Circ_LPAR3 promotes the progression of oral squamous cell carcinoma (OSCC)

Li, Li; Yin, Yuan; Nan, Fanglong; Ma, Zeyu

doi:10.1016/j.bbrc.2021.12.012

Cited by 12 publications

(7 citation statements)

References 33 publications

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“…20 For example, multiple circRNAs, such as circFNDC3B, circEPSTI1, and circ_LPAR3, have been identified as strong promoters in OSCC progression and metastasis. [21][22][23] Moreover, circ_0069313 contributes to OSCC immunity escape to induce this disease progression by targeting miR-325-3p/Foxp3 axis. 24 Circ-ILF2 causes M2 macrophage polarization to enhance cancer cell resistance to cisplatin.…”

Section: Discussionmentioning

confidence: 99%

The novel circ_0004674/miR‐139‐5p/ZBTB2 regulatory cascade inhibits the development of oral squamous cell carcinoma

Qi,

Zhang,

Wang

2024

Head & Neck

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BackgroundCircular RNAs (circRNAs) are an intriguing family of RNA molecules due to their crucial roles in the pathogenesis of oral squamous cell carcinoma (OSCC). Here, we sought to define the action of human circ_0004674 in OSCC progression.MethodsThe functional role of circ_0004674 was validated by determining its effect on cell growth, apoptosis, and tube formation ability of OSCC cells. For protein quantification, a western blot or immunohistochemistry method was applied. The interaction between miR‐139‐5p and circ_0004674 or zinc finger and BTB domain containing 2 (ZBTB2) was predicted by online algorithms, and their relationships were confirmed by dual‐luciferase reporter and RIP assays. Xenograft models were established to uncover circ_0004674's role in tumor growth.ResultsCirc_0004674 expression was upregulated in OSCC. Functionally, knocking down circ_0004674 led to suppressed OSCC cell progression in vitro and delayed tumor growth in vivo. Mechanistically, circ_0004674 post‐transcriptionally controlled ZBTB2 expression by competitively pairing to miR‐139‐5p. Furthermore, the deficiency of miR‐139‐5p abated circ_0004674 silencing‐mediated OSCC cell progression repression, and augmentation of ZBTB2 reversed the anticancer effect of miR‐139‐5p on OSCC.ConclusionOur findings uncover a novel regulatory cascade, the circ_0004674/miR‐139‐5p/ZBTB2 axis, with the ability to affect OSCC development in vitro and in vivo, providing a potential opportunity for development of OSCC therapy.

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Section: Discussionmentioning

confidence: 99%

The novel circ_0004674/miR‐139‐5p/ZBTB2 regulatory cascade inhibits the development of oral squamous cell carcinoma

Qi,

Zhang,

Wang

2024

Head & Neck

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“…CircLPAR3 knockdown led to more keratin pearls in tumor tissues and inhibited the expression of CD34, a canonical protein marker of micro-vessel density. Furthermore, VEGFC and p-AKT1 were inhibited in tumors where circLPAR3 was downregulated, suggesting that the knockdown of circLPAR3 inhibits angiogenesis and tumor growth [ 121 ].…”

Section: Biological Functions Of Circrnas In Osccmentioning

confidence: 99%

CircRNAs: A Promising Star for Treatment and Prognosis in Oral Squamous Cell Carcinoma

Zhu,

Chen,

Ruan

et al. 2023

IJMS

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CircRNAs are a class of endogenous long non-coding RNAs with a single-stranded circular structure. Most circRNAs are relatively stable, highly conserved, and specifically expressed in tissue during the cell and developmental stages. Many circRNAs have been discovered in OSCC. OSCC is one of the most severe and frequent forms of head and neck cancer today, with a poor prognosis and low overall survival rate. Due to its prevalence, OSCC is a global health concern, characterized by genetic and epigenomic changes. However, the mechanism remains vague. With the advancement of biotechnology, a large number of circRNAs have been discovered in mammalian cells. CircRNAs are dysregulated in OSCC tissues and thus associated with the clinicopathological characteristics and prognosis of OSCC patients. Research studies have demonstrated that circRNAs can serve as biomarkers for OSCC diagnosis and treatment. Here, we summarized the properties, functions, and biogenesis of circRNAs, focusing on the progress of current research on circRNAs in OSCC.

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“…Oral cancer is a prevalent form of cancer that affects the mouth, tongue, and throat, and can have reduced a patient's lifetime. OSCC is the predominant subtype of oral cancer, accounting for more than 90% of all cases [1][2][3]. Experts cannot accurately predict OSCC due to the absence of specific clinical vital signs, which is a main danger related with this type of disease.…”

Section: Introductionmentioning

confidence: 99%

Adaptive Coati Deep Convolutional Neural Network-based Oral Cancer Diagnosis in Histopathological Images for Clinical Applications

Dharani

2023

Preprint

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Oral cancer is common cancer that appears in the mouth, posing a significant threat to public health due to its high mortality rate. Oral Squamous Cell Carcinoma (OSCC) is the most prevalent type of oral cancer, accounting for most cases, and it holds the seventh position among all types of cancers worldwide. Detecting OSCC early on is crucial to increase the chances of successful treatment and improve patients' survival rates. However, traditional diagnosis methods such as biopsy, where small tissue samples are extracted from the affected area and tested under a microscope, are time-consuming and require expert analysis. Moreover, due to the heterogeneity of OSCC, accurate diagnosis is challenging, and there is a need for alternative approaches to enhance the detection result of OSCC images. Therefore, this work develops two new approaches for segmenting and identifying OSCC with deep learning techniques named Mask Mean Shift CNN, named MMShift-CNN. The proposed MMShift-CNN approach attained the highest results in segmenting the OSCC region from the input image by retrieving color, texture, and shape features. The novel proposed method attained better performance with accuracy, F-measure, MSE, precision, sensitivity, and specificity of 0.9883, 0.9883, 0.0117, 0.999, 0.9867, and 0.99, respectively. These results reveal the efficiency of the proposed approach in accurately detecting oral cancer and potentially improving the efficiency of oral cancer diagnosis.

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Circ_LPAR3 promotes the progression of oral squamous cell carcinoma (OSCC)

Cited by 12 publications

References 33 publications

The novel circ_0004674/miR‐139‐5p/ZBTB2 regulatory cascade inhibits the development of oral squamous cell carcinoma

The novel circ_0004674/miR‐139‐5p/ZBTB2 regulatory cascade inhibits the development of oral squamous cell carcinoma

CircRNAs: A Promising Star for Treatment and Prognosis in Oral Squamous Cell Carcinoma

Adaptive Coati Deep Convolutional Neural Network-based Oral Cancer Diagnosis in Histopathological Images for Clinical Applications

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