Circadian developmental rhythms of the experimental paracetamol hepatitis and the effect of hepatoprotectors on the activity of pro-oxidative / antioxidant and cytolytic processes

Дроговоз, С. М.; Mishchenko, Oleg; Kalko, K. O.; Bogdan, N. S.; Gerush, Oleg

doi:10.24959/cphj.19.1485

Cited by 2 publications

(3 citation statements)

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“…Throughout the study, there was a progressive increase in TBA-AP content in both tissues, the maximum values of which were recorded on the 10th day of the experiment. Our experimental data are consistent with the results of studies by other authors, which showed that paracetamol poisoning activates the processes of free radical oxidation in animals [21,22].…”

Section: Discussion Of Research Resultssupporting

confidence: 93%

“…When comparing the indicators of lipoperoxidation with the indicators of oxidative modification of proteins, there was a tendency to increase them after the defeat of paracetamol. This confirms the relationship and interdependence of these processes in the development of pathological conditions, which is given in other experimental works [21,22].…”

Section: Discussion Of Research Resultssupporting

confidence: 91%

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The study of oxidative stress indicators in rats with a simulated acute hepatitis and correction with a thick extract from reishi mushrooms

Herasymets

Фіра

Medvid

2021

SR: BS

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The aim. To study the effect of a dry extract from reishi mushrooms on the activity of lipoperoxidation and oxidative modification of proteins under the conditions of a simulated paracetamol hepatitis in rats. Materials and methods. The study was performed on white male rats. The animals were divided into 10 groups, each included 6 animals. Acute hepatitis was simulated by the intragastric administration of paracetamol in the dose of 1250 mg/kg once per day (for 2 days). Correction of the pathology induced was performed with a dry extract of reishi mushrooms in the dose of 100 mg/kg of the body weight. The reference drug “Silybor” was administered in the dose of 20 mg/kg of the animal body weight. On Day 3, 7 and 10 from the beginning of the lesion, rats were euthanized using sodium barbamyl. The liver homogenate and blood serum were used for the studies. The activity of free radical oxidation processes under the conditions of acute toxic hepatitis and after the introduction of corrective factors was assessed by superoxide dismutase, catalase activity, the content of TBA-AP and OMP products. Results and discussion. The development of acute paracetamol hepatitis in rats and damage of hepatocyte membranes are indicated by an increase in the content of TBA-active products, products of oxidative modification of neutral and basic proteins in the serum and liver of animals. Simultaneously, a decrease in the activity of catalase and superoxide dismutase was observed. After correction of the pathology induced with a dry extract of reishi mushrooms a significant increase in the activity of antioxidant enzymes, a decrease in the content of lipid peroxidation products and oxidative modification of proteins in the serum and liver of the affected animals were observed. Conclusions. It has been experimentally proven that the use of dry extract of Reishi mushrooms in paracetamol hepatitis in rats caused a significant decrease in catalase and superoxide dismutase activity, a decrease in TBA-AP, neutral and basic 2,4-DNPH in the serum and liver of animals. The results of the research indicate an effective impact of reishi mushrooms dry extract on the normalization of lipoperoxidation, oxidative modification of proteins and antioxidant protection

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Section: Discussion Of Research Resultssupporting

confidence: 93%

Section: Discussion Of Research Resultssupporting

confidence: 91%

The study of oxidative stress indicators in rats with a simulated acute hepatitis and correction with a thick extract from reishi mushrooms

Herasymets

Фіра

Medvid

2021

SR: BS

View full text Add to dashboard Cite

show abstract

“…According to a number of studies on the use of antral, the remedy promotes the restoration of glycogen and protein-synthesizing function of the liver, improves phospholipid synthesis, activates cytochrome system, stimulates tissue respiration processes, improves energy supply and functioning of hepatocyte monooxygenase system, contri buting to the reduction of endotoxicosis intensity [11,12]. By inhibiting cyclooxygenase and reducing the synthesis of prostaglandins and other mediators of inflammation, antral exerts its anti-inflammatory effect, inhibiting the processes of free radical oxidation and enhancing the processes of neutralization of free radicals, leading to a decrease in the severity of cytolytic syndrome that prevents the destruction of hepatocytes and reduces the intensity of the inflammatory process in the bronchi [13].…”

Section: Introductionmentioning

confidence: 99%