Circ
            <i>TTLL13</i>
            Promotes TMZ Resistance in Glioma via Modulating
            <i>OLR1</i>
            -Mediated Activation of the Wnt/β-Catenin Pathway

Li, Jun; Ma, Junfeng; Huang, Shan; Li, Jun; Zhou, Liang; Sun, Jiahua; Lin, Chen

doi:10.1080/10985549.2023.2210032

Cited by 6 publications

(2 citation statements)

References 39 publications

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“…Shi et al reported that METTL3 methylation is elevated in glioblastoma tissues resistant to temozolomide (TMZ), with METTL3 overexpression increasing the stability of DNA repair enzymes, suggesting a mechanism for TMZ resistance [ 118 ]. Additionally, it has been shown that METTL3-mediated methylation indirectly fosters TMZ resistance by stabilizing Oxidized Low-Density Lipoprotein Receptor 1 (OLR1), a receptor involved in lipid metabolism and cellular signaling, and by activating the Wnt/β-Catenin pathway [ 119 ].…”

Section: Rna Modifications In Gliomamentioning

confidence: 99%

“…YTHDF1 is involved in various mechanisms that contribute to glioma resistance and progression. For instance, it stabilizes OLR1 mRNA, influencing the OLR1-mediated Wnt/β-Catenin pathway activation, which is linked to TMZ resistance in glioma [ 119 ]. Additionally, YTHDF1 plays a role in RNA editing, as it binds and promotes the translation of m6A-modified ADAR1, a molecule implicated in glioma progression [ 164 ].…”

Section: Rna Modifications In Gliomamentioning

confidence: 99%

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Emerging Roles and Mechanisms of RNA Modifications in Neurodegenerative Diseases and Glioma

Kobayashi,

Kitagawa,

Nasser

et al. 2024

Cells

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Despite a long history of research, neurodegenerative diseases and malignant brain tumor gliomas are both considered incurable, facing challenges in the development of treatments. Recent evidence suggests that RNA modifications, previously considered as static components of intracellular RNAs, are in fact dynamically regulated across various RNA species in cells and play a critical role in major biological processes in the nervous system. Innovations in next-generation sequencing have enabled the accurate detection of modifications on bases and sugars within various RNA molecules. These RNA modifications influence the stability and transportation of RNA, and crucially affect its translation. This review delves into existing knowledge on RNA modifications to offer a comprehensive inventory of these modifications across different RNA species. The detailed regulatory functions and roles of RNA modifications within the nervous system are discussed with a focus on neurodegenerative diseases and gliomas. This article presents a comprehensive overview of the fundamental mechanisms and emerging roles of RNA modifications in these diseases, which can facilitate the creation of innovative diagnostics and therapeutics for these conditions.

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Section: Rna Modifications In Gliomamentioning

confidence: 99%

Section: Rna Modifications In Gliomamentioning

confidence: 99%

Emerging Roles and Mechanisms of RNA Modifications in Neurodegenerative Diseases and Glioma

Kobayashi,

Kitagawa,

Nasser

et al. 2024

Cells

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CircVCAN promotes glioma progression through the miR‐488‐3p/MEF2C‐JAGGED1 axis

Yang,

Gao,

Dong

2024

Environmental Toxicology

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Gliomas are the most prevalent primary malignant brain tumors worldwide. Growing evidences indicate that circular RNAs (circRNAs) play an important role in the regulation of biological behavior of tumors. We aimed to investigate the role and mechanism of circVCAN in glioma. RNase R treatment was utilized to assess the cyclic properties of circVCAN. CircVCAN, miR‐488‐3p, and myocyte enhancer factor 2C (MEF2C) levels in glioma tissues and cells were detected by reverse transcription real‐time polymerase chain reaction (RT‐qPCR), and the localization of them in glioma cells was determined with fluorescence in situ hybridization. Furthermore, a variety of biologically functional assessments were used to validate the role of circVCAN in glioma. The regulatory mechanisms of circVCAN, miR‐488‐3p, and MEF2C were further confirmed by double luciferase reporter gene assay, RNA immunoprecipitation and RNA pull‐down assay, and the binding of MEF2C to JAGGED1 was revealed by chromatin immunoprecipitation. Additionally, a xenograft tumor model was constructed to demonstrate the effect of circVCAN on tumor growth in vivo. Our results indicated that circVCAN was more stable than its linear RNA and was significantly upregulated in gliomas. CircVCAN overexpression stimulated glioma cells to proliferate and metastasize, but circVCAN silencing exerted the opposite effect. Meanwhile, silencing circVCAN inhibited tumor growth in vivo. Moreover, we found that circVCAN interacted with miR‐488‐3p to regulate MEF2C expression, and miR‐488‐3p inhibition or MEF2C overexpression reversed the inhibitory effect on malignant bio‐behaviors mediated by circVCAN knockdown in glioma cells. MEF2C promoted the transcription of JAGGED1, and circVCAN knockdown reduced the binding between MEF2C and JAGGED1. Collectively, circVCAN is a carcinogenic circRNA in glioma, and the circVCAN/miR‐488‐3p/MEF2C‐JAGGED1 axis could serve as a potential target for the management of glioma.

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Analysis of differentially expressed genes in dysplastic oral keratinocyte cell line and their role in the development of HNSCC

BS,

et al. 2024

Journal of Stomatology, Oral and Maxillofacial Surgery

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Circ TTLL13 Promotes TMZ Resistance in Glioma via Modulating OLR1 -Mediated Activation of the Wnt/β-Catenin Pathway

Cited by 6 publications

References 39 publications

Emerging Roles and Mechanisms of RNA Modifications in Neurodegenerative Diseases and Glioma

Emerging Roles and Mechanisms of RNA Modifications in Neurodegenerative Diseases and Glioma

CircVCAN promotes glioma progression through the miR‐488‐3p/MEF2C‐JAGGED1 axis

Analysis of differentially expressed genes in dysplastic oral keratinocyte cell line and their role in the development of HNSCC

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