Circadian disruption-induced metabolic syndrome in mice is ameliorated by oat β-glucan mediated by gut microbiota

Cheng, Wai-Yin; Lam, Kwok Wai; Li, Xiaojie; Kong, Alice Pik‐Shan; Cheung, Peter C.K.

doi:10.1016/j.carbpol.2021.118216

Cited by 35 publications

(25 citation statements)

References 62 publications

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“…In agreement with the findings at phylum level, we found differential abundance of dominant classes, orders, families, genera in the fecal microbiota between PDC and non-PDC samples. At the family level, we noted that Ruminococcaceae (PDC vs non-PDC: P=0.002, PDC vs BC: P= 0.071), typically producing short chain fatty acids ( Cheng et al., 2021 ), depleted in the PDC group. Instead, Prevotellaceae was significantly enriched in the PDC group (PDC vs non-PDC: P= 0.002).…”

Section: Resultsmentioning

confidence: 96%

Obese Individuals With and Without Phlegm-Dampness Constitution Show Different Gut Microbial Composition Associated With Risk of Metabolic Disorders

Shin

Zhu

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundObesity is conventionally considered a risk factor for multiple metabolic diseases, such as dyslipidemia, type 2 diabetes, hypertension, and cardiovascular disease (CVD). However, not every obese patient will progress to metabolic disease. Phlegm-dampness constitution (PDC), one of the nine TCM constitutions, is considered a high-risk factor for obesity and its complications. Alterations in the gut microbiota have been shown to drive the development and progression of obesity and metabolic disease, however, key microbial changes in obese patients with PDC have a higher risk for metabolic disorders remain elusive.MethodsWe carried out fecal 16S rRNA gene sequencing in the present study, including 30 obese subjects with PDC (PDC), 30 individuals without PDC (non-PDC), and 30 healthy controls with balanced constitution (BC). Metagenomic functional prediction of bacterial taxa was achieved using PICRUSt.ResultsObese individuals with PDC had higher BMI, waist circumference, hip circumference, and altered composition of their gut microbiota compared to non-PDC obese individuals. At the phylum level, the gut microbiota was characterized by increased abundance of Bacteroidetes and decreased levels of Firmicutes and Firmicutes/Bacteroidetes ratio. At the genus level, Faecalibacterium, producing short-chain fatty acid, achieving anti-inflammatory effects and strengthening intestinal barrier functions, was depleted in the PDC group, instead, Prevotella was enriched. Most PDC-associated bacteria had a stronger correlation with clinical indicators of metabolic disorders rather than more severe obesity. The PICRUSt analysis demonstrated 70 significantly different microbiome community functions between the two groups, which were mainly involved in carbohydrate and amino acid metabolism, such as promoting Arachidonic acid metabolism, mineral absorption, and Lipopolysaccharide biosynthesis, reducing Arginine and proline metabolism, flavone and flavonol biosynthesis, Glycolysis/Gluconeogenesis, and primary bile acid biosynthesis. Furthermore, a disease classifier based on microbiota was constructed to accurately discriminate PDC individuals from all obese people.ConclusionOur study shows that obese individuals with PDC can be distinguished from non-PDC obese individuals based on gut microbial characteristics. The composition of the gut microbiome altered in obese with PDC may be responsible for their high risk of metabolic diseases.

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Section: Resultsmentioning

confidence: 96%

Obese Individuals With and Without Phlegm-Dampness Constitution Show Different Gut Microbial Composition Associated With Risk of Metabolic Disorders

Shin

Zhu

et al. 2022

Front. Cell. Infect. Microbiol.

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“…In addition, increased consumption of coarse cereals containing dietary fiber contributes to healthy functioning of the intestine. Oat β-glucan mitigated the inflammatory status in colon, enhanced colonic barrier function, and increased gut microbiota-derived SCFAs (butyrate) in vivo [46,47]. Tartary buckwheat-resistant starch improved intestinal health by regulating the gut microbiota composition and increasing the yield of SCFAs in HFD fed mice [48].…”

Section: Discussionmentioning

confidence: 98%

Effects of Oats, Tartary Buckwheat, and Foxtail Millet Supplementation on Lipid Metabolism, Oxido-Inflammatory Responses, Gut Microbiota, and Colonic SCFA Composition in High-Fat Diet Fed Rats

Wang

Guo

et al. 2022

Nutrients

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Coarse cereals rich in polyphenols, dietary fiber, and other functional components exert multiple health benefits. We investigated the effects of cooked oats, tartary buckwheat, and foxtail millet on lipid profile, oxido-inflammatory responses, gut microbiota, and colonic short-chain fatty acids composition in high-fat diet (HFD) fed rats. Rats were fed with a basal diet, HFD, oats diet (22% oat in HFD), tartary buckwheat diet (22% tartary buckwheat in HFD), and foxtail millet diet (22% foxtail millet in HFD) for 12 weeks. Results demonstrated that oats and tartary buckwheat attenuated oxidative stress and inflammatory responses in serum, and significantly increased the relative abundance of Lactobacillus and Romboutsia in colonic digesta. Spearman’s correlation analysis revealed that the changed bacteria were strongly correlated with oxidative stress and inflammation-related parameters. The concentration of the butyrate level was elevated by 2.16-fold after oats supplementation. In addition, oats and tartary buckwheat significantly downregulated the expression of sterol regulatory element-binding protein 2 and peroxisome proliferator-activated receptors γ in liver tissue. In summary, our results suggested that oats and tartary buckwheat could modulate gut microbiota composition, improve lipid metabolism, and decrease oxidative stress and inflammatory responses in HFD fed rats. The present work could provide scientific evidence for developing coarse cereals-based functional food for preventing hyperlipidemia.

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“…87 Emerging studies have demonstrated that dietary polysaccharides, such as β-glucan, inulin, and the Lycium barbarum polysaccharide (LBP), can change the phase and expression of clock genes and have a positive effect on circadian rhythms. 88–90 It was found that dietary intervention with a certain dose of β-glucan and inulin could regulate the expression and phase of circadian clock genes, making them closer to normal levels. These two polysaccharides clearly reversed the phase delay of Per1 and Per3 in the hypothalamus and restored the phase delay of Per2 in the liver of mice, and significantly reduced the abnormally high expression of Per2 induced by rhythm disturbance.…”

Section: Modulation Of Circadian Rhythms and Psychiatric Disorders By Plant Polysaccharidesmentioning

confidence: 99%

“…88 Notably, dietary interventions with β-glucan reduced the metabolic syndrome induced by circadian rhythm disturbances, reversed weight gain, and restored dextran tolerance. 89 In the study on the effect of LBP on type 2 diabetes mellitus (T2DM), the mechanism was found to be related to the expression of clock genes. A significant decrease in Clock and Bmal1 was observed in T2DM rats.…”

Section: Modulation Of Circadian Rhythms and Psychiatric Disorders By Plant Polysaccharidesmentioning

confidence: 99%

Strategies for circadian rhythm disturbances and related psychiatric disorders: a new cue based on plant polysaccharides and intestinal microbiota

Sun

Zhang

et al. 2022

Food Funct.

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Circadian disruption-induced metabolic syndrome in mice is ameliorated by oat β-glucan mediated by gut microbiota

Cited by 35 publications

References 62 publications

Obese Individuals With and Without Phlegm-Dampness Constitution Show Different Gut Microbial Composition Associated With Risk of Metabolic Disorders

Obese Individuals With and Without Phlegm-Dampness Constitution Show Different Gut Microbial Composition Associated With Risk of Metabolic Disorders

Effects of Oats, Tartary Buckwheat, and Foxtail Millet Supplementation on Lipid Metabolism, Oxido-Inflammatory Responses, Gut Microbiota, and Colonic SCFA Composition in High-Fat Diet Fed Rats

Strategies for circadian rhythm disturbances and related psychiatric disorders: a new cue based on plant polysaccharides and intestinal microbiota

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