circ_0001461 promotes oral squamous cell carcinoma progression through miR-145/TLR4/NF-κB axis

Ai, Yilong; Song, Jing; Wei, Haigang; Tang, Zhe; Li, Xia; Lv, Xiaoyang; Luo, Hailing; Wu, Si-Pei; Zou, Chen

doi:10.1016/j.bbrc.2021.06.009

Cited by 15 publications

(8 citation statements)

References 24 publications

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“…Ai et al. ( 271 ) conducted a TNF-a induced apoptosis experiment in OSCC cells. The results of their study showed that TNF-a could induce apoptosis of OSCC cells, which was enhanced by knockdown of circ_0001461.…”

Section: Circular Rna Biogenesis and Circrnas-mediated Programmed Cel...mentioning

confidence: 99%

“…TLR4, a direct target of miR-145, served as the key mediator of circ_0001461 function by promoting the resistance of immune induced apoptosis of OSCC cells. Together, their results suggested that circ_0001461 might promote OSCC cells to resist TNF-a induced apoptosis through TLR4 mediated NF-kB pathway ( 271 ).…”

Section: Circular Rna Biogenesis and Circrnas-mediated Programmed Cel...mentioning

confidence: 99%

“…It has been reported that TLR4 can mediate the immune escape of tumor cells and promote tumor cell to resist druginduced apoptosis (270). Ai et al (271) conducted a TNF-a induced apoptosis experiment in OSCC cells. The results of their study showed that TNF-a could induce apoptosis of OSCC cells, which was enhanced by knockdown of circ_0001461.…”

Section: Inhibition Of Apoptosismentioning

confidence: 99%

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Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

2022

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Oral cancer remains a major public concern with considerable socioeconomic impact in the world. Despite substantial advancements have been made in treating oral cancer, the five-year survival rate for oral cancer remained undesirable, and the molecular mechanisms underlying OSCC carcinogenesis have not been fully understood. Noncoding RNAs (ncRNAs) include transfer RNAs (tRNAs), as well as small RNAs such as microRNAs, and the long ncRNAs such as HOTAIR are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including cancer cell development. Cell death, such as apoptosis, necrosis, and autophagy, plays a vital role in the progression of cancer. A better understanding of the regulatory relationships between ncRNAs and these various types of cancer cell death is therefore urgently required. The occurrence and development of oral cancer can be controlled by increasing or decreasing the expression of ncRNAs, a method which confers broad prospects for oral cancer treatment. Therefore, it is urgent for us to understand the influence of ncRNAs on the development of different modes of oral tumor death, and to evaluate whether ncRNAs have the potential to be used as biological targets for inducing cell death and recurrence of chemotherapy. The purpose of this review is to describe the impact of ncRNAs on cell apoptosis and autophagy in oral cancer in order to explore potential targets for oral cancer therapy.

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Section: Circular Rna Biogenesis and Circrnas-mediated Programmed Cel...mentioning

confidence: 99%

Section: Circular Rna Biogenesis and Circrnas-mediated Programmed Cel...mentioning

confidence: 99%

Section: Inhibition Of Apoptosismentioning

confidence: 99%

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Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

2022

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“…Thus, circRNA-SORE contributed to stabilization of YBX1 protein. Notably, circRNAs also play an important role in the OSCC [ 176 , 177 , 178 , 179 , 180 , 181 ] and circ_0000140 was downregulated in OSCC [ 176 ]. Furthermore, circ_0000140 acts as a sponge for miR-31, then, upregulates its target gene LATS2, which is associated with EMT.…”

Section: Other Ncrnas: Circrnas and Pirnas In Drug Resistancementioning

confidence: 99%

“…Significantly, circIGHG/miR-142-5p/IGF2BP3 axis, and circEPSTI1/mir-942-5p/LTBP2 axis, circUHRF1/miR-526b-5p/c-Myc/TGF-β1/ESRP1 axis were also shown to promote EMT [ 177 , 178 , 179 ]. Furthermore, circ_0001461/miR-145/TLR4/NF-kB axis promotes the resistance of TNF-a-induced apoptosis [ 181 ].…”

Section: Other Ncrnas: Circrnas and Pirnas In Drug Resistancementioning

confidence: 99%

Impact of Non-Coding RNAs on Chemotherapeutic Resistance in Oral Cancer

et al. 2022

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Drug resistance in oral cancer is one of the major problems in oral cancer therapy because therapeutic failure directly results in tumor recurrence and eventually in metastasis. Accumulating evidence has demonstrated the involvement of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in processes related to the development of drug resistance. A number of studies have shown that ncRNAs modulate gene expression at the transcriptional or translational level and regulate biological processes, such as epithelial-to-mesenchymal transition, apoptosis, DNA repair and drug efflux, which are tightly associated with drug resistance acquisition in many types of cancer. Interestingly, these ncRNAs are commonly detected in extracellular vesicles (EVs) and are known to be delivered into surrounding cells. This intercellular communication via EVs is currently considered to be important for acquired drug resistance. Here, we review the recent advances in the study of drug resistance in oral cancer by mainly focusing on the function of ncRNAs, since an increasing number of studies have suggested that ncRNAs could be therapeutic targets as well as biomarkers for cancer diagnosis.

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Knockdown of circGOLPH3 inhibits cell progression and glycolysis by targeting miR‐145‐5p/lysine demethylase 2A (KDM2A) axis in oral squamous cell carcinoma

et al. 2022

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Background Oral squamous cell carcinoma (OSCC) is one of the most common head and neck malignancies. The aim of this study is to explore the role of circRNA Golgi phosphoprotein 3 (GOLPH3) (circGOLPH3) in OSCC. Methods Quantitative real‐time polymerase chain reaction (qRT‐PCR) and western blot were performed to detect changes in the levels of circGOLPH3, microRNA‐145‐5p (miR‐145‐5p), and lysine demethylase 2A (KDM2A). The functions of circGOLPH3 were assessed using in vitro and in vivo assays. Dual‐luciferase reporter assay detected the interaction of miR‐145‐5p with circGOLPH3 or KDM2A. Results circGOLPH3 expression was upregulated in OSCC. circGOLPH3 downregulation inhibited cell growth, metastasis, and glycolysis in vitro, and in vivo experiments revealed that circGOLPH3 inhibited tumor growth. In addition, circGOLPH3 bound to miR‐145‐5p and competitively inhibited KDM2A expression, thereby regulating OSCC cell behaviors as well as glycolysis. Conclusion circGOLPH3 exerted pro‐oncogenic effects through the miR‐145‐5p/KDM2A axis to regulate OSCC cell behaviors.

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circ_0001461 promotes oral squamous cell carcinoma progression through miR-145/TLR4/NF-κB axis

Cited by 15 publications

References 24 publications

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

Impact of Non-Coding RNAs on Chemotherapeutic Resistance in Oral Cancer

Knockdown of circGOLPH3 inhibits cell progression and glycolysis by targeting miR‐145‐5p/lysine demethylase 2A (KDM2A) axis in oral squamous cell carcinoma

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