Circadian and seasonal rhythms in α- and β-adrenergic receptors in the rat brain

Kafka, Marian S.; Wirz‐Justice, Anna

doi:10.1016/0006-8993(81)90373-5

Cited by 117 publications

(26 citation statements)

References 11 publications

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“…Previous studies have shown that there are circadian fluctuations in EEG vigilance pattern [12] as well as in ct|-adrenergic binding [8]. Therefore, it could be ex pected that the results of the 8-hour EEG experiment may not be identical to those of the 48-hour experiment.…”

Section: Discussionmentioning

confidence: 94%

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Effects of the Selective α<sub>1</sub>-Adrenoceptor Blocker Prazosin on EEG Sleep and Waking Stages in the Rat

Kleinlogel¹

1989

Neuropsychobiology

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In order to gain a better understanding of the role of the noradrenergic system in the control of the EEG sleep-waking stages, the effects of the selective α₁-antagonist prazosin was investigated in the rat. Oral doses of prazosin (0.1–10 mg/kg) were administered that have been shown to enter the brain. EEG sleep and waking stages were recorded either during 8 h after drug administration at 8.00 in the morning or during 48 h after drug administration at 16.00 in the afternoon. It was found that prazosin at doses of 0.1–10 mg/kg shortened quiet waking. Starting at 1 mg/kg paradoxical sleep (PS) was shortened and, most interestingly, active waking and slow wave sleep (SWS) were prolonged. PS spindles and dozing were shortened after a latency of some hours during the 48-hour experiment. However, during the 8-hour experiment PS spindles were prolonged at 0.32 and 1 mg/kg. These data suggest that in the rat α₁-adrenoceptor inhibition in the brain allows the occurrence of active waking and SWS and suppresses PS.

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Section: Discussionmentioning

confidence: 94%

“…Pre sumably the effects of the rapidly increasing doses of prazosin cover the spontaneously occurring rhythmicity. The circadian fluctuations of the apbinding is also sea sonally modified during the year [8]. Because our sleep studies were performed all over the year eventual differ ent effects of prazosin might have been smoothed.…”

Section: Discussionmentioning

confidence: 99%

Effects of the Selective α<sub>1</sub>-Adrenoceptor Blocker Prazosin on EEG Sleep and Waking Stages in the Rat

Kleinlogel¹

1989

Neuropsychobiology

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“…Nonetheless, an alteration of circadian rhythmicity of several variables has been documented in specific seasons in laboratory rodents kept in a standardized environment. This was notably the case for the number of brain receptors for several neurotransmitters (46,47), the number of committed bone marrow stem cells (48), and host tolerance for the anticancer agent cis-dichlorodiammineplatinum (49). In healthy men, the circadian rhythmicity in plasma luteinizing hormone was lacking in the first half of the year in two independent studies (27, 28) and the circadian acrophase in plasma testosterone occurred -6 h later in summer as compared with winter (26).…”

Section: Discussionmentioning

confidence: 99%

Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.

Lévi

Canon²,

Touitou³

et al. 1988

J. Clin. Invest.

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“…A large number of physiological rhythmic variables are apparent in the central nervous system, in hormone secretion, and so on (Thomson et al, 1980;Kafka et al, 1981). In addition, many drugs vary in potency and/or toxicity according to the time in the circadian cycle when they are administered (Walker and Owasoyo, 1974;Frederickson et al, 1977;Ohdo et al, 1995Ohdo et al, , 1996Ohdo et al, , 2001).…”

mentioning

confidence: 99%

Chronopharmacological Study of Antidepressants in Forced Swimming Test of Mice

Ushijima

Sakaguchi

Sato

et al. 2005

J Pharmacol Exp Ther

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The influence of dosing time on the anti-immobility effect of antidepressants and mechanisms underlying this phenomenon were investigated in mice. In the forced swimming test (FST), the immobility time of mice treated with amitriptyline (15 mg/kg) and fluvoxamine (30 mg/kg) showed a significant 24-h rhythm. The anti-immobility effect of fluvoxamine in FST was potent at the early part of the dark phase without increasing locomotor activity. Concerning pharmacokinetics, although K e of fluvoxamine was approximately 1.3-fold higher in mice injected with fluvoxamine at 9:00 PM than at 9:00 AM, no dosing time dependence was demonstrated for either plasma or brain fluvoxamine concentration at 0.5 h after the drug injection. On the other hand, serotonin transporter (SERT) mRNA expression and 5-hydroxytryptamine (5-HT) uptake activity in the mouse midbrain showed significant time-dependent changes with higher levels during the dark phase and lower levels during the light phase. These results suggest that the reuptake of 5-HT might be more increased during the dark phase. Since the reuptake of 5-HT is inhibited almost completely by injection with 30 mg/kg fluvoxamine at any time, the extracellular 5-HT level may be more increased by the injection of fluvoxamine at the early part of the dark phase. The present results suggest that the antiimmobility effect of fluvoxamine in FST increases depending on dosing time. Furthermore, the time-dependent change of SERT mRNA expression and uptake activity in the midbrain is suggested to be the mechanism underlying the 24-h rhythm of anti-immobility effect of fluvoxamine.

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Circadian and seasonal rhythms in α- and β-adrenergic receptors in the rat brain

Cited by 117 publications

References 11 publications

Effects of the Selective α<sub>1</sub>-Adrenoceptor Blocker Prazosin on EEG Sleep and Waking Stages in the Rat

Effects of the Selective α<sub>1</sub>-Adrenoceptor Blocker Prazosin on EEG Sleep and Waking Stages in the Rat

Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.

Chronopharmacological Study of Antidepressants in Forced Swimming Test of Mice

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