Circadian control of neurogenesis

Goergen, Erin M.; Bagay, Leslie A.; Rehm, Kris P.; Benton, Jeanne L.; Beltz, Barbara S.

doi:10.1002/neu.10095

Cited by 74 publications

(67 citation statements)

References 36 publications

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“…Memory consolidation, in addition to increased coherence, has been suggested to be associated with increased cell proliferation in the HC during sleep [42][43][44]. Studies have shown that the Amyg influences neuronal plasticity and memory associated processes in the HC [45].…”

Section: Discussionmentioning

confidence: 99%

Reduced Theta Coherence and P Wave Ratio Linked to Memory Deficits After Sleep Deprivation in Rat Model

2017

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Purpose It is well established that loss of sleep leads to lapses in learning and memory. The brain regions including hippocampus, amygdala and the prefrontal cortex are associated with memory processes. However, there are not many studies on the changes in neuronal communications between these brain areas during sleep deprivation. Methods In this study, changes in the P waves, and theta coherence among the hippocampus, amygdala and the prefrontal cortex, were studied before and after exposing the animals to total sleep deprivation of 24 h. Changes in reference and working memory were evaluated after sleep deprivation.Results Concomitant with a rebound increase in non-REM sleep after total sleep deprivation, there was a decrease in the coherence of theta waves between all the studied areas, especially between hippocampus and amygdala. The ratio of P wave cluster to singlet was reduced. There was a decrease in 'correct memory performance' after sleep deprivation. Conclusions This study showed that after sleep deprivation, there was a correlation in the cognitive deficits and decrease in the coherence of theta waves, and the ratio of P wave cluster to singlet. Impairments in brain function, especially cognition, after sleep loss could be attributed to changes in functional connectivity between these neural networks. This study highlighted important functions of sleep in maintaining an appropriate synchrony between various neuronal networks during REM sleep.

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Section: Discussionmentioning

confidence: 99%

Reduced Theta Coherence and P Wave Ratio Linked to Memory Deficits After Sleep Deprivation in Rat Model

2017

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“…One of our major interests is the serotonergic regulation of neurogenesis in the lobster brain. We have shown that serotonin levels regulate the rate of generation of new neurons in this system Benton and Beltz, 2001) and that neurogenesis is also under circadian control (Goergen et al, 2002). We hypothesized that if serotonin is involved in the circadian pathway that regulates neurogenesis, brain levels of this molecule should also cycle diurnally, be light entrainable and show a fixed relationship to the neurogenic rhythm.…”

Section: Discussionmentioning

confidence: 99%

“…This finding may be correlated with the habits of lobsters, which are most active around dusk (Weiss, 1970;Cooper and Uzmann, 1980;Chabot et al, 2001). This rhythm of neuronal proliferation is regulated by an endogenous oscillator that is entrained by the light:dark (L:D) cycle (Goergen et al, 2002). We have proposed that light may provide a dominant coordinating signal for the many factors, including serotonin, that influence the persistent generation of new neurons.…”

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confidence: 99%

Regulation of serotonin levels by multiple light-entrainable endogenous rhythms

Wildt

Goergen

Benton

et al. 2004

Journal of Experimental Biology

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This study examined whether serotonin levels in the brain of the American lobster, Homarus americanus, are under circadian control. Using high-performance liquid chromatography and semi-quantitative immunocytochemical methods, we measured serotonin levels in the brains of lobsters at six time points during a 24-h period. Lobsters were maintained for 2·weeks on a 12·h:12·h light:dark cycle followed by 3·days of constant darkness. Under these conditions, brain serotonin levels varied rhythmically, with a peak before subjective dusk and a trough before subjective dawn. This persistent circadian rhythm in constant darkness indicates that serotonin levels are controlled by an endogenous clock. Animals exposed to a shifted light cycle for >10·days, followed by 3·days in constant darkness, demonstrate that this rhythm is light entrainable. Separate analyses of two pairs of large deutocerebral neuropils, the accessory and olfactory lobes, show that serotonin levels in these functionally distinct areas also exhibit circadian rhythms but that these rhythms are out of phase with one another. The olfactory and accessory lobe rhythms are also endogenous and light entrainable, suggesting the presence of multiple clock mechanisms regulating serotonin levels in different brain regions.

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“…Since H. americanus is mainly nocturnal (MacKenzie & Moring 1985) and the laboratory was available only during the day, lobsters were induced to reverse their day:night cycle of activity. To do so, for 2 weeks (a period shown to be sufficient to reverse the rhythm of H. americanus; Goergen et al 2000), the experimental lobsters were trained to an artificial light:dark cycle (approximately 14:10 h) with lights off at 0600 and lights on at 2000 hours. Lobsters were fed ad libitum with fish and cuttlefish minced meat.…”

Section: Experimental Design and Apparatusmentioning

confidence: 99%

Visual recognition of conspecifics in the American lobster, Homarus americanus

et al. 2010

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Keywords:aggressive behaviour Homarus americanus individual recognition lobster sight For years, individual recognition has been the subject of many studies but, owing to the intrinsic complexity of the phenomenon, it has also been the source of much controversy. The sensory channel(s) used for recognition has also been much discussed. In aquatic invertebrates, vision has been one of the least understood media. We carried out two laboratory experiments using 49 pairs of adult male American lobsters. The first experiment was aimed at investigating the sensory channel/s (smell, sight or the two combined) used by lobsters to get information about the opponent, whereas in the second experiment we tested whether visual experience might allow lobsters to recognize the familiar opponent. Previous exposure to the sight of a conspecific induced lobsters either to avoid the opponent or to skip preliminaries (approaches and threats) and escalate the interaction. However, such changes in the dynamics of fighting were shown only when the opponent was the individual that the experimental lobster had previously seen rather than a generic lobster. This is the first study to provide evidence that lobsters can identify familiar conspecifics by sight, although this does not necessarily mean that they recognize them as individuals. Further studies are needed to clarify this issue. Ó

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Circadian control of neurogenesis

Cited by 74 publications

References 36 publications

Reduced Theta Coherence and P Wave Ratio Linked to Memory Deficits After Sleep Deprivation in Rat Model

Reduced Theta Coherence and P Wave Ratio Linked to Memory Deficits After Sleep Deprivation in Rat Model

Regulation of serotonin levels by multiple light-entrainable endogenous rhythms

Visual recognition of conspecifics in the American lobster, Homarus americanus

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