Ciprofloxacin induced toxic epidermal necrolysis with cholestatic hepatitis: A case report with literature review and revisit to the Naranjo adverse drug reaction probability scale

Abstract

Ciprofloxacin, among the many Fluoroquinolones, has been widely used as a broad‐spectrum antibiotic due to its wide range of action and relatively safe adverse effect profile. However, among the cutaneous adverse drug reactions due to Ciprofloxacin, toxic epidermal necrolysis occurring along with cholestatic hepatitis is a rare one. Here, we present a case of a 22‐year‐old male patient who was diagnosed with toxic epidermal necrolysis with cholestatic hepatitis secondary to Ciprofloxacin. Naranjo adverse drug reaction probability scale was used for the causal association.

Levofloxacin-Induced Toxic Epidermal Necrolysis

“…However, reports of adverse drug reactions (ADR) after taking levofloxacin have been made. These ADRs have included everything from an acute purpuric reaction to idiosyncratic hepatotoxicity to toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), both of which can be fatal [ 4 ].…”