circ-0007707/miR-429/PDGFD Pathway Regulates the Progression of Gastric Cancer by Modulating the Immune-Gene Signature

Yang, Yang; Kang, Weibiao; Yuan, Yu; Duan, Chen; Chen, Wei; Yu, Changjun

doi:10.1155/2022/2214686

Cited by 6 publications

(6 citation statements)

References 29 publications

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“…No association between these 10 genes and acne has been reported before. In gastric cancer, PDGFD regulates the immune microenvironment by modulating the immune genes TAB1 and CXCR4 , while lipopolysaccharide (LPS) induced inflammation is mediated by CXCR4 , which binds bacterial LPS [ 28 , 29 ]. Severe acne can cause infiltration of inflammatory cells and severe inflammation response under the irritation of Cutibacterium acnes ( C. acnes ).…”

Section: Discussionmentioning

confidence: 99%

Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis

et al. 2023

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Severe acne is a chronic inflammatory skin condition that is affected by both genetic and environmental factors. DNA methylation is associated with a variety of inflammatory skin diseases, but its role in severe acne is unclear. In this study, we conducted a two-stage epigenome correlation study using 88 blood samples to identify disease-related differential methylation sites. We found close associations between the DNA methylation at 23 differentially methylated sites (DMSs) and severe acne, including PDGFD, ARHGEF10 , etc. Further analysis revealed that differentially methylated genes ( PARP8 and MAPKAPK2 ) were also expressed differently between severe acne and health control groups. These findings lead us to speculation that epigenetic mechanisms may play an important role in the pathogenesis of severe acne.

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Section: Discussionmentioning

confidence: 99%

Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis

et al. 2023

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“…Currently, although a number of circRNAs, functioning as oncogenes or tumor suppressors, have been reported to be involved in STAD progression [ 28 – 31 ], no studies have so far addressed circ_0000182’s role in STAD. Furthermore, there has been a few recent studies presenting that circRNAs have a strong ability to participate in regulating cholesterol metabolism in non-tumor cells, such as macrophages and aortic endothelial cells [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…CeRNA networks based on circRNAs have an impact on the occurrence and development of gastrointestinal cancers [ 40 ]. Furthermore, it has been found that circRNAs acted as ceRNAs for miRNAs to regulate proliferation of STAD cells [ 28 , 31 ]. Interestingly, lncRNA‐TTN‐AS1 was found to act as a ceRNA for miR‐133b to regulate the expression of SQLE in pancreatic cancer cells [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Circ_0000182 promotes cholesterol synthesis and proliferation of stomach adenocarcinoma cells by targeting miR-579-3p/SQLE axis

Qian

Zhou

et al. 2023

Discov Onc

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Background Circular RNAs (circRNAs) or cholesterol metabolism have been demonstrated to participate in stomach adenocarcinoma (STAD) progression. However, the relationship between circRNAs and cholesterol metabolism in STAD and its underlined mechanism remain unclear. Methods RNA and protein expression levels were detected by qRT-PCR and Western blot. Cell proliferation was assessed by CCK-8, EdU incorporation and colony formation assays. Total cholesterol (TC) and free cholesterol (FC) levels were measured by the corresponding kits. The relationships between circ_0000182 and miR-579-3p or squalene epoxidase (SQLE) mRNA were investigated by bioinformatics analysis, RNA-RNA pull-down, luciferase reporter and RIP assays. Results We found that circ_0000182 expression was significantly up-regulated in both STAD tissues and cell lines, and high circ_0000182 expression was correlated with increased tumor size. Circ_0000182 promoted cell proliferation and cholesterol synthesis of STAD cells. Accordingly, cell proliferation, cholesterol synthesis and SQLE expression were significantly inhibited by circ_0000182 knockdown in STAD cells, and these effects were partly reversed by miR-579-3p inhibition or SQLE over-expression. Furthermore, we identified that circ_0000182 acted as a competing endogenous RNA (ceRNA) by sponging miR-579-3p, thereby facilitating SQLE expression, cholesterol synthesis and cell proliferation. Conclusion Circ_0000182 promotes cholesterol synthesis and proliferation of STAD cells by enhancing SQLE expression via sponging miR-579-3p.

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“…In our study, we first identified 36 OSRGs that are associated with STAD prognosis and the functions of these genes in STAD have been gradually elucidated in recent years. For instance, the elevated expression of the platelet-derived growth factor D (PDGFD) was proved to be an indicator for a poor prognostic outcome of patients with gastric cancer (GC) ( 13 ), and the PDGFD-related immune-gene signature was regarded as a moderator to guide immunotherapy programs. Glutathione peroxidase 3 (GPX3) has been confirmed to prevent migration and invasion in GC via NF-κB/Wnt5a/JNK signaling ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

“…Studies have reported that OSRGs are predictive of cancers such as gliomas (9), bladder cancer (10), and prostate cancer (11). The potential role of OSRGs in the tumorigenesis and progression of STAD has been gradually demonstrated by growing evidence (12)(13)(14)(15). Nonetheless, limited knowledge is available about the molecular pattern of OSRGs in STAD and the link of OSRGs with clinical features, immune landscape, and response to immunotherapy, and drug sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Constructing a novel gene signature derived from oxidative stress specific subtypes for predicting survival in stomach adenocarcinoma

Zhou¹,

Peng

2022

Front. Immunol.

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Oxidative stress (OS) response is crucial in oncogenesis and progression of tumor. But the potential prognostic importance of OS-related genes (OSRGs) in stomach adenocarcinoma (STAD) lacked comprehensive study. STAD clinical information and transcriptome data were retrieved from the Gene Expression Omnibus and The Cancer Genome Atlas databases. The prognostic OSRGs were filtered via the univariate Cox analysis and OSRG-based molecular subtypes of STAD were developed using consensus clustering. Weighted gene co-expression network analysis (WGCNA) was subsequently conducted to filter molecular subtype-associated gene modules. The prognosis-related genes were screened via univariate and least absolute shrinkage and selection operator Cox regression analysis were used to construct a prognostic risk signature. Finally, a decision tree model and nomogram were developed by integrating risk signature and clinicopathological characteristics to analyze individual STAD patient’s survival. Four OSRG-based molecular subtypes with significant diversity were developed based on 36 prognostic OSRGs for STAD, and an OSRGs-based subtype-specific risk signature with eight genes for prognostic prediction of STAD was built. Survival analysis revealed a strong prognostic performance of the risk signature exhibited in predicting STAD survival. There were significant differences in mutation patterns, chemotherapy sensitivity, clinicopathological characteristics, response to immunotherapy, biological functions, immune microenvironment, immune cell infiltration among different molecular subtypes and risk groups. The risk score and age were verified as independent risk factors for STAD, and a nomogram integrating risk score and age was established, which showed superior predictive performance for STAD prognosis. We developed an OSRG-based molecular subtype and identified a novel risk signature for prognosis prediction, providing a useful tool to facilitate individual treatment for patients with STAD.

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circ-0007707/miR-429/PDGFD Pathway Regulates the Progression of Gastric Cancer by Modulating the Immune-Gene Signature

Cited by 6 publications

References 29 publications

Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis

Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis

Circ_0000182 promotes cholesterol synthesis and proliferation of stomach adenocarcinoma cells by targeting miR-579-3p/SQLE axis

Constructing a novel gene signature derived from oxidative stress specific subtypes for predicting survival in stomach adenocarcinoma

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