“…CircRNAs can act as oncogenes or tumor suppressor genes and are strongly linked to the development and metastasis of BC 4 , 5 , 6 , 7 and other types of tumors. 8 , 9 , 10 CircRNAs can act by sponging microRNAs (miRNAs), 11 encoding proteins, 12 , 13 and regulating parental genes. 14 , 15 , 16 CircZCCHC2, a 374 bp-long-circRNA derived from exons 2–5 of the ZCCHC2 transcript (chr18: 60206913–60217693), has previously been reported to be associated with hepatocellular carcinoma, 17 while its potential role in BC has not been investigated to date.…”