Circadian clock: a regulator of the immunity in cancer

Zhang, Zhen; Zeng, Puhua; Gao, Wenhui; Zhou, Qing; Feng, Ting; Tian, Xuefei

doi:10.1186/s12964-021-00721-2

Cited by 48 publications

(47 citation statements)

References 118 publications

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“…In our study cohort, we found a significant underexpression of PER1/2/3, CRY1/2 and NR1D1 proteins in CRC versus normal tissue, indicating an important role of these genes in colorectal carcinogenesis. This aspect has been extensively reported in a wide range of cancers, including CRC [22,[39][40][41]. Polymorphic variants of these circadian genes might contribute to an individual's risk of developing cancer [42][43][44][45][46].…”

Section: Discussionmentioning

confidence: 90%

Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer

et al. 2021

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Colorectal cancer (CRC) is one of the most common tumours in developed countries. Although its incidence and mortality rates have decreased, its prognosis has not changed, and a high percentage of patients with CRC develop relapse (metachronous metastasis, MM, or local recurrence, LR) during their disease. The identification of these patients is very important for their correct management, but the lack of prognostic markers makes it difficult. Given the connection between circadian disruption and cancer development and progression, we aimed to analyse the prognostic significance of core circadian proteins in CRC. We measured the expression of PER1-3, CRY1-2, BMAL1 and NR1D2 in a cohort of CRC patients by immunohistochemistry (IHC) and analysed their prognostic potential in this disease. A low expression of PER2 and BMAL1 was significantly associated with metastasis at the moment of disease diagnosis, whereas a high expression of CRY1 appeared as an independent prognostic factor of MM development. A high expression of NR1D2 appeared as an independent prognostic factor of LR development after disease diagnosis. Moreover, patients with a low expression of BMAL1 and a high expression of CRY1 showed lower OS and DFS at five years. Although these markers need to be validated in larger and different ethnic cohorts, the simplicity of IHC makes these proteins candidates for personalizing CRC treatment.

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Section: Discussionmentioning

confidence: 90%

Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer

et al. 2021

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“…A series of gradual steps, called the Cancer-Immunity Cycle, are needed to iteratively inspire and expand in order for the anti-cancer immune response to effectively kill tumor cells [ 17 , 18 ]. The stimulus and inhibitory factors play a significant role in coordinately regulating every stage of the Cancer-Immunity Cycle.…”

Section: Resultsmentioning

confidence: 99%

Development and validation of prognostic model based on the analysis of autophagy-related genes in colon cancer

Wang

Lin

et al. 2021

Aging

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Background: Autophagy, a process of self-digestion, is closely related to multiple biological processes of colon cancer. This study aimed to construct and evaluate prognostic signature of autophagy-related genes (ARGs) to predict overall survival (OS) in colon cancer patients. Materials and Methods: First, a total of 234 ARGs were downloaded via The Cancer Genome Atlas (TCGA) database. Based on the TCGA dataset, differentially expressed ARGs were identified in colon cancer. The univariate and multivariate Cox regression analysis was performed to screen prognostic ARGs to construct the prognostic model. The feasibility of the prognostic model was evaluated using receiver operating characteristic curves and Kaplan-Meier curves. A prognostic model integrating the gene signature with clinical parameters was established with a nomogram. Results: We developed an autophagy risk signature based on the 6 ARGs ( ULK3, ATG101, MAP1LC3C, TSC1, DAPK1, and SERPINA1 ). The risk score was positively correlated with poor outcome and could independently predict prognosis. Furthermore, the autophagy-related signature could effectively reflect the levels of immune cell type fractions and indicate an immunosuppressive microenvironment. Conclusion: We innovatively identified and validated 6 autophagy-related gene signature that can independently predict prognosis and reflect overall immune response intensity in the colon cancer microenvironment.

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“…In the last decade, there has been a paradigm shift on the role of the immune system in cancer therapy, with several new therapies that are now FDAapproved to enhance and even engineer the immune system to attack tumors. Some of these new therapies may benefit from chronotherapy because the tumor molecular clock influences the tumor microenvironment and immune cell infiltration (Cash et al, 2021;Z. Zhang et al, 2021b).…”

Section: Circadian Regulation Of the Tumor Cell Cycle Can Affectmentioning

confidence: 99%

Circadian Rhythms, Disease and Chronotherapy

2021

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Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The adaptive value of clocks is evident when internal body clocks and daily environmental cycles are mismatched, such as in the case of shift work and jet lag or even mistimed eating, all of which are associated with physiological disruption and disease. Studies with animal and human models have also unraveled an important role of functional circadian clocks in modulating cellular and organismal responses to physiological cues (ex., food intake, exercise), pathological insults (e.g. virus and parasite infections), and medical interventions (e.g. medication). With growing knowledge of the molecular and cellular mechanisms underlying circadian physiology and pathophysiology, it is becoming possible to target circadian rhythms for disease prevention and treatment. In this review, we discuss recent advances in circadian research and the potential for therapeutic applications that take patient circadian rhythms into account in treating disease.

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Circadian clock: a regulator of the immunity in cancer

Cited by 48 publications

References 118 publications

Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer

Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer

Development and validation of prognostic model based on the analysis of autophagy-related genes in colon cancer

Circadian Rhythms, Disease and Chronotherapy

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