Circ_SEC61A1 contributes to the progression of multiple myeloma cells via regulating miR-660-5p/CDK6 axis

Luo, Zimian; Yin, Yuqin; Tan, Xiaojun; Liu, Kang; Chen, Zhi; Xia, Hong

doi:10.1016/j.leukres.2021.106774

Cited by 3 publications

(6 citation statements)

References 43 publications

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“…circSEC61A1 is upregulated in multiple myeloma and promotes the progression of multiple myeloma 9 . We performed gain‐ and loss‐of‐function experiments to investigate the regulatory effect of circSEC61A1 on NSCLC cell function.…”

Section: Discussionmentioning

confidence: 99%

“…Circular RNAs (circRNAs) are highly abundant, stable, and tissue‐specifically expressed, 7 of which the dysregulation contributes to NSCLC progression, such as metastasis, suggesting their use as effective and specific biomarkers in the diagnosis, prognosis, and therapeutic targeting of NSCLC 8 . CircRNA Sec61 subunit alpha isoform 1 (circSEC61A1) has been studied to accelerate the progression of multiple myeloma 9 . Nevertheless, the mechanism of circSEC61A1 in NSCLC has not been fully studied.…”

Section: Introductionmentioning

confidence: 99%

“…8 CircRNA Sec61 subunit alpha isoform 1 (circSEC61A1) has been studied to accelerate the progression of multiple myeloma. 9 Nevertheless, the mechanism of circSEC61A1 in NSCLC has not been fully studied.…”

mentioning

confidence: 99%

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Circular RNA Sec61 subunit alpha isoform 1 by competitive absorption of microRNA‐513a‐5p mediates peroxisomal biogenesis factor 5 expression and promotes the malignant phenotype of non‐small cell lung cancer

Duan¹,

Yu²,

Wei³

2022

The Kaohsiung J of Med Scie

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Circular RNAs (circRNAs) are functional RNAs in the development and metabolism of non-small cell lung cancer (NSCLC). Therein, this paper particularly elucidated the circRNA SEC61 subunit alpha isoform 1 (circSEC61A1) in NSCLC has not been fully elucidated.Clinical analysis of circSEC61A1 expression was performed on specimens collected from 51 patients with primary NSCLC, together with patients' survival. Cell experiments were performed after interfering with circSEC61A1, microRNA (miR)-513a-5p, and peroxisomal biogenesis factor 5 (PEX5) expression, respectively, and cell malignant phenotypes and aerobic glycolysis were evaluated, as well as epithelial-to-mesenchymal transition (EMT)-related markers and Wnt/β-catenin pathway. Xenografts experiments studied the performance of circSEC61A1 in vivo. The downstream molecules of circSEC61A1 were searched. Our data demonstrated that circSEC61A1 was upregulated in NSCLC patients, showing an association with poorer survival outcomes. In cell experiments, cir-cSEC61A1 overexpression promoted NSCLC malignant phenotypes, glycolysis, EMT, and Wnt/β-catenin pathway activation, whereas circSEC61A1 underexpression did the opposite. Knockdown of circSEC61A1 limited tumor growth and metastasis. Furthermore, circSEC61A1 could regulate PEX5 expression through competitive absorption of miR-513a-5p. Generally, circSEC61A1 is a potential biomarker for NSCLC, and cir-cSEC61A1 serves tumor-promoting action in the progression of NSCLC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Circular RNA Sec61 subunit alpha isoform 1 by competitive absorption of microRNA‐513a‐5p mediates peroxisomal biogenesis factor 5 expression and promotes the malignant phenotype of non‐small cell lung cancer

Duan¹,

Yu²,

Wei³

2022

The Kaohsiung J of Med Scie

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“…Besides, circCHEK1_246aa, a circular CHEK1 RNA, was secreted by MM cells and was proved to increase the invasive potential of MM cells ( Gu et al, 2021 ). A current study manifested that circ_SEC61A1 level was increased in MM tissues and cells, which could aggravate MM progression at least partially by regulating miR-660-5p/CDK6 axis ( Luo et al, 2021 ). Further evidence confirmed that circ_SEC61A1 sponged miR-660-5p to increase CDK6 expression, promoting the proliferation and metastasis and restraining the apoptosis of MM cells ( Luo et al, 2021 ).…”

Section: Circrnas In MMmentioning

confidence: 98%

“…A current study manifested that circ_SEC61A1 level was increased in MM tissues and cells, which could aggravate MM progression at least partially by regulating miR-660-5p/CDK6 axis ( Luo et al, 2021 ). Further evidence confirmed that circ_SEC61A1 sponged miR-660-5p to increase CDK6 expression, promoting the proliferation and metastasis and restraining the apoptosis of MM cells ( Luo et al, 2021 ). Recently, circHNRNPU, encoding a novel protein named as circHNRNPU_603aa, was associated with poor outcomes in four independent MM patient cohorts, and overexpressed circHNRNPU_603aa promoted MM cell proliferation by regulating the bone marrow microenvironment and alternative splicing ( Tang et al, 2022 ).…”

Section: Circrnas In MMmentioning

confidence: 98%

Comprehensive elaboration of circular RNA in multiple myeloma

et al. 2022

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Circular RNAs (circRNAs), a novel category of endogenous non-coding RNAs, are usually well conserved across different species with a covalent closed-loop structure. Existing and emerging evidence confirms that circRNAs can function as regulators of alternative splicing, microRNA and RNA-binding protein sponges and translation, as well as gene transcription. In consideration of their multi-faceted functions, circRNAs are critically involved in hematological malignancies including multiple myeloma (MM). In particular, circRNAs have been found to play vital roles in tumor microenvironment and drug resistance, which may grant them potential roles as biomarkers for MM diagnosis and targeted therapy. In this review, we comprehensively elaborate the current state-of-the-art knowledge of circRNAs in MM, and then focus on their potential as biomarkers in diagnosis and therapy of MM.

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Non-coding RNAs and exosomal ncRNAs in multiple myeloma: An emphasis on molecular pathways

Hashemi

Roshanzamir

Paskeh

et al. 2023

European Journal of Pharmacology

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Circ_SEC61A1 contributes to the progression of multiple myeloma cells via regulating miR-660-5p/CDK6 axis

Cited by 3 publications

References 43 publications

Circular RNA Sec61 subunit alpha isoform 1 by competitive absorption of microRNA‐513a‐5p mediates peroxisomal biogenesis factor 5 expression and promotes the malignant phenotype of non‐small cell lung cancer

Circular RNA Sec61 subunit alpha isoform 1 by competitive absorption of microRNA‐513a‐5p mediates peroxisomal biogenesis factor 5 expression and promotes the malignant phenotype of non‐small cell lung cancer

Comprehensive elaboration of circular RNA in multiple myeloma

Non-coding RNAs and exosomal ncRNAs in multiple myeloma: An emphasis on molecular pathways

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