Circadian and seasonal rhythms of 5-HT receptor subtypes, membrane anisotropy and 5-HT release in hippocampus and cortex of the rat

Weiner, N.; Clement, Hans-Willi; Gemsa, Diethard; Wesemann, W.

doi:10.1016/0197-0186(92)90062-v

Cited by 41 publications

(16 citation statements)

References 25 publications

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“…Indeed some of the major neurotransmitters that have been implicated in mood regulation, including serotonin, norepinephrine and dopamine, have a circadian rhythm in their levels, release, and synthesis-related enzymes (Weiner et al, 1992;Shieh et al, 1997;Aston-Jones et al, 2001;Barassin et al, 2002;Khaldy et al, 2002;Castaneda et al, 2004;Weber et al, 2004;Malek et al, 2005). There are also circadian rhythms in the expression and activity of several of the receptors that bind these neurotransmitters, suggesting that these entire circuits are under circadian control (Kafka et al, 1983;Wesemann and Weiner, 1990;Witte and Lemmer, 1991;Coon et al, 1997;Akhisaroglu et al, 2005).…”

Section: Influence Of the Molecular Clock On Mood-related Neurotransmmentioning

confidence: 99%

Circadian genes, rhythms and the biology of mood disorders

McClung

2007

Pharmacology & Therapeutics

574

386

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For many years, researchers have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders such as bipolar disorder, major depression and seasonal affective disorder. Furthermore, some of the treatments that are currently employed to treat mood disorders are thought to act by shifting or "resetting" the circadian clock, including total sleep deprivation and bright light therapy. There is also reason to suspect that many of the mood stabilizers and antidepressants used to treat these disorders may derive at least some of their therapeutic efficacy by affecting the circadian clock. Recent genetic, molecular and behavioral studies implicate individual genes that make up the clock in mood regulation. As well, important functions of these genes in brain regions and neurotransmitter systems associated with mood regulation is becoming apparent. In this review, the evidence linking circadian rhythms and mood disorders, and what is known about the underlying biology of this association, is presented.

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Section: Influence Of the Molecular Clock On Mood-related Neurotransmmentioning

confidence: 99%

Circadian genes, rhythms and the biology of mood disorders

McClung

2007

Pharmacology & Therapeutics

574

386

View full text Add to dashboard Cite

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“…In addition, we report a possible seasonal variation in the response to 5-HT, mainly expressed in a few specimens as a remarkably high response to 5-HT in April and June. In the mouse brain, seasonal and diurnal changes in sensitivity to serotonin have been correlated to corresponding changes in the uptake, release and number of binding sites for serotonin (Rovescalli et al, 1989;Weiner et al, 1992). Seasonal fluctuations in krill bioluminesence and the behavioural implications have been reported and discussed in the literature (Mauchline, 1960), but the physiological mechanisms underlying this variation have not been investigated.…”

Section: -Htmentioning

confidence: 99%

Serotonin and nitric oxide interaction in the control of bioluminescence in northern krill, Meganyctiphanes norvegica (M. Sars)

Krönström

Dupont²,

Mallefet

et al. 2007

Journal of Experimental Biology

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“…Acetylcholine, norepinephrine, and serotonin systems in the hippocampus fluctuate with a circadian rhythm (Brunel and de Montigny 1987;Holmes et al 1995;Holmes et al 1997;Krajnak et al 2003;Leitch et al 2003;Masuda et al 2005;Matsumoto et al 1981;Mizuno et al 1991;Mizuno et al 1994;Moore and Traynor 1976;Weiner at al. 1992).…”

Section: Modulation Of Cognition By Circadian Rhythmsmentioning

confidence: 99%

Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

Pang

Miller

Fortress

et al. 2006

AGE

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Common complaints of the elderly involve impaired cognitive abilities, such as loss of memory and inability to attend. Although much research has been devoted to these cognitive impairments, other factors such as disrupted sleep patterns and increased daytime drowsiness may contribute indirectly to impaired cognitive abilities. Disrupted sleep-wake cycles may be the result of age-related changes to the internal (circadian) clock. In this article, we review recent research on aging and circadian rhythms with a focus on the senescence-accelerated mouse (SAM) as a model of aging. We explore some of the neurobiological mechanisms that appear to be responsible for our aging clock, and consider implications of this work for age-related changes in cognition.Key words aging . C-Fos . circadian rhythms . mouse . running wheel . SAMP8 . suprachiasmatic nucleus Cognitive impairments are well-known complaints of the elderly. Despite their obvious clinical importance, many questions remain unanswered. One important issue concerns whether cognitive impairments are due to direct alterations in the cognitive function, or to other difficulties that may in turn result in cognitive deficits. For example, the elderly often report poor night-time sleep quality, daytime sleepiness, lack of energy, and difficulty adjusting to a time shift (increased "jet lag"). Could these effects contribute to cognitive impairments?Although a confluence of factors may lead to poor sleep quality, etc., it is likely that one general culprit is aging of the internal (circadian) clock that regulates these behaviors (Munch et al. 2005;Turek et al. 1995;Weitzman et al. 1982). Moreover, evidence suggests that our internal clock may also mediate cognitive functioning (Antoniadis et al. 2000;Brock 1991, Stone 1989van Gool 1986;van Someren et al. 1993a). In this article, we review recent research on aging and circadian rhythms, with a focus on the senescence-accelerated mouse line. We explore some of the neurobiological mechanisms that appear to be responsible for our aging clock, and consider implications of this work for the study of age-related changes in cognition.Circadian rhythms are predictable and regularly occurring daily changes in behavior and physiological states. The term circadian, literally meaning "around a day," has its origins in two Latin words: Circa (around) and dies (day). Two defining characteristics AGE (2006) of circadian rhythms are their continued persistence in the absence of external cues in the environment and their ability to be entrained (synchronized) by environmental cues. With respect to the former property, it is the endogenous (self-sustaining) nature of circadian rhythms that engenders an internal clock. With respect to the latter property, the major external cue that serves to synchronize the circadian rhythms of humans and other mammals is light, but almost any periodic event can act as a Zeitgeber ("time-giver").Research on the biological basis of circadian rhythms in humans and other mammals implicates the s...

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Circadian and seasonal rhythms of 5-HT receptor subtypes, membrane anisotropy and 5-HT release in hippocampus and cortex of the rat

Cited by 41 publications

References 25 publications

Circadian genes, rhythms and the biology of mood disorders

Circadian genes, rhythms and the biology of mood disorders

Serotonin and nitric oxide interaction in the control of bioluminescence in northern krill, Meganyctiphanes norvegica (M. Sars)

Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

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