Circadian Activity of Topical 0.05% Betamethasone Dipropionate in Human Skin In Vivo

Pershing, Lynn K.; Corlett, Judy L.; Lambert, Lyssa D.; Poncelet, Craig E.

doi:10.1111/1523-1747.ep12376062

Cited by 32 publications

(22 citation statements)

References 14 publications

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“…The rate at which nicotine penetrates the skin was severalfold faster at 04: 00 than in the afternoon [25] . The activity of a popular topical anti-infl ammatory corticosteroid cream medication was greater when applied in the afternoon than morning [26] . A diurnal variation in the plasma testosterone concentrations was observed with two 37-cm 2 permeation-enhanced transdermal patches applied nightly at 10 p.m. [27] .…”

Section: In Vivo Evaluation In Healthy Volunteersmentioning

confidence: 99%

In vivo Evaluation of Limonene-Based Transdermal Therapeutic System of Nicorandil in Healthy Human Volunteers

Krishnaiah

Chandrasekhar

Rama

et al. 2005

Skin Pharmacol Physiol

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Hydroxypropyl methylcellulose (HPMC) gel drug reservoir system prepared with 70:30 v/v ethanol-water solvent system containing 6% w/w of limonene was effective in promoting the in vitro transdermal delivery of nicorandil. The objective of the present study was to fabricate and evaluate a limonene-based transdermal therapeutic system (TTS) for its ability to provide the desired steady-state plasma concentration of nicorandil in human volunteers. The in vitro permeation of nicorandil from a limonene-based HPMC gel drug reservoir was studied across excised rat skin (control), EVA2825 membrane, adhesive-coated EVA2825 membrane and adhesive-coated EVA2825 membrane-excised rat skin composite to account for their effect on the desired flux of nicorandil. The flux of nicorandil from the limonene-based HMPC drug reservoir across EVA2825 membrane decreased to 215.8 ± 9.7µg/cm²·h when compared to that obtained from control, indicating that EVA2825 was effective as a rate-controlling membrane. The further decrease in nicorandil flux across adhesive-coated EVA2825 membrane and adhesive-coated EVA2825 membrane-excised rat skin composite showed that the adhesive coat and skin also controlled the in vitro transdermal delivery. The limonene-based drug reservoir was sandwiched between adhesive-coated EVA2825-release liner composite and a backing membrane. The resultant sandwich was heat-sealed as circle-shaped patch (20 cm²), trimmed and subjected to in vivo evaluation in human volunteers against immediate-release tablets of nicorandil (reference formulation). The fabricated limonene-based TTS of nicorandil provided a steady-state plasma concentration of 21.3 ng/ml up to 24 h in healthy human volunteers. It was concluded that the limonene-based TTS of nicorandil provided the desired plasma concentration of the drug for the predetermined period of time with minimal fluctuations and improved bioavailability.

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Section: In Vivo Evaluation In Healthy Volunteersmentioning

confidence: 99%

In vivo Evaluation of Limonene-Based Transdermal Therapeutic System of Nicorandil in Healthy Human Volunteers

Krishnaiah

Chandrasekhar

Rama

et al. 2005

Skin Pharmacol Physiol

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“…Chronobiological parameters are currently being used in assessing the right time point for the application of a pharmaceutical dosing time for certain medications, or the best time point for obtaining certain reactions (e.g. assessing allergic reactions or drug activity) [10][11][12] to optimize large clinical studies and the development of pharmaceuticals. Different chronobiological rhythms play a role depending on the parameters or pathologies being evaluated.…”

Section: Cosinormentioning

confidence: 99%

“…In a study conducted to evaluate the dependency of the time of day of the application of betamethasone dipropionate, Pershing et al [10] observed more extensive and prolonged effects over the course of the day when the drug was applied at 16: 00 h than when applied at 09: 00 h. Maximal skin-blanching effects were observed 6 h after application which would coincide with circadian increases in TEWL in the evening and at night. TEWL is a measure of skin barrier function -an increase in comparison to baseline values is considered to be a marker of skin barrier perturbation.…”

Section: Chronobiology and Clinical Implicationsmentioning

confidence: 99%

Chronobiology: Biological Clocks and Rhythms of the Skin

Mehling¹,

Fluhr

2006

Skin Pharmacol Physiol

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The cyclicity of time affects virtually all aspects of our being and is the basis of the underlying rhythmicity which is typical of our lives. To ‘tell time’, most living organisms use internal timing mechanisms known as ‘biological clocks’. These ‘clocks’ coordinate our physiological and behavioral functions and interactions with our environment. One of the strongest influences on rhythmicity is the solar day. The study of these temporal rhythms in biological systems has been coined chronobiology. With the present article we aim to give an overview on chronobiology. Examples of chronobiological effects on skin will be described. Particular emphasis will be placed on circadian rhythms (including rhythms that take place within a 24-hour period, including so-called infradian and/or diurnal rhythms) but also on seasonal variations (circaannual rhythms).

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“…This color scale has been previously demonstrated to correlate well with the skin blanching response across many corticosteroids in a variety of vehicle bases. [9][10][11][12]14 Ventral forearm stratum corneum was harvested with adhesive discs either prepared in our laboratory or purchased commercially. An 8-mmdiameter disposable biopsy punch (Acu-Punch 1 ; Acuderm, Ft. Lauderdale, FL) was used to generate multiple discs from Transpore TM adhesive tape (3M, St. Paul, MN) in our laboratory by trained staff.…”

Section: Experimental Section Materialsmentioning

confidence: 99%

“…3 The skin blanching response was measured as the loss of skin color at the treatment site by the reflectance colorimeter a* scale. [9][10][11][12] Thus, increasing skin blanching responses are associated with decreasing colorimeter a* scale values. The skin blanching response was measured simultaneously in the above subjects at baseline, immediately after residual product removal, and again 2, 4, 6, 18, 20, 22, and 24 h after residual product removal, using the reflectance colorimeter a* scale.…”

Section: Skin Blanching Response Assessmentmentioning

confidence: 99%

Comparison of Skin Stripping, in vitro Release, and Skin Blanching Response Methods to Measure Dose Response and Similarity of Triamcinolone Acetonide Cream Strengths from Two Manufactured Sources

Pershing

Bakhtian

Poncelet

et al. 2002

Journal of Pharmaceutical Sciences

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Circadian Activity of Topical 0.05% Betamethasone Dipropionate in Human Skin In Vivo

Cited by 32 publications

References 14 publications

In vivo Evaluation of Limonene-Based Transdermal Therapeutic System of Nicorandil in Healthy Human Volunteers

In vivo Evaluation of Limonene-Based Transdermal Therapeutic System of Nicorandil in Healthy Human Volunteers

Chronobiology: Biological Clocks and Rhythms of the Skin

Comparison of Skin Stripping, in vitro Release, and Skin Blanching Response Methods to Measure Dose Response and Similarity of Triamcinolone Acetonide Cream Strengths from Two Manufactured Sources

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