Circadian clock, diurnal glucose metabolic rhythm, and dawn phenomenon

Peng, Fei; Li, Xin; Xiao, Fang; Zhao, Ruxing; Sun, Zheng

doi:10.1016/j.tins.2022.03.010

Cited by 30 publications

(19 citation statements)

References 122 publications

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“…Nowadays, it is common to be exposed to less light during the day and more light at night because of artificial lighting, which may impair circadian system organization and disrupt sleep, resulting in widespread adverse effects on metabolic health [ 74 , 75 , 76 ]. As indicated by strong epidemiological and laboratory evidence, the circadian cycle disturbance not only causes sleep problems, but further disrupts the optimal rhythm of many physiological functions, thus increasing the risk of cardiometabolic and other related diseases [ 77 , 78 , 79 ]. Circadian misalignment increases inflammation and impairs glucose regulation, with potential relevance to CDVs and slows the recovery of them [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies

et al. 2023

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Circadian rhythms are generated by the circadian clock, a self-sustained internal timing system that exhibits 24-h rhythms in the body. Many metabolic, cellular, behavioral and physiological processes are regulated by the circadian clock in coordination with environmental cues. The present study is a comprehensive review of the currently existing evidence concerning the relationship between circadian rhythms and sleep, metabolic, and cardiovascular disorders. We thoroughly searched the online databases PubMed, Scopus, and Web of Science to find the existing clinical studies from the last twenty-three years (2000–2023). Circadian misalignment was found to be associated with an increase in the risk of metabolic disorders, cardiovascular diseases, and obesity, as well as inadequate sleep quality. In this review article, all the included studies had a strength protocol design and all of them were conducted on humans. However, the most common limitations of them were the small sample size and the short time of the intervention. In conclusion, managing the factors that disrupt the optimal function of central and peripheral clocks can help to reduce the risk of metabolic and cardiovascular diseases, improving also sleep quality. Future studies should further explore the underlying mechanisms of the interconnections between circadian clocks and sleep, metabolic, and cardiovascular disorders. This may provide new opportunities for advance chronotherapy approach.

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Section: Discussionmentioning

confidence: 99%

Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies

et al. 2023

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“…Brain and muscle Arnt-like protein-1 (BMAL1) and circadian locomotor output cycles kaput (CLOCK) are the key transcriptional activators of the mammalian clock (Drosophila homologues are dCYCLE and dCLOCK (dCLK)), and as heterodimers, they drive the expression of thousands of clock-controlled genes including genes that encode their own transcriptional repressors, PERIOD1-3 (PER1-3) and CRYP-TOCHROME1-2 (CRY1-2) (dPER and dTIMELESS (dTIM) in Drosophila) (figure 3). The molecular oscillator is critical for generating daily rhythmicity of gene expression that manifest into a range of rhythmic biological processes (reviewed in [1][2][3][4][5][6][7][8][9][10]). PTMs, especially phosphorylation, have been established as essential mechanisms for maintaining the pace of the molecular oscillator [174][175][176].…”

Section: Regulation Of Clock Proteins Within the Core Molecular Oscil...mentioning

confidence: 99%

“…In coordination with processes that are regulated by posttranscriptional mechanisms, clock-regulated rhythmic gene expression programs that are often tissue-and cell-specific produce daily rhythms in clock outputs. The outputs of animal circadian clocks are all-encompassing and include rhythmic processes such as sleep-wake cycles, feeding-fasting cycles, metabolism, hormone production and secretion, immune response, neuronal excitability and even permeability of the blood-brain barrier [3][4][5][6][7][8][9][10]. There is growing evidence that some clock outputs are themselves zeitgebers (i.e.…”

Section: Introductionmentioning

confidence: 99%

Nutrient-sensitive protein O-GlcNAcylation shapes daily biological rhythms

Liu

Chiu

2022

Open Biol.

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O-linked- N -acetylglucosaminylation (O-GlcNAcylation) is a nutrient-sensitive protein modification that alters the structure and function of a wide range of proteins involved in diverse cellular processes. Similar to phosphorylation, another protein modification that targets serine and threonine residues, O-GlcNAcylation occupancy on cellular proteins exhibits daily rhythmicity and has been shown to play critical roles in regulating daily rhythms in biology by modifying circadian clock proteins and downstream effectors. We recently reported that daily rhythm in global O-GlcNAcylation observed in Drosophila tissues is regulated via the integration of circadian and metabolic signals. Significantly, mistimed feeding, which disrupts coordination of these signals, is sufficient to dampen daily O-GlcNAcylation rhythm and is predicted to negatively impact animal biological rhythms and health span. In this review, we provide an overview of published and potential mechanisms by which metabolic and circadian signals regulate hexosamine biosynthetic pathway metabolites and enzymes, as well as O-GlcNAc processing enzymes to shape daily O-GlcNAcylation rhythms. We also discuss the significance of functional interactions between O-GlcNAcylation and other post-translational modifications in regulating biological rhythms. Finally, we highlight organ/tissue-specific cellular processes and molecular pathways that could be modulated by rhythmic O-GlcNAcylation to regulate time-of-day-specific biology.

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“…Thus, the Bedtime regimen (with NPH insulin) is prescribed, which means administering basal insulin at bedtime. The purpose of this treatment is to provide basal concentrations of the hormone to regulate glycemic levels during sleep and prevent the dawn phenomenon (a condition in which hyperglycemia occurs during sleep, especially in the late morning and early morning) (Peng, et al, 2022).…”

Section: Insulinmentioning

confidence: 99%

A minireview of pharmacotherapy of type 2 diabetes – drugs and mechanisms

Lima

Godoy

Araújo

2022

RSD

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that originates from numerous pathogenic mechanisms, all of which result in hyperglycemia. This disease is a major cause of morbidity and mortality worldwide. Effective prevention and treatment strategies for T2DM are therefore necessary. The purpose of this review was to summarize the pharmacotherapy for patients with T2DM by discussing its pathophysiology, the therapeutic classes used in treatment strategies, as well as the mechanisms of action for each one. A literature review was conducted by searching Google Scholar, PubMed, and Science Direct databases using the search terms: type 2 diabetes mellitus, insulin, AMPK, antidiabetic drugs, incretin, SGLT2, and biguanides covering studies up to 2022. The review identified and included studies including qualitative, original research articles, and randomized controlled trial designs. The results of this study are divided into drugs that increase insulin sensitivity (e.g., biguanides, and thiazolidinediones), secretagogues (e.g., sulfonylureas, and meglitinides or glinides), incretin mimetics drugs (e.g., GLP-1 receptor agonists, and DPP-4 inhibitors), drugs that cause glycosuria (e.g., SGLT2 inhibitors), drugs that prevent glucose absorption (e.g., α-glucosidase inhibitor), and insulin. This allows the readers to understand each process while keeping the paper concise.

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Circadian clock, diurnal glucose metabolic rhythm, and dawn phenomenon

Cited by 30 publications

References 122 publications

Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies

Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies

Nutrient-sensitive protein O-GlcNAcylation shapes daily biological rhythms

A minireview of pharmacotherapy of type 2 diabetes – drugs and mechanisms

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