Circadian Clocks: Translation Lost

Roenneberg, Till; Merrow, Martha

doi:10.1016/j.cub.2005.06.014

Cited by 5 publications

(2 citation statements)

References 50 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, cyanobacteria [58][59][60][61][62][63], fungi [20,22] and insect [64,65] circadian rhythms are originated, as in mammals, on feedback loops in which heterodimeric transcription factors act as positive elements to drive the expression of proteins that will block, once in the nucleus, the activity of those positive elements; however, cyanobacteria may present some differences [58][59][60][61]63,[66][67][68].…”

Section: Molecular Basis Of Circadian Rhythmic-ity: How Endogenous CImentioning

confidence: 99%

Chronopharmacology and Antimicrobial Therapeutics

Rebuelto

2006

CCP

View full text Add to dashboard Cite

Chronobiology studies the phenomenon of rhythmicity in living organisms. Circadian rhythms are genetically determined and are regulated by external synchronizers (i.e. light/day cycle). Several biological processes involved in the pharmacokinetics and pharmacodynamics of drugs are subject to circadian variations. Chronopharmacology studies how biological rhythms impact on drug pharmacokinetic (chronokinetics), pharmacodynamics (chronoesthesy) and toxicity and determines whether time of day administration modifies drug's pharmacological characteristics. Chronotherapy applies chronopharmacological studies to clinical treatments, determining the best biological time for its dosing, i.e. when beneficial effects are maximal and incidence and/or intensity of related side-effects and toxicity are minimal. Significant variations in the pharmacokinetics and toxicity of antibiotics (aminoglycosides, beta-lactams and fluoroquinolones) related to administration time are well known. The aims of this review are to discuss, briefly, the currently accepted model of the circadian system that substantiates endogenous rhythmicity and to provide an update on the knowledge of circadian rhythms applied to drugs used as medicines, with a special mention to the possible impact on antimicrobial treatments. It is concluded that the dosing time of an antimicrobial agent might be clinically relevant in some treatments, thus, clinicians should be aware that the dosing time might affect the clinical response of a drug.

show abstract

Section: Molecular Basis Of Circadian Rhythmic-ity: How Endogenous CImentioning

confidence: 99%

Chronopharmacology and Antimicrobial Therapeutics

Rebuelto

2006

CCP

View full text Add to dashboard Cite

show abstract

“…Moreover, cyclic KaiC phosphorylation in cyanobacteria persists in vivo independent of transcription and translation 48 . Although this could be a unique aspect of prokaryotic clocks, there are numerous indications that rhythm-generating mechanisms that are independent of rhythmic transcription and translation of clock genes exist in eukaryotes 49 .…”

Section: The Molecular Clockmentioning

confidence: 99%

Circadian clocks — the fall and rise of physiology

Roenneberg¹,

Merrow

2005

Nat Rev Mol Cell Biol

Self Cite

174

118

View full text Add to dashboard Cite

Circadian clocks control the daily life of most light-sensitive organisms - from cyanobacteria to humans. Molecular processes generate cellular rhythmicity, and cellular clocks in animals coordinate rhythms through interaction (known as coupling). This hierarchy of clocks generates a complex, approximately 24-hour temporal programme that is synchronized with the rotation of the Earth. The circadian system ensures anticipation and adaptation to daily environmental changes, and functions on different levels - from gene expression to behaviour. Circadian research is a remarkable example of interdisciplinarity, unravelling the complex mechanisms that underlie a ubiquitous biological programme. Insights from this research will help to optimize medical diagnostics and therapy, as well as adjust social and biological timing on the individual level.

show abstract

Circadian Gene Expression in the Suprachiasmatic Nucleus

Gillette

Tyan

2009

Encyclopedia of Neuroscience

View full text Add to dashboard Cite

Circadian Clocks: Translation Lost

Cited by 5 publications

References 50 publications

Chronopharmacology and Antimicrobial Therapeutics

Chronopharmacology and Antimicrobial Therapeutics

Circadian clocks — the fall and rise of physiology

Circadian Gene Expression in the Suprachiasmatic Nucleus

Contact Info

Product

Resources

About