Circadian actigraphic rest–activity rhythms following surgery for endometrial cancer: A prospective, longitudinal study

Abstract

Objective To investigate (1) circadian rest-activity rhythm disturbances among endometrial cancer patients as they recover from surgery in comparison to a historical reference group of women with no cancer history; and (2) health- and treatment-related predictors of dysregulated rest-activity rhythms in endometrial cancer patients. Methods 60 endometrial cancer patients participated in a prospective, longitudinal study with actigraphic assessment at 1 week, 1 month, and 4 months post-surgery. 60 women without cancer from an epidemiological sample completed one actigraphic assessment, acting as a reference group. Results On average, results revealed initial significant rest-activity dysregulation at 1 week and 1 month post-surgery for the endometrial cancer group and then significant recovery in rest-activity patterns at 4 months post-surgery. Similarly, the cancer group had significantly more impaired rhythms than the reference group at 1 week post-surgery, but demonstrated comparable rhythms by 4 months post-surgery. Among the health and treatment-related variables examined, obesity and receipt of more invasive surgery were found to predict more impaired rhythms at all time points. Conclusion(s) The current study highlights significant disturbances in rest-activity patterns for endometrial cancer patients initially during surgical recovery followed by improvement in these patterns by 4 months post-surgery; however, obese patients and those having more invasive surgery demonstrated more impaired rest-activity patterns throughout the 4-month recovery period. Further research is warranted to understand how more impaired rest-activity patterns relate to health and quality of life outcomes.

Rest–Activity Patterns in Older Adults with Heart Failure and Healthy Older Adults

“…Other symptoms not measured, such as pain or fatigue, could also contribute to some of the observed differences between the groups. The findings of lower mesor and amplitude match what has been found in a group of women with endometrial cancer, post-surgery, compared to women without a history of cancer (Rumble et al, 2015). This is the first study to compare the mesor and amplitude rest-activity patterns in HF to a group of healthy older adults.…”

Longitudinal assessment of post-surgical physical activity in endometrial and ovarian cancer patients

“…Patient assessments, including self-report measures of quality life, accelerometer evaluation of rest and activity patterns were completed one week, four weeks, and four months after surgery. Detailed methods have been previously described by Rumble, et al [28]. Participants were included in this analysis if they had valid accelerometer assessments for at least two of the three time points during their post-operative care.…”

Environmental Noise and Sleep Disturbance: Night-to-Night Variability of Sleep/Wake Pattern

“…From the noise and sleep data collected for a total of 175 nights from 35 subjects (5 nights × 35 subjects), we selected data of 108 nights of 22 subjects, where at least 80% actigraphy sleep data was obtained of each night, to ensure that each period was not missing a large portion of data. 10 The Movement Index is the percentage of epochs with y-axis counts greater than zero in the sleep period, the Fragmentation Index is the percentage of one minute periods of sleep vs. all periods of sleep during the sleep period, and the Total Sleep Fragmentation Index is the sum of the Movement Index and the Fragmentation Index.…”