Ciprofloxacin-resistant and extended-spectrum β-lactamase-producing Escherichia coli ST410 strain carrying the mcr-1 gene associated with bloodstream infection

Rocha, Igor Vasconcelos; Andrade, Carlos Alberto das Neves; Campos, Túlio de Lima; Rezende, Antônio Mauro; Leal, Nilma Cintra; Vidal, Cláudia Fernanda de Lacerda; Xavier, Danilo Elias

doi:10.1016/j.ijantimicag.2017.03.001

Cited by 19 publications

(11 citation statements)

References 5 publications

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“…coli from this group has been reported on numerous occasions, for example ST10 from human clinical samples in China [ 21 ], ST744 from human and cattle-associated samples in Europe [ 22 , 23 ], ST167 from human infections in Spain and China [ 24 , 25 ], as well as ST48 from hospital sewage and human clinical samples, in China and Switzerland, respectively [ 26 , 27 ]. Additional worldwide clones previously shown to harbor mcr were also confirmed here, and include ST641 [ 28 ], ST410 [ 29 , 30 ], and ST156 [ 31 , 32 ]. Our screening identified two mcr -harboring ST117 E .…”

Section: Resultssupporting

confidence: 78%

Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program

Wise¹,

Estabrook²,

Sahm³

et al. 2018

PLoS ONE

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A set of 908 clinically derived colistin-resistant Enterobacteriaeae isolates collected worldwide in 2014–2016 were screened for the presence of the plasmid-borne mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 genes. In total 3.2% (29/908) of the collection were positive for mcr, including 27 Escherichia coli, 1 Klebsiella pneumoniae and 1 Enterobacter cloacae. Twenty-four isolates possessed genes from the mcr-1 family, including the original mcr-1 (n = 22), as well as mcr-1.2 (n = 1) and mcr-1.5 (n = 1), which each differ from mcr-1 by encoding single amino acid variations. Genes from the mcr-3 family were found in isolates from Thailand, including mcr-3.1 (n = 3) and mcr-3.2 (n = 1). An E. coli isolated from a patient with a urinary tract infection in Colombia contained the recently discovered mcr-5. The full colistin-resistant collection was tested against a panel of antimicrobial agents with ceftazidime-avibactam and tigecycline exhibiting the highest activity.

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Section: Resultssupporting

confidence: 78%

Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program

Wise¹,

Estabrook²,

Sahm³

et al. 2018

PLoS ONE

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show abstract

“…CPE is a worrisome risk in public health due to the multidrug resistance and the potential for dissemination to multiple sources, including transmission from patient to patient. The mobile colistin resistance gene mcr-1 has been reported in ESBL-producing E. coli ST410 in Brazil ( 24 ) and Germany ( 25 ) but was not observed in our 127 isolates. This demonstrates the potential of ST410 to acquire further resistance determinants, leaving very limited therapeutic agents for treating life-threatening bacterial infections.…”

Section: Discussioncontrasting

confidence: 56%

Escherichia coli Sequence Type 410 Is Causing New International High-Risk Clones

Roer

Overballe‐Petersen

Hansen

et al. 2018

mSphere

186

172

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Extraintestinal pathogenic Escherichia coli (ExPEC) is the main cause of urinary tract infections and septicemia. Significant attention has been given to the ExPEC sequence type ST131, which has been categorized as a “high-risk” clone. High-risk clones are globally distributed clones associated with various antimicrobial resistance determinants, ease of transmission, persistence in hosts, and effective transmission between hosts. The high-risk clones have enhanced pathogenicity and cause severe and/or recurrent infections. We show that clones of the E. coli ST410 lineage persist and/or cause recurrent infections in humans, including bloodstream infections. We found evidence of ST410 being a highly resistant globally distributed lineage, capable of patient-to-patient transmission causing hospital outbreaks. Our analysis suggests that the ST410 lineage should be classified with the potential to cause new high-risk clones. Thus, with the clonal expansion over the past decades and increased antimicrobial resistance to last-resort treatment options, ST410 needs to be monitored prospectively.

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“…ST410, which was assigned to isolate M19441, was defined as a hyperepidemic clone and founder of the widely disseminated clonal complex 23 (CC23) [17]. This clone was also previously found to carry mcr-1 as well as bla CTX-M genes in isolates recovered from a turkey hen meat sample in Germany [18] and from a human blood culture in Brazil [19]. In these two last cases, mcr-1 gene was located on the bacterial chromosome [18] and on an IncX4 plasmid [19].…”

Section: Resultsmentioning

confidence: 99%

Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada

et al. 2017

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We have characterized nine mcr-1-harboring plasmids from clinical Escherichia coli isolates previously described in Argentina and Canada. Three of these plasmids carried a mcr-1-variant called here mcr-1.5. All these E. coli isolates were not clonally related and were recovered in different years and locations. However, their mcr-1-harboring plasmids showed high identity among them and to others characterized in other countries, which strongly suggests that this plasmid-type is playing an important role in spreading this mechanism of resistance to polymyxins.

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Ciprofloxacin-resistant and extended-spectrum β-lactamase-producing Escherichia coli ST410 strain carrying the mcr-1 gene associated with bloodstream infection

Cited by 19 publications

References 5 publications

Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program

Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program

Escherichia coli Sequence Type 410 Is Causing New International High-Risk Clones

Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada

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