Circadian Control of Inflammatory Processes in Atherosclerosis and Its Complications

Steffens, Sabine; Winter, Carla; Schloss, Maximilian J.; Hidalgo, Andrés; Weber, Christian; Soehnlein, Oliver

doi:10.1161/atvbaha.117.309374

Cited by 49 publications

(29 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accordingly, the effect of anaesthesia nearer to bedtime21 22 as well as the negative role of a longer fasting for patients operated on in the later hours19 23 have also been suggested as possible factors influencing patients’ heart recovery. Also, cell-intrinsic clocks sensible to proinflammatory stimuli, such as a surgical procedure, have been characterised in macrophages and other inflammatory cell lines involved in atherosclerotic plaque stability,24 possibly impacting on the risk of AMI in the follow-up depending on the time of the intervention.…”

Section: Discussionmentioning

confidence: 99%

Daytime variation of perioperative myocardial injury in non-cardiac surgery and effect on outcome

Lavallaz

Puelacher

Buse

et al. 2018

Heart

View full text Add to dashboard Cite

ObjectiveRecently, daytime variation in perioperative myocardial injury (PMI) has been observed in patients undergoing cardiac surgery. We aim at investigating whether daytime variation also occurs in patients undergoing non-cardiac surgery.MethodsIn a prospective diagnostic study, we evaluated the presence of daytime variation in PMI in patients at increased cardiovascular risk undergoing non-cardiac surgery, as well as its possible impact on the incidence of acute myocardial infarction (AMI), and death during 1-year follow-up in a propensity score–matched cohort. PMI was defined as an absolute increase in high-sensitivity cardiac troponin T (hs-cTnT) concentration of ≥14 ng/L from preoperative to postoperative measurements.ResultsOf 1641 patients, propensity score matching defined 630 with similar baseline characteristics, half undergoing non-cardiac surgery in the morning (starting from 8:00 to 11:00) and half in the afternoon (starting from 14:00 to 17:00). There was no difference in PMI incidence between both groups (morning: 50, 15.8% (95% CI 12.3 to 20.3); afternoon: 52, 16.4% (95% CI 12.7 to 20.9), p=0.94), nor if analysing hs-cTnT release as a quantitative variable (median morning group: 3 ng/L (95% CI 1 to 7 ng/L); median afternoon group: 2 ng/L (95% CI 0 to 7 ng/L; p=0.16). During 1-year follow-up, the incidence of AMI was 1.2% (95% CI 0.4% to 3.2%) among morning surgeries versus 4.1% (95% CI 2.3% to 6.9%) among the afternoon surgeries (corrected HR for afternoon surgery 3.44, bootstrapped 95% CI 1.33 to 10.49, p log-rank=0.03), whereas no difference in mortality emerged (p=0.70).ConclusionsAlthough there is no daytime variation in PMI in patients undergoing non-cardiac surgery, the incidence of AMI during follow-up is increased in afternoon surgeries and requires further study.Clinical trial registration NCT02573532;Results.

show abstract

Section: Discussionmentioning

confidence: 99%

Daytime variation of perioperative myocardial injury in non-cardiac surgery and effect on outcome

Lavallaz

Puelacher

Buse

et al. 2018

Heart

View full text Add to dashboard Cite

show abstract

“…The reasons for discrepancies between studies could be due to model-specific factors (e.g., rodent strain, type of exercise) or differences in cardiac perfusion protocols (e.g., substrate levels, addition of hormones). Circadian rhythm may also account for disparate findings because it influences cardiac metabolism ( 218 ), stress responses and protein turnover ( 219 ), and inflammatory processes ( 220 ). Chronobiology remains an important consideration for understanding how exercise influences cardiac biochemistry and physiology ( 221 , 222 ).…”

Section: How Does Cardiac Metabolism Change During Exercise?mentioning

confidence: 99%

Metabolic Mechanisms of Exercise-Induced Cardiac Remodeling

Fulghum

Hill²

2018

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Exercise has a myriad of physiological benefits that derive in part from its ability to improve cardiometabolic health. The periodic metabolic stress imposed by regular exercise appears fundamental in driving cardiovascular tissue adaptation. However, different types, intensities, or durations of exercise elicit different levels of metabolic stress and may promote distinct types of tissue remodeling. In this review, we discuss how exercise affects cardiac structure and function and how exercise-induced changes in metabolism regulate cardiac adaptation. Current evidence suggests that exercise typically elicits an adaptive, beneficial form of cardiac remodeling that involves cardiomyocyte growth and proliferation; however, chronic levels of extreme exercise may increase the risk for pathological cardiac remodeling or sudden cardiac death. An emerging theme underpinning acute as well as chronic cardiac adaptations to exercise is metabolic periodicity, which appears important for regulating mitochondrial quality and function, for stimulating metabolism-mediated exercise gene programs and hypertrophic kinase activity, and for coordinating biosynthetic pathway activity. In addition, circulating metabolites liberated during exercise trigger physiological cardiac growth. Further understanding of how exercise-mediated changes in metabolism orchestrate cell signaling and gene expression could facilitate therapeutic strategies to maximize the benefits of exercise and improve cardiac health.

show abstract

“…Nocturnal shiftwork alters the rhythmicity of the immune system, and such a disruption might play a role in the increased infection risk and higher incidence of autoimmune diseases, cancer, and cardiovascular and metabolic disorders (Esquirol et al, 2011 ). It has been suggested that the increase in artificial light exposure in modern societies parallels the increase in obesity prevalence, with altered circadian homeostasis clearly contributing to cardiovascular and metabolic derangements (Versteeg et al, 2016 ; Kiehn et al, 2017 ; Mayeuf-Louchart et al, 2017 ; Steffens et al, 2017 ; Tarquini and Mazzoccoli, 2017 ). Shift work, especially night work and long working hours are among the possible modifiable risk factors that influence the incidence of cardiovascular and metabolic risk factors (Puttonen et al, 2010 ; Nabe-Nielsen et al, 2017 ) and sleep (Sallinen and Kecklund, 2010 ; McHill et al, 2014 ; Givens et al, 2015 ; Wirth et al, 2017 ; Wyse et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Exosomes and Metabolic Function in Mice Exposed to Alternating Dark-Light Cycles Mimicking Night Shift Work Schedules

et al. 2017

View full text Add to dashboard Cite

Sleep is an important modulator of metabolic function. Disruptions of sleep in circadian rhythm are common in modern societies and are associated with increased risk of developing cardiometabolic disorders. Exosomes are ubiquitous extracellular vesicles that may play a mechanistic role in metabolic derangements. We hypothesized that alternating dark-light cycles mimicking shift work in mice would alter fecal microbiota and colonic epithelium permeability and alter plasma exosome cargo and metabolic function. C57BL/6 mice were randomly assigned to (i) control day light (CL), or (ii) inverted dark-light every 2 weeks for 8 weeks (IN). Body weight, fat mass and HOMA-IR were measured, along with Tregs, metabolic, and resident macrophages in visceral white adipose tissue (vWAT). Fecal water samples were incubated with confluent colonic epithelium cell cultures in electric cell-substrate impedance sensing (ECIS) arrays, and plasma exosomes were added to differentiated adipocytes and insulin-induced pAKT/AKT expression changes were assessed by western blots. Mice exposed to IN showed elevated HOMA-IR, and their fecal samples showed altered microbiota which promote increased permeability of the colonic epithelial cell barrier. Plasma exosomes decreased pAKT/AKT responses to exogenous insulin compared to CL, and altered expression of circadian clock genes. Inflammatory macrophages (Ly-6chigh) were increased in IN-exposed vWAT, while Tregs were decreased. Thus, gut microbiota and the cargo of plasma exosomes are altered by periodic shifts in environmental lighting, and effectively alter metabolic function, possibly via induction of systemic inflammation and altered clock expression in target tissues. Further exploration of exosomal miRNA signatures in shift workers and their putative metabolic organ cell targets appears warranted.

show abstract

Circadian Control of Inflammatory Processes in Atherosclerosis and Its Complications

Cited by 49 publications

References 63 publications

Daytime variation of perioperative myocardial injury in non-cardiac surgery and effect on outcome

Daytime variation of perioperative myocardial injury in non-cardiac surgery and effect on outcome

Metabolic Mechanisms of Exercise-Induced Cardiac Remodeling

Exosomes and Metabolic Function in Mice Exposed to Alternating Dark-Light Cycles Mimicking Night Shift Work Schedules

Contact Info

Product

Resources

About