOCK ubiquitination, which may be the molecular mechanism underlying the glucose entrainment of the circadian clock (6).Intraperitoneal injection of amino acids combined with glucose delayed the phase of the liver clock as similar as the effect of delayed feeding (9). l-carnosine is a dipeptide of the amino acids b-alanine and l-histidine, which is identified to be related with various physiological alterations (including blood glucose, blood pressure etc.) through the autonomic nerves. Bilateral lesions of the SCN in rat results in destructive effects on the carnosine induced physiological alterations mentioned above (10). In our study, we found that l-carnosine administration could accelerate the resetting rate of peripheral clock genes in the hearts, which is regulated by the autonomic nervous system (11).Alcohol is another entraining factor for circadian clocks. Chronic alcohol administration induced the hepatic steatosis and disturbed the circadian clocks in the liver (12). Studies in human indicated that the expression level of clock genes in leukocytes of male alcoholic patients were lower than the healthy men (13). Timed Nutrients and Circadian RhythmsTimed nutrients are as impor...

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Circadian feeding entrains anticipatory metabolic activity in piriform cortex and olfactory tubercle, but not in suprachiasmatic nucleus

Cited by 15 publications

References 48 publications

Brain anatomy of the 4‐day‐old European rabbit

Brain anatomy of the 4‐day‐old European rabbit

Behavioral, neuroendocrine and physiological indicators of the circadian biology of male and female rabbits

Nutrients and Circadian Rhythms in Mammals

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