Ciprofloxacin loaded vascular prostheses functionalized with poly-methylbeta- cyclodextrin: The importance of in vitro release conditions

Garcia-Fernandez, Maria José; Maton, Mickaël; Benzine, Youcef; Tabary, Nicolas; Jean-Baptiste, Elixène; Gargouri, Myriem; Bria, Marc; Blanchemain, Nicolas; Karrout, Youness

doi:10.1016/j.jddst.2019.101166

Cited by 6 publications

(9 citation statements)

References 49 publications

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“…Trotta et al have reported the good performances and the versatility of their nanosponges [56]. Besides, our team has reported the same properties of our poly(cyclodextrin citrate) toward triclosan [39], ciprofloxacin [40], simvastatin [46], ethoxzolamide [57].…”

Section: Study Of the Interactions Between Ibu And Pcd In Solutionsupporting

confidence: 69%

“…where K f (L/g) is the Freundlich constant and 1 n is the relative adsorption capacity characteristic [40].…”

Section: Ibuprofen Sorption and Isotherms Analysesmentioning

confidence: 99%

“…The most commonly used CDs are α-CD, β-CD and È-CD presenting 6, 7 and 8 glucose units respectively [36]. CDs have a truncated cone-shaped 3D structure; their cavity has a hydrophobic character which allows forming inclusion complexes with a large variety of lipophilic molecules, and works as drug carriers to obtain sustained drug delivery systems [23,[37][38][39][40][41][42][43]. Furthermore, CDs can undergo chemical modifications in order to enhance their solubilizing power.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Microbiological and Drug Release of Silver/Ibuprofen Loaded Wound Dressing Designed for the Treatment of Chronically Infected Painful Wounds

et al. 2021

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This study consisted of developing a dressing loaded with silver (Ag) and ibuprofen (IBU) that provides a dual therapy, antibacterial and antalgic, intended for infected painful wounds. Therefore, non-woven polyethyleneterephtalate (PET) textiles nonwovens were pre-treated by cyclodextrin crosslinked with citric acid by a pad/dry/cure process. Then, textiles were impregnated in silver solution followed by a thermal treatment and were then coated by Layer-by-Layer (L-b-L) deposition of a polyelectrolyte multilayer (PEM) system consisting of anionic water-soluble poly(betacyclodextrin citrate) (PCD) and cationic chitosan. Finally, ibuprofen lysinate (IBU-L) was loaded on the PEM coating. We demonstrated the complexation of IBU with native βCD and PCD by phase solubility diagram and 1H NMR. PEM system allowed complete IBU-L release in 6 h in PBS pH 7.4 batch (USP IV). On the other hand, microbiological tests demonstrated that loaded silver induced bacterial reduction of 4 Log10 against S. aureus and E. coli and tests revealed that ibuprofen lysinate loading did not interfere with the antibacterial properties of the dressing.

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Section: Study Of the Interactions Between Ibu And Pcd In Solutionsupporting

confidence: 69%

“…where K f (L/g) is the Freundlich constant and 1 n is the relative adsorption capacity characteristic [40].…”

Section: Ibuprofen Sorption and Isotherms Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Vitro Microbiological and Drug Release of Silver/Ibuprofen Loaded Wound Dressing Designed for the Treatment of Chronically Infected Painful Wounds

et al. 2021

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“…CDs have a truncated cone-shaped 3D structure. They have a hydrophobic cavity that can form inclusion complexes with a large variety of lipophilic molecules and that can work as a drug carrier in sustained release drug delivery systems [ 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. Promising results have been reported with CHT/CDP/metallic nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study

Agossa

Maton

et al. 2021

Antibiotics

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The aim of our study was to explore the potential value of metallic (Ag, Cu, and Zn) salts, polymer/metallic nanoparticles, and chlorhexidine (CHX) for improving the antimicrobial activity of calcium hydroxide (CH) against E. faecalis and C. albicans, associated with persistent endodontic infections. A first screening was performed by determining minimum inhibitory/bactericidal concentrations (MIC/MBC). Antimicrobial activity of the CH paste mixed with metallic salts, chitosan or cyclodextrin polymer metallic nanoparticles was compared to the antimicrobial activity of CH paste alone and CH + CHX using a time-kill kinetics assay. The effect of the antimicrobials on the rheological and the key mechanical properties were also examined. Copper and zinc were discarded because of their MIC/MBC values and silver because of its kill time curve profile. Except for a slower setting time after 24 h and a higher weight loss after 1 week of incubation, the mechanical behavior of the CH paste was unaffected by the addition of CHX. Polymeric/metallic nanoparticles failed to potentiate the antimicrobial effect of CH. By contrast, CHX increased this effect and thus could help eradicate E. faecalis associated with persistent root canal infections without altering the desired key physical properties of the CH paste.

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“…Garcia-Fernandez et al [ 166 ] developed polyester vascular grafts modified with polymerised M-β-CD and loaded with ciprofloxacin to prevent postoperative infections. The release of ciprofloxacin from the prostheses without poly-M-β-CD was faster than from the M-β-CD functionalised prostheses, regardless of the flow rate, indicating the superiority of poly-M-β-CD in the controlled, sustained release of ciprofloxacin.…”

Section: Modern Drug-delivery Systemsmentioning

confidence: 99%

Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective

Boczar

Michalska

2022

Pharmaceutics

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Cyclodextrins (CDs) are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits linked by α-1,4 glycosidic bonds. The shape of CD molecules is similar to a truncated cone with a hydrophobic inner cavity and a hydrophilic surface, which allows the formation of inclusion complexes with various molecules. This review article summarises over 200 reports published by the end of 2021 that discuss the complexation of CDs with antibiotics and antibacterial agents, including beta-lactams, tetracyclines, quinolones, macrolides, aminoglycosides, glycopeptides, polypeptides, nitroimidazoles, and oxazolidinones. The review focuses on drug-delivery applications such as improving solubility, modifying the drug-release profile, slowing down the degradation of the drug, improving biological membrane permeability, and enhancing antimicrobial activity. In addition to simple drug/CD combinations, ternary systems with additional auxiliary substances have been described, as well as more sophisticated drug-delivery systems including nanosponges, nanofibres, nanoparticles, microparticles, liposomes, hydrogels, and macromolecules. Depending on the desired properties of the drug product, an accelerated or prolonged dissolution profile can be achieved when combining CD with antibiotics or antimicrobial agents.

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Ciprofloxacin loaded vascular prostheses functionalized with poly-methylbeta- cyclodextrin: The importance of in vitro release conditions

Cited by 6 publications

References 49 publications

In Vitro Microbiological and Drug Release of Silver/Ibuprofen Loaded Wound Dressing Designed for the Treatment of Chronically Infected Painful Wounds

In Vitro Microbiological and Drug Release of Silver/Ibuprofen Loaded Wound Dressing Designed for the Treatment of Chronically Infected Painful Wounds

How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study

Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective

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