circ-PSD3 promoted proliferation and invasion of papillary thyroid cancer cells via regulating the miR-7-5p/METTL7B axis

Zhu, Jian Jun; Wang, Yongbin; Yang, Chuanzhou; Feng, Zhiping; Huang, Yanni; Liu, Pengjie; Chen, Fukun; Deng, Zhong‐Liang

doi:10.1080/10799893.2021.1910706

Cited by 10 publications

(8 citation statements)

References 41 publications

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“…Several studies investigating TMT1B’s effects have highlighted a role in the regulation of cell proliferation in cancer cells. Following the loss of TMT1B expression in thyroid cancer cells, a significant decrease in proliferation was found, similar to effects seen in non-small cell lung cancer, clear cell renal cancer, and glioma cells ( 4 , 21 – 23 , 26 – 29 , 32 , 33 , 50 ). Conversely, overexpression of TMT1B in thyroid cancer and lung adenocarcinoma cells significantly promoted cell proliferation ( 29 , 50 ).…”

Section: Functional Role Of Tmt1b In Cancersupporting

confidence: 66%

Defining the elusive oncogenic role of the methyltransferase TMT1B

Denford

Wilhelm

2023

Front. Oncol.

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Methyltransferases are enzymes fundamental to a wide range of normal biological activities that can become dysregulated during oncogenesis. For instance, the recent description of the methyltransferase-like (METTL) family of enzymes, has demonstrated the importance of the N6-adenosine-methyltransferase (m6A) modification in transcripts in the context of malignant transformation. Because of their importance, numerous METTL family members have been biochemically characterized to identify their cellular substrates, however some members such as METTL7B, recently renamed TMT1B and which is the subject of this review, remain enigmatic. First identified in the stacked Golgi, TMT1B is also localized to the endoplasmic reticulum as well as lipid droplets and has been reported as being upregulated in a wide range of cancer types including lung cancer, gliomas, and leukemia. Interestingly, despite evidence that TMT1B might act on protein substrates, it has also been shown to act on small molecule alkyl thiol substrates such as hydrogen sulfide, and its loss has been found to affect cellular proliferation and migration. Here we review the current evidence for TMT1B’s activity, localization, and potential biological role in the context of both normal and cancerous cell types.

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Section: Functional Role Of Tmt1b In Cancersupporting

confidence: 66%

Defining the elusive oncogenic role of the methyltransferase TMT1B

Denford

Wilhelm

2023

Front. Oncol.

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“…Another PSD3-derived circRNA was found to be significantly upregulated in papillary thyroid cancer tissues and cell lines and was positively associated with a larger tumor size, TNM stage, and lymph node metastasis. circPSD3 knockdown suppressed papillary thyroid cancer cell proliferation and invasion by enhancing the inhibitory effect of miR-7-5p on the expression of METTL7B [ 48 ]. The pathological functions of different PSD3-derived circRNAs have also been investigated in hepatic fibrosis [ 49 ] and hepatitis C virus (HCV) infection [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

circPSD3 is a promising inhibitor of uPA system to inhibit vascular invasion and metastasis in hepatocellular carcinoma

Xu,

Wang,

et al. 2023

Mol Cancer

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Background Vascular invasion is a major route for intrahepatic and distant metastasis in hepatocellular carcinoma (HCC) and is a strong negative prognostic factor. Circular RNAs (circRNAs) play important roles in tumorigenesis and metastasis. However, the regulatory functions and underlying mechanisms of circRNAs in the development of vascular invasion in HCC are largely unknown. Methods High throughput sequencing was used to screen dysregulated circRNAs in portal vein tumor thrombosis (PVTT) tissues. The biological functions of candidate circRNAs in the migration, vascular invasion, and metastasis of HCC cells were examined in vitro and in vivo. To explore the underlying mechanisms, RNA sequencing, MS2-tagged RNA affinity purification, mass spectrometry, and RNA immunoprecipitation assays were performed. Results circRNA sequencing followed by quantitative real-time PCR (qRT-PCR) revealed that circRNA pleckstrin and Sect. 7 domain containing 3 (circPSD3) was significantly downregulated in PVTT tissues. Decreased circPSD3 expression in HCC tissues was associated with unfavourable characteristics and predicted poor prognosis in HCC. TAR DNA-binding protein 43 (TDP43) inhibited the biogenesis of circPSD3 by interacting with the downstream intron of pre-PSD3. circPSD3 inhibited the intrahepatic vascular invasion and metastasis of HCC cells in vitro and in vivo. Serpin family B member 2 (SERPINB2), an endogenous bona fide inhibitor of the urokinase-type plasminogen activator (uPA) system, is the downstream target of circPSD3. Mechanistically, circPSD3 interacts with histone deacetylase 1 (HDAC1) to sequester it in the cytoplasm, attenuating the inhibitory effect of HDAC1 on the transcription of SERPINB2. In vitro and in vivo studies demonstrated that circPSD3 is a promising inhibitor of the uPA system. Conclusions circPSD3 is an essential regulator of vascular invasion and metastasis in HCC and may serve as a prognostic biomarker and therapeutic target.

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“…To date, numerous circRNAs have been proposed to bind to various miRNAs and inhibit their mRNA activity via a function known as miRNA spongs or decoys (Supplementary Materials S1,2). Studies suggested that identical circRNAs contain multiple miRNA-binding sites that can perform various functions by sponging different miRNAs and inhibiting their mRNA activity (Qi et al, 2021b), as exemplified by circPSD3, which contains target sites for miR-7-5p, miR-885-5p and miR-637 (Jin et al, 2018;Li et al, 2021e;Zhu et al, 2021). Studies have also revealed that different circRNAs contain the same type and miRNA binding sites that can specifically bind to miRNAs, thereby reducing miRNA activity and upregulating the expression of miRNA-related target genes (Shu et al, 2020;Luo et al, 2021), such as hsa_circ_0058124 and circUBAP2, which are revealed as miR-370-3p sponges and promote proliferation and invasion of TC cells (Liu L. et al, 2020;Xiong et al, 2021b).…”

Section: Biological Functions Of Circrnas In Tc Oncogenic Activity Of...mentioning

confidence: 99%

“…Compared with normal controls, circRNAs present significantly differential expression profiles in TC tissues and blood from patients with TC; thus, they are regarded as promising and ideal candidates for the diagnosis of TC owing to their abnormal expression and high specificity (Table 2; Figure 4) (Jin et al, 2018;Lan et al 2018a;Ren et al 2018;Wang et al 2018b;Wei et al 2018;Cai et al 2019;Yao et al 2019;Wang et al 2019a;Fan et al 2020;Han et al 2020a;Hu et al 2020b;Liu et al 2020b;Sun et al 2020b;Wang et al 2020b;Wu et al 2020a;Xue et al 2020;Ye et al, 2020;Yu et al, 2020;Zhang et al 2020b;Chu et al, 2021;Ding et al 2021a;Ding et al 2021b;Du et al 2021;Guo et al 2021;Li et al 2021a;Li et al 2021b;Li et al 2021d;Lin et al 2021;Liu et al 2021b;Luo et al, 2021;Ma and Kan, 2021;Qi et al, 2021b;Xiong et al, 2021b;Zeng et al, 2021;Zhang et al 2021c;Zhang et al 2021d;Zheng et al 2021a;Zhu et al, 2021;…”

Section: Circrnas As Promising Diagnostic and Prognostic Biomarkers F...mentioning

confidence: 99%

Function and Clinical Significance of Circular RNAs in Thyroid Cancer

Yao

Zhang²

2022

Front. Mol. Biosci.

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Thyroid cancer (TC) is the leading cause and mortality of endocrine malignancies worldwide. Tumourigenesis involves multiple molecules including circular RNAs (circRNAs). circRNAs with covalently closed single-stranded structures have been identified as a type of regulatory RNA because of their high stability, abundance, and tissue/developmental stage-specific expression. Accumulating evidence has demonstrated that various circRNAs are aberrantly expressed in thyroid tissues, cells, exosomes, and body fluids in patients with TC. CircRNAs have been identified as either oncogenic or tumour suppressor roles in regulating tumourigenesis, tumour metabolism, metastasis, ferroptosis, and chemoradiation resistance in TC. Importantly, circRNAs exert pivotal effects on TC through various mechanisms, including acting as miRNA sponges or decoys, interacting with RNA-binding proteins, and translating functional peptides. Recent studies have suggested that many different circRNAs are associated with certain clinicopathological features, implying that the altered expression of circRNAs may be characteristic of TC. The purpose of this review is to provide an overview of recent advances on the dysregulation, functions, molecular mechanisms and potential clinical applications of circRNAs in TC. This review also aimes to improve our understanding of the functions of circRNAs in the initiation and progression of cancer, and to discuss the future perspectives on strategies targeting circRNAs in TC.

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circ-PSD3 promoted proliferation and invasion of papillary thyroid cancer cells via regulating the miR-7-5p/METTL7B axis

Cited by 10 publications

References 41 publications

Defining the elusive oncogenic role of the methyltransferase TMT1B

Defining the elusive oncogenic role of the methyltransferase TMT1B

circPSD3 is a promising inhibitor of uPA system to inhibit vascular invasion and metastasis in hepatocellular carcinoma

Function and Clinical Significance of Circular RNAs in Thyroid Cancer

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