Circadian Clock, Reward and Addictive Behavior

Albrecht, Urs

doi:10.1002/9781118467831.ch15

Cited by 4 publications

(7 citation statements)

References 102 publications

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“…Since then, many have made adjustments to Rosen's definition. Dubois and Resconi's (1992) and Nadin's (2010;2012) amendments asserted that anticipatory systems can take into account past, current, and future states, as well as possible future states, which highlights the importance of predictive models with no contingencies.…”

Section: What Is Biological Anticipation?mentioning

confidence: 99%

Biological Prescience: The Role of Anticipation in Organismal Design

Deans

2024

Preprint

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Anticipation is the act of using information about the past and present to make predictions about future scenarios. As a concept, it is predominantly associated with the psychology of the human mind; however, there is accumulating evidence that diverse taxa without complex neural systems, and even biochemical networks themselves, can respond to perceived future conditions. Although predictive biological responses, such as circadian rhythms and stress preconditioning, have been extensively studied over the last century, newer research on predictive genetic networks in microbes have highlighted the existence of anticipatory processes in older, more primitive taxa. When taken together, these seemingly disparate processes can be connected based on a shared anticipatory design. This review discusses the important and often overlooked role of anticipation in the evolution of biological designs, and advocates for establishing a fundamental distinction between anticipatory and reactive processes as an effort to advance our understanding of complex biological processes.

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Section: What Is Biological Anticipation?mentioning

confidence: 99%

Biological Prescience: The Role of Anticipation in Organismal Design

Deans

2024

Preprint

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“…Prompted by published experimental reports, which indicate that CK2 protein interacts with clock proteins in circadian rhythm Szabó et al, 2013), we incorporated the molecular signaling pathways of CK2 in our model. The proposed schematic circadian-CK2 integrative model (Figure 1) is an extension of the circadian rhythm model in Drosophila, reported by Gonze et al (2002) and Albrecht (2010). This model is based on the inhibition of a nuclear clock protein (P N ) at the level of transcription of its gene into mRNA (M P ) (Albrecht, 2010).…”

Section: Description Of the Circadian Ck2 Modelmentioning

confidence: 99%

“…One such rhythm is circadian, an endogenous biological process with an oscillation of an approximately 24-h cycle ( Dalchau et al, 2018 ; Lane et al, 2023 ). The circadian rhythm is present in a wide range of living systems, such as plants, animals, fungi, and cyanobacteria ( Goldbeter, 2002 ; Gonze et al, 2002 ; Albrecht, 2010 ; Lane et al, 2023 ). Although these rhythms are self-sustained and endogenous, they can be entrained to the local environment by external factors (zeitgebers), such as daylight, temperature, and molecular fluctuations ( Zeng et al, 1996 ; Yu and Hardin, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders

Malik

Dashti

Fatima

et al. 2023

Front. Mol. Neurosci.

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IntroductionCircadian rhythm maintains the sleep–wake cycle in biological systems. Various biological activities are regulated and modulated by the circadian rhythm, disruption of which can result in onset of diseases. Robust rhythms of phosphorylation profiles and abundances of PERIOD (PER) proteins are thought to be the master keys that drive circadian clock functions. The role of casein kinase 2 (CK2) in circadian rhythm via its direct interactions with the PER protein has been extensively studied; however, the exact mechanism by which it affects circadian rhythms at the molecular level is not known.MethodsHere, we propose an extended circadian rhythm model in Drosophila that incorporates the crosstalk between the PER protein and CK2. We studied the regulatory role of CK2 in the dynamics of PER proteins involved in circadian rhythm using the stochastic simulation algorithm.ResultsWe observed that variations in the concentration of CK2 in the circadian rhythm model modulates the PER protein dynamics at different cellular states, namely, active, weakly active, and rhythmic death. These oscillatory states may correspond to distinct pathological cellular states of the living system. We find molecular noise at the expression level of CK2 to switch normal circadian rhythm to any of the three above-mentioned circadian oscillatory states. Our results suggest that the concentration levels of CK2 in the system has a strong impact on its dynamics, which is reflected in the time evolution of PER protein.DiscussionWe believe that our findings can contribute towards understanding the molecular mechanisms of circadian dysregulation in pathways driven by the PER mutant genes and their pathological states, including cancer, obesity, diabetes, neurodegenerative disorders, and socio-psychological disease.

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“…7 Zeitgebers are diverse and include some social clues, such as working time, feed schedule and the light-dark cycle, and they are an important stimulation to entrain the clock phase, and thereafter, the circadian system. 8 The feed schedule can synchronize the behavior, not only the feeding time, but also the food quantity and quality. 6 And the opposite also works: behavior can affect the metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…Alterations in the circadian cycle commonly have physiological consequences, for example, the night work with sleep deprivation can decrease the melatonin levels and may be linked to cardiometabolic and body alterations. 8 9 10 Sleep deprivation is a loss of night's sleep 11 or when the total sleep time per night is not enough, sleep is considered shorter than need. On average, short sleep lasts less than 5 or 6 hours a day.…”

Section: Introductionmentioning

confidence: 99%

Shift Work and Metabolic Syndrome Updates: A Systematic Review

2023

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Shift work can cause circadian cycles disturbances and misaligns the endogenous rhythms. The physiological variables are driven by the circadian system and, its misalignment, can impair the metabolic functions. Thus, the main objective of this study was to evaluate the metabolic alterations as a result of shift work and night work reported in articles published in the last 5 years, using the eligibility criteria both gender and indexed articles in English language. In order to execute this work, we perform a systematic review according to PRISMA guidelines and searched about Chronobiology Disorders and Night Work, both related to metabolism, in Medline, Lilacs, ScienceDirect and Cochrane. Cross-sectional, cohort and experimental studies with low risk of bias were included. We found a total of 132 articles, and, after the selection process, 16 articles remained to be analyzed. It was observed that shift work can cause circadian misalignment and, consequently, some metabolic parameters alterations such as an impaired glycemic control and insulin functioning, cortisol phase release, cholesterol fractions imbalance, changes in morphological indexes and melatonin secretion. There are some limitations, such as heterogenicity in used databases and the 5 years restriction period, because the effects of sleep disturbance may have been reported earlier. In conclusion, we suggest that shift work interferes with the sleep-wake cycle and eating patterns, which cause crucial physiological alterations that, together, can lead to metabolic syndrome.

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Circadian Clock, Reward and Addictive Behavior

Cited by 4 publications

References 102 publications

Biological Prescience: The Role of Anticipation in Organismal Design

Biological Prescience: The Role of Anticipation in Organismal Design

Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders

Shift Work and Metabolic Syndrome Updates: A Systematic Review

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