Circadian clocks: Neural and peripheral pacemakers that impact upon the cell division cycle

Reddy, Akhilesh B.; Wong, G.C.; O’Neill, John S.; Maywood, Elizabeth S.; Hastings, Michael H.

doi:10.1016/j.mrfmmm.2005.01.024

Cited by 82 publications

(66 citation statements)

References 89 publications

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“…It is unclear why peripheral and central clocks develop so early. However, given accumulating reports on gating of cell division by the circadian clock and the proposed evolutionary link between these two systems (40), it is conceivable that this early development is important for cell cycle-dependent timed events that occur during development. In the zebrafish larvae, daily variations in cell division (34) and cell death (41) were reported.…”

Section: Discussionmentioning

confidence: 99%

Circadian time-keeping during early stages of development

Ziv¹,

Gothilf

2006

Proc. Natl. Acad. Sci. U.S.A.

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The zebrafish pineal gland is a photoreceptive organ containing an intrinsic central circadian oscillator, which drives daily rhythms of gene expression and the melatonin hormonal signal. Here we investigated the effect of light, given at early developmental stages before pineal gland formation, on the pineal circadian oscillator. Embryos that were exposed to light at 0 -6, 10 -13, or 10 -16 h after fertilization exhibited clock-controlled rhythms of arylalkylamine-N-acetyltransferase (zfaanat2) mRNA in the pineal gland during the third and fourth day of development. This rhythm was absent in embryos that were placed in continuous dark within 2 h after fertilization (before blastula stage). Differences in the phases of these rhythms indicate that they are determined by the time of illumination. Light treatments at these stages also caused a transient increase in period2 mRNA levels, and the development of zfaanat2 mRNA rhythm was abolished by PERIOD2 knock-down. These results indicate that light exposure at early developmental stages, and light-induced expression of period2, are both required for setting the phase of the circadian clock. The 24-h rhythm is then maintained throughout rapid proliferation and, remarkably, differentiation.AANAT ͉ light ͉ period2 ͉ pineal ͉ zebrafish

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Section: Discussionmentioning

confidence: 99%

Circadian time-keeping during early stages of development

Ziv¹,

Gothilf

2006

Proc. Natl. Acad. Sci. U.S.A.

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“…Circadian gene expression in fibroblasts continues during cell division, and the circadian oscillator gates cytokinesis to defined time windows; in turn, mitosis can phase-shift the circadian cycle (Nagoshi et al 2004;Reddy et al 2005;Hunt and Sassone-Corsi 2007). Another instructive observation is that among the hundreds of proteins exhibiting circadian expression patterns, several are key regulators of the cell cycle and apoptosis.…”

Section: The Cell Cyclementioning

confidence: 99%

“…For early life forms, strong UV irradiation during the day must have been a constant source of DNA damage; hence, restricting the S phase of the cell cycle to nighttime may have had an adaptive value (Woelfle et al 2004;Reddy et al 2005). In current multicellular organisms as humans and other mammals, DNA damage leading to genomic instability is a major force driving cancer.…”

Section: Dna Damagementioning

confidence: 99%

The Role of Circadian Regulation in Cancer

Gery¹,

Koeffler²

2007

Cold Spring Harbor Symposia on Quantitative Biology

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“…The daily light-dark cycle synchronizes the master circadian pacemaker, located in the suprachiasmatic nuclei (SCN) of the brain, which in turn synchronizes the organism's central clock, as well as the peripheral clocks in each cell (Reddy et al, 2005). The molecular mechanisms of circadian oscillation in the SCN and peripheral cells are based on a negative transcriptional-translational feedback loop generated by the core clock genes.…”

Section: Introductionmentioning

confidence: 99%

Deregulated Expression of Cry1 and Cry2 in Human Gliomas

Luo¹,

Fan²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Growing evidence shows that deregulation of the circadian clock plays an important role in the development of malignant tumors, including gliomas. However, the molecular mechanisms of gene chnages controlling circadian rhythm in glioma cells have not been explored. Using real time polymerase chain reaction and immunohistochemistry techniques, we examined the expression of two important clock genes, cry1 and cry2, in 69 gliomas. In this study, out of 69 gliomas, 38 were cry1-positive, and 51 were cry2-positive. The expression levels of cry1 and cry2 in glioma cells were significantly different from the surrounding non-glioma cells (P<0.01). The difference in the expression rate of cry1 and cry 2 in high-grade (grade III and IV) and low-grade (grade 1 and II) gliomas was non-significant (P>0.05) but there was a difference in the intensity of immunoactivity for cry 2 between high-grade gliomas and low-grade gliomas (r=-0.384, P=0.021). In this study, we found that the expression of cry1 and cry2 in glioma cells was much lower than in the surrounding non-glioma cells. Therefore, we suggest that disturbances in cry1 and cry2 expression may result in the disruption of the control of normal circadian rhythm, thus benefiting the survival of glioma cells. Differential expression of circadian clock genes in glioma and non-glioma cells may provide a molecular basis for the chemotherapy of gliomas.

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Circadian clocks: Neural and peripheral pacemakers that impact upon the cell division cycle

Cited by 82 publications

References 89 publications

Circadian time-keeping during early stages of development

Circadian time-keeping during early stages of development

The Role of Circadian Regulation in Cancer

Deregulated Expression of Cry1 and Cry2 in Human Gliomas

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