Circadian Expression of the Steroid 15 α-Hydroxylase (<i>Cyp2a4</i>) and Coumarin 7-Hydroxylase (<i>Cyp2a5</i>) Genes in Mouse Liver Is Regulated by the PAR Leucine Zipper Transcription Factor DBP

Lavery, Daniel; Lopez‐Molina, Luis; Margueron, Raphaël; Fleury-Olela, Fabienne; Conquet, François; Schibler, Ueli; Bonfils, Claude

doi:10.1128/mcb.19.10.6488

Cited by 157 publications

(108 citation statements)

References 36 publications

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“…Finally, Dbp, a clock-controlled transcription factor, also showed a strong circadian oscillation. Dbp is thought to generate upstream signals for physiological processes under circadian regulation (39), as it has been proven for locomotor activity (40) and the expression of some liver enzymes (41). Moreover, the circadian rhythm of Dbp transcript levels matches with Per1 rhythm, as seen in other peripheral tissues (42,43).…”

Section: Discussionmentioning

confidence: 99%

Circadian Oscillations of Clock Genes, Cytolytic Factors, and Cytokines in Rat NK Cells

Arjona

Sarkar

2005

The Journal of Immunology

186

141

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A growing body of knowledge is revealing the critical role of circadian physiology in the development of specific pathological entities such as cancer. NK cell function participates in the immune response against infection and malignancy. We have reported previously the existence of a physiological circadian rhythm of NK cell cytolytic activity in rats, suggesting the existence of circadian mechanisms subjacent to NK cell function. At the cellular level, circadian rhythms are originated by the sustained transcriptional-translational oscillation of clock genes that form the cellular clock apparatus. Our aim in this study was to investigate the presence of molecular clock mechanisms in NK cells as well as the circadian expression of critical factors involved in NK cell function. For that purpose, we measured the circadian changes in the expression of clock genes (Per1, Per2, Bmal1, Clock), Dbp (a clock-controlled output gene), CREB (involved in clock signaling), cytolytic factors (granzyme B and perforin), and cytokines (IFN-γ and TNF-α) in NK cells enriched from the rat spleen. The results obtained from this study demonstrate for the first time the existence of functional molecular clock mechanisms in NK cells. Moreover, the circadian expression of cytolytic factors and cytokines in NK cells reported in this study emphasizes the circadian nature of NK cell function.

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Section: Discussionmentioning

confidence: 99%

Circadian Oscillations of Clock Genes, Cytolytic Factors, and Cytokines in Rat NK Cells

Arjona

Sarkar

2005

The Journal of Immunology

186

141

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“…Importantly, DBP binds to other gene promoters to temporally regulate their transcription. This process is important in the control of hepatic metabolic processes; DBP activates the transcription of albumin, cholesterol 7α hydroxylase, and cytochrome P450 (Lavery et al, 1999). This second order system can provide ubiquitous control via the circadian system and temporal control of key enzymatic pathways involved in hormone production.…”

Section: Indirect Transcriptional Controlmentioning

confidence: 99%

The regulation of neuroendocrine function: Timing is everything

Kriegsfeld

Silver

2006

Hormones and Behavior

129

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Hormone secretion is highly organized temporally, achieving optimal biological functioning and health. The master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus coordinates the timing of circadian rhythms, including daily control of hormone secretion. In the brain, the SCN drives hormone secretion. In some instances, SCN neurons make direct synaptic connections with neurosecretory neurons. In other instances, SCN signals set the phase of "clock genes" that regulate circadian function at the cellular level within neurosecretory cells. The protein products of these clock genes can also exert direct transcriptional control over neuroendocrine releasing factors. Clock genes and proteins are also expressed in peripheral endocrine organs providing additional modes of temporal control. Finally, the SCN signals endocrine glands via the autonomic nervous system, allowing for rapid regulation via multisynaptic pathways. Thus, the circadian system achieves temporal regulation of endocrine function by a combination of genetic, cellular, and neural regulatory mechanisms to ensure that each response occurs in its correct temporal niche. The availability of tools to assess the phase of molecular/cellular clocks and of powerful tract tracing methods to assess connections between "clock cells" and their targets provides an opportunity to examine circadian-controlled aspects of neurosecretion, in the search for general principles by which the endocrine system is organized. KeywordsCircadian; Diurnal; Endocrinel; Neurosecretion; Clock genes; Suprachiasmatic Circadian aspects of reproductionThe importance of circadian (about a day) timing in hormone production/secretion has been known since the 1950s when Everett and Sawyer determined that a stimulatory signal occurring during a narrow temporal window on the afternoon of proestrus is necessary for induction of ovulation later that night (Everett and Sawyer, 1950). Such close temporal organization is important for successful reproduction, as numerous hormone-dependent behavioral and physiological processes must be coordinated. If optimal temporal relationships are disrupted, pronounced deficits in fertility can result. For example, ovulation, behavioral estrus, fertilization, and pregnancy maintenance require a specific

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“…The subtle behavioral phenotype of dbp mutant mice did not reveal if this gene functions in the central pacemaking mechanisms or only in the clock output (Lopez-Molina et al, 1997; Table 3). Circadian expression of clock-output genes in the liver is directly regulated by DBP and severely blunted in dbp mutant mice, demonstrating a prominent role for DBP in regulating output genes (Lavery et al, 1999;Fig. 2).…”

Section: Genes Dbp (Albumin D-element Binding Protein)mentioning

confidence: 99%

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

2002

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ABSTRACT:The fruit fly, Drosophila melanogaster, has been a grateful object for circadian rhythm researchers over several decades. Behavioral, genetic, and molecular studies helped to reveal the genetic bases of circadian time keeping and rhythmic behaviors. Contrary, mammalian rhythm research until recently was mainly restricted to descriptive and physiologic approaches. As in many other areas of research, the surprising similarity of basic biologic principles between the little fly and our own species, boosted the progress of unraveling the genetic foundation of mammalian clock mechanisms. Once more, not only the basic mechanisms, but also the molecules involved in establishing our circadian system are taken or adapted from the fly. This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks.

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Circadian Expression of the Steroid 15 α-Hydroxylase (Cyp2a4) and Coumarin 7-Hydroxylase (Cyp2a5) Genes in Mouse Liver Is Regulated by the PAR Leucine Zipper Transcription Factor DBP

Cited by 157 publications

References 36 publications

Circadian Oscillations of Clock Genes, Cytolytic Factors, and Cytokines in Rat NK Cells

Circadian Oscillations of Clock Genes, Cytolytic Factors, and Cytokines in Rat NK Cells

The regulation of neuroendocrine function: Timing is everything

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

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