2021
DOI: 10.2147/cmar.s293823
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Abstract: Background:The incidence of cholangiocarcinoma (CCA) is on the rise in recent years, and its pathogenesis may be associated with the deregulation of circular RNAs (circRNAs). Hence, we aimed to investigate the role of circRNA homeodomain interacting protein kinase 3 (circ_HIPK3) in CCA. Methods: The expression of circ_HIPK3, miR-148a-3p and unc-51 like kinase 3 (ULK1) mRNA was detected using quantitative real-time polymerase chain reaction (qPCR). The role of circ_HIPK3 in cell proliferation was detected by 3-… Show more

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Cited by 5 publications
(2 citation statements)
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“…The let-7d-5p and mir-196b-5p miRNAs have proliferation-inducing functions [ 35 , 36 ]. In contrast, the seven downregulated miRNAs (hsa-miR-10a-5p, hsa-miR-10b-5p, hsa-miR-148a-3p, hsa-miR-151a-3p, hsa-miR-196a-5p, hsa-miR-29c-3p, and hsa-miR-654-3p), if expressed, have anti-proliferative, anti-angiogenetic, and pro-inflammatory action [ 37 , 38 , 39 , 40 , 41 , 42 ]. It can be assumed that the downregulation of these miRNAs in HUVEC-sEVs serves to promote proliferation and prevent inflammation in the recipient cells.…”
Section: Discussionmentioning
confidence: 99%
“…The let-7d-5p and mir-196b-5p miRNAs have proliferation-inducing functions [ 35 , 36 ]. In contrast, the seven downregulated miRNAs (hsa-miR-10a-5p, hsa-miR-10b-5p, hsa-miR-148a-3p, hsa-miR-151a-3p, hsa-miR-196a-5p, hsa-miR-29c-3p, and hsa-miR-654-3p), if expressed, have anti-proliferative, anti-angiogenetic, and pro-inflammatory action [ 37 , 38 , 39 , 40 , 41 , 42 ]. It can be assumed that the downregulation of these miRNAs in HUVEC-sEVs serves to promote proliferation and prevent inflammation in the recipient cells.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the prognostic values of various molecules including gene, miRNAs, and circRNAs were reported to be involved in CCA [ 28 ]. CircRNAs, a novel type of RNA, have a covalent closed-loop structure that plays important roles in many tumors, including CCA.…”
Section: Discussionmentioning
confidence: 99%