Circadian Clocks and Inflammation: Reciprocal Regulation and Shared Mediators

Cermakian, Nicolas; Westfall, Susan; Kiessling, Silke

doi:10.1007/s00005-014-0286-x

Cited by 71 publications

(53 citation statements)

References 183 publications

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“…These direct effects on the central nervous system and HPA axis circuits, including the amygdala, hippocampus and peripheral tissue glucocorticoid receptors, can be related with altered basal HPA axis activity. Stress reactivity patterns can also influence basal HPA axis activity indirectly through the multi-directional influence between HPA axis, immune system and circadian clock rhythm (Cermakian et al, 2014; Nader et al, 2010; Scheiermann et al, 2013). …”

Section: Discussionmentioning

confidence: 99%

HPA-axis and inflammatory reactivity to acute stress is related with basal HPA-axis activity

Chen

Gianferante

Hanlin

et al. 2017

Psychoneuroendocrinology

107

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Introduction Inflammation is drawing attention as pathway between psychosocial stress and health, and basal HPA axis activity has been suggested to exert a consistent regulatory influence on peripheral inflammation. Here we studied the relationship between basal HPA axis activity and inflammatory and HPA axis acute stress reactivity. Methods We recruited 48 healthy individuals and collected saliva for diurnal cortisol sampling at 6 points. Participants were previously exposed to the Trier Social Stress Test (TSST) on two consecutive days. Plasma interleukin-6 (IL-6) and salivary cortisol reactivity to acute stress were measured, and their relationships with basal activity were analyzed. Results Steeper cortisol awakening response (CAR) linear increase was related with stronger cortisol stress reactivity (γ=0.015; p=0.042) and marginally significantly with greater habituation (γ=0.01; p=0.066). Greater curvilinearity of CAR was related with stronger cortisol reactivity (γ=−0.014; p=0.021) and greater cortisol habituation (γ=−0.011; p=0.006). Steeper daily linear decline was related with significant or marginally significantly stronger cortisol and IL-6 reactivity (cortisol: γ=−0.0004; p=0.06; IL-6: γ=−0.028; p=0.031) and greater habituation (cortisol: γ=−0.002; p=0.009, IL-6: γ=−0.015; p=0.033). Greater curvilinearity of daily decline was related with stronger IL-6 reactivity (γ=0.002; p=0.024) and also greater cortisol and IL-6 habituation (cortisol: γ=0.00009; p=0.03, IL-6: γ=0.001; p=0.024). Conclusions Patterns of basal HPA axis activity that are related with healthier outcomes were found to be related with stronger initial cortisol and IL-6 reactivity and greater habituation. This is an important step in understanding the long-term health implications of acute stress responsiveness, and future studies should employ longitudinal designs to identify the direction of these relationships.

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Section: Discussionmentioning

confidence: 99%

HPA-axis and inflammatory reactivity to acute stress is related with basal HPA-axis activity

Chen

Gianferante

Hanlin

et al. 2017

Psychoneuroendocrinology

107

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“…In recent years, mounting evidence has demonstrated that the immune system displays circadian oscillations (see reviews (Labrecque and Cermakian 2015;Nakao 2014;Scheiermann et al 2013;Cermakian et al 2013;Cermakian et al 2014)). Pro-inflammatory cytokines are elevated during rest time and anti-inflammatory cytokines are elevated during activity time.…”

Section: Resultsmentioning

confidence: 99%

“…Recent work has shown that disruption of the circadian clock leads to dysregulation of immune responses which underlie the pathophysiological basis of disease, suggesting an important regulatory role of the circadian system. This relates to daily oscillations in the number of circulating innate and adaptive immune cells, cytokine and chemokine levels and expression of adhesion molecules that are integral components of the immune response (reviewed in (Labrecque and Cermakian 2015;Nakao 2014;Scheiermann et al 2013;Cermakian et al 2013;Cermakian et al 2014)). Overall, multiple studies suggest that pro-inflammatory activity is elevated during rest and induces sleep whereas anti-inflammatory mediators are induced upon awakening and inhibit sleep (Bryant et al 2004;Krueger 1990;Krueger et al 2001;Kushikata et al 1999;Krueger 1987;Kubota et al 2000).…”

Section: Introductionmentioning

confidence: 99%

A circadian based inflammatory response – implications for respiratory disease and treatment

Comas

Gordon

Oliver

et al. 2017

Sleep Science Practice

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Circadian clocks regulate the daily timing of many of our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in immune cell count, synthesis and cytokine release, clock gene expression in cells and organs of the immune system as well as clock-controlled genes that regulate immune function. Circadian disruption leads to dysregulation of immune responses and inflammation which can further disrupt circadian rhythms. The response of organisms to immune challenges, such as allergic reactions also vary depending on time of the day, which can lead to detrimental responses particularly during the rest and early active periods. This review evaluates what is currently known in terms of circadian biology of immune response and the cross-talk between circadian and immune system. We discuss the circadian pattern of three respiratory-related inflammatory diseases, chronic obstructive pulmonary disease, allergic rhinitis and asthma. Increasing our knowledge on circadian patterns of immune responses and developing chronotherapeutic studies in inflammatory diseases with strong circadian patterns will lead to preventive measures as well as improved therapies focussing on the circadian rhythms of symptoms and the daily variation of the patients' responses to medication.

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“…33 Circadian rhythms have a direct impact on the systemic regulation of energy metabolism and immune, 34 hormonal, 30 and cardiovascular functions. 35 Their chronic disruption increases susceptibility to inflammatory and metabolic disorders, 34,36 indicating a protective role for circadian rhythms against incidence of disease.…”

Section: Ra and Circadian Rhythmsmentioning

confidence: 99%

The Potential of Circadian Realignment in Rheumatoid Arthritis

Rao

Pierre

Schlesinger

et al. 2016

Crit Rev Biomed Eng

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In this short review, we discuss evidence supporting the modulation of peripheral circadian systems as a therapeutic strategy for rheumatoid arthritis (RA). We first review the role of proinflammatory cytokines and oxidative stress, two of the primary mediators of chronic inflammation in RA, and their regulation by circadian clock machinery. We further highlight the role of environmental and metabolic signals in regulating the central and peripheral circadian clocks, with an emphasis on seasonal variations in photoperiod and rhythmic metabolic input, respectively. Finally, we hypothesize that the entrainment and realignment of peripheral clock rhythms have the ability to modulate these mediators, improving clinical outcomes in RA patients. Our discussion emphasizes the use of light therapy and time-restricted feeding for entraining peripheral clocks either via the entrainment of the central circadian clock in suprachiasmatic nuclei (SCN) or directly by uncoupling the peripheral circadian clocks from SCN. In doing so, we highlight the use of nonpharmacologic interventions as a potential strategy for improving clinical outcomes in chronic inflammatory conditions such as RA.

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Circadian Clocks and Inflammation: Reciprocal Regulation and Shared Mediators

Cited by 71 publications

References 183 publications

HPA-axis and inflammatory reactivity to acute stress is related with basal HPA-axis activity

HPA-axis and inflammatory reactivity to acute stress is related with basal HPA-axis activity

A circadian based inflammatory response – implications for respiratory disease and treatment

The Potential of Circadian Realignment in Rheumatoid Arthritis

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