Circadian changes of intraocular pressure and ocular perfusion pressure after timolol or latanoprost in Caucasians with normal-tension glaucoma

Costagliola, Ciro; Parmeggiani, Francesco; Virgili, Gianni; Lamberti, Giuseppe; Incorvaia, Carlo; Perri, Paolo; Campa, Claudio; Sebastiani, Adolfo

doi:10.1007/s00417-007-0704-4

Cited by 38 publications

(31 citation statements)

References 45 publications

(67 reference statements)

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“…Previous reports on ophthalmic timolol suggest its effects on blood pressure and heart rate in spite of low plasma concentration [12][13][14] mainly during night time. It is contraindicated in patients with bronchial asthma, severe chronic obstructive pulmonary disease, and sinus bradycardia.…”

Section: Discussionmentioning

confidence: 97%

“…7,8) Although some clinical trials have reported that topical PGF2α analogs are safe, [9][10][11] they are thought to cause systemic adverse events. Some examples include ophthalmic timolol or brimonidine, which reduce systemic blood pressure by β-receptor blocking [12][13][14] or α-receptor stimulating actions. 15) It would be difficult to demonstrate the relationship using an epidemiologic study, since the systemic drug adverse events caused by eye drops are very rare.…”

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confidence: 99%

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Blood Pressure Elevation Associated with Topical Prostaglandin F2α Analogs: An Analysis of the Different Spontaneous Adverse Event Report Databases

Ohyama

Kawakami

Inoue

2017

Biological & Pharmaceutical Bulletin

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Topical prostaglandin F2α (PGF2α) analogs are widely used as the first line of therapy for glaucoma. Systemic PGF2α is suggested to increase blood pressure. Some ophthalmic formulations with β-receptor blocking or α-receptor stimulating actions are reported to cause systemic adverse events such as a decrease in heart rate and blood pressure. The objective of this study was to evaluate the association between topical Key words prostaglandin F2α analog; blood pressure elevation; spontaneous reporting database; adverse event; reporting odds ratio Glaucoma is a progressive, chronic condition prevalent worldwide that causes damage to the optic nerve, resulting in irreversible visual impairment and blindness. Based on the status of the internal drainage system, this condition is divided into two major subtypes i.e., open angle and angle closure.1) Reducing intraocular pressure (IOP) is one of the best ways to prevent the development of glaucoma, although there is a kind of open angle glaucoma in which optic neuropathy occurs without IOP exceeding the normal range. The approximate number of glaucoma patients was 60.5 million in 2010 and is estimated to increase to 79.6 million by 2020.2)

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Blood Pressure Elevation Associated with Topical Prostaglandin F2α Analogs: An Analysis of the Different Spontaneous Adverse Event Report Databases

Ohyama

Kawakami

Inoue

2017

Biological & Pharmaceutical Bulletin

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“…In a crossover study of 60 eyes of 30 newly diagnosed NTG patients, Costagliola et al 21 investigated the influence of latanoprost 0.005% and timolol 0.5% on 24-hour sitting IOP, BP, and MOPP (calculated as 2/3MAP --IOP). Although both medications significantly reduced mean circadian IOP compared to baseline, there was a difference of 1.3 mm Hg in favor of latanoprost.…”

Section: The Effect Of Topical Medications On Opp Rhythmmentioning

confidence: 99%

24-hour Intraocular Pressure and Ocular Perfusion Pressure in Glaucoma

Quaranta

Katsanos

Russo

et al. 2013

Survey of Ophthalmology

137

147

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Abstract. This review analyzes the currently available literature on circadian rhythms of intraocular pressure (IOP), blood pressure, and calculated ocular perfusion pressure (OPP) in patients with openangle glaucoma. Although adequately powered, prospective trials are not available. The existing evidence suggests that high 24-hour IOP and OPP fluctuations can have detrimental effects in eyes with glaucoma. The currently emerging continuous IOP monitoring technologies may soon offer important contributions to the study of IOP rhythms. Once telemetric technologies become validated and widely available for clinical use, they may provide an important tool towards a better understanding of longand short-term IOP fluctuations during a patient's daily routine. Important issues that need to be investigated further include the identification of appropriate surrogate measures of IOP and OPP fluctuation for patients unable to undergo 24-hour measurements, the determination of formulae that best describe the relationship between systemic blood pressure and IOP with OPP, and the exact clinical relevance of IOP and OPP fluctuation in individual patients. Despite the unanswered questions, a significant body of literature suggests that OPP assessment may be clinically relevant in a significant number of glaucoma patients. (Surv Ophthalmol 58:26--41, 2013. Ó 2013 Elsevier Inc. All rights reserved.) Key words. glaucoma circadian rhythm intraocular pressure blood pressure ocular perfusion pressure I. Physiological ConsiderationsThe principal physiological entities that affect intraocular pressure (IOP) and its characteristics are the aqueous humor (AH) dynamics in healthy and glaucomatous eyes.The production of AH involves two consecutive processes. First, a portion of the plasma that reaches the vascular plexus of the ciliary processes is filtered through the fenestrated capillaries into the interstitial space between the vessels and the ciliary epithelia. Next, a portion of the filtrate is actively secreted by the ciliary epithelial cells into the posterior chamber.In humans, these processes are affected by age, circadian rhythm, topical and systemic medications, and the presence of glaucoma. 63,64,70,109,121 The rate of AH formation decreases with age: by 15--35% between age 20 and 80 years. 15,30 The rate of AH production in humans is significantly lower at night, 99,119 attributed to decreased endogenous circulating catecholamine levels, which may partly explain the decreased nocturnal efficacy of topical 26

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“…[25][26][27] Among the topical antiglaucoma eye drops, the prostaglandin F2-alpha analogs (travoprost, latanoprost, and bimatoprost) and dorzolamide increase OPP, whereas timolol, a beta-blocker, and brimonidine do not. [28][29][30] Therefore, to investigate the effect of eye drops, both the reduction in IOP and the hemodynamic effects of the medication should be evaluated.…”

Section: Discussionmentioning

confidence: 99%

Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma

Nomura¹,

Nakakura²,

Moriwaki³

et al. 2010

OPTH

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Purpose: The effect of travoprost 0.004% on 24-hour intraocular pressure (IOP) was examined in patients with normal tension glaucoma (NTG). Subjects and methods: This study included 17 patients with newly diagnosed unilateral NTG. IOP was measured at three-hour intervals over 24 hours by Goldman applanation tonometer in patients taking topical travoprost 0.004% and was compared retrospectively with 24-hour IOP data in untreated eyes. Results: IOP values were significantly reduced at individual time points after treatment (P , 0.01). Mean 24-hour IOP, maximum 24-hour IOP, minimum 24-hour IOP, and 24-hour IOP fluctuations at baseline (mean ± SD) were 12.9 ± 2.2 mmHg, 15.4 ± 2.7 mmHg, 10.5 ± 2.2 mmHg, and 4.9 ± 1.2 mmHg, respectively, and were significantly reduced to 10.3 ± 2.0 mmHg, 12.4 ± 2.5 mmHg, 8.5 ± 1.9 mmHg (all P , 0.001), and 3.9 ± 1.5 mmHg (P , 0.05), respectively, after treatment. The rate of IOP reduction greater than 20% was 58.8% (10 eyes) for maximum 24-hour IOP and 53.0% (nine eyes) for mean 24-hour IOP. Conclusion: Travoprost reduced IOP throughout the 24-hour study period, with over half of the eyes examined showing IOP reduction exceeding 20%.

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Circadian changes of intraocular pressure and ocular perfusion pressure after timolol or latanoprost in Caucasians with normal-tension glaucoma

Cited by 38 publications

References 45 publications

Blood Pressure Elevation Associated with Topical Prostaglandin F2α Analogs: An Analysis of the Different Spontaneous Adverse Event Report Databases

Blood Pressure Elevation Associated with Topical Prostaglandin F2α Analogs: An Analysis of the Different Spontaneous Adverse Event Report Databases

24-hour Intraocular Pressure and Ocular Perfusion Pressure in Glaucoma

Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma

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