Circadian disturbances by altering the light–dark cycle negatively affects hematopoietic function of bone marrow in mice
Honglian Yang,
Guojie Zhao,
Yue Lu
et al.
Abstract:Circadian rhythms in metabolically active tissues are crucial for maintaining physical health. Circadian disturbance (CD) can cause various health issues, such as metabolic abnormalities and immune and cognitive dysfunctions. However, studies on the role of CD in immune cell development and differentiation, as well as the rhythmic expression of the core clock genes and their altered expression under CD, remain unclear. Therefore, we exposed C57bl/6j mice to repeated reversed light–dark cycles for 90 days to re… Show more
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