Ciprofloxacin‐induced phototoxicity in an adult cystic fibrosis population

Abstract

The incidence of phototoxicity as a side effect of ciprofloxacin appears to be increased in patients with cystic fibrosis compared to the general population (approximately 2.4%). We used an interview-based questionnaire to determine the incidence of such phototoxic skin reactions in cystic fibrosis patients. Results from 105 respondents revealed the incidence of ciprofloxacin-induced phototoxicity in the adult cystic fibrosis population in Northern Ireland to be 48.4% with only 66% of the patients recalling being given sun care information beforehand. We concluded that the incidence of phototoxicity is increased in patients with cystic fibrosis and that it is important for all to receive good sun care information prior to taking ciprofloxacin given the high risk of developing phototoxic rash.

The frequency of photosensitizing drug dispensings in Austria and Germany: a correlation with their photosensitizing potential based on published literature

“…on patients presenting with drug‐induced skin adverse reactions, photosensitivity was the third commonest cause. In specialized photodiagnostic units, systemic drug‐induced photosensitivity is reported to account for up to 15% of photodermatoses . However, these cases only represent those actually referred for investigation of suspected photosensitivity and as such do not reflect the true incidence …”

“…In specialized photodiagnostic units, systemic drug-induced photosensitivity is reported to account for up to 15% of photodermatoses. [20][21][22][23][24][25] However, these cases only represent those actually referred for investigation of suspected photosensitivity and as such do not reflect the true incidence. 10 Up to the present, a large quantity of drugs has been associated with photosensitivity and this number is increasing constantly.…”

“…Besides acute cutaneous adverse effects, an increasing number of reports also suggest chronic sequelae such as increased photoaging or photocarcinogenesis. 26 While there is overwhelming evidence for the photocarcinogenic effects of psoralens, [25][26][27][28][29][30][31][32] several Table 2 All photosensitizing agents (n = 26) in segment 'X2' of Fig. 3 with the number of reports on photosensitivity in brackets, used as indicator of the photosensitizing potential Furosemide (22) Amiodarone (48) Naproxen (24) Vandetanib (15) Ketoprofen (43) Lomefloxacin (41) Tiaprofenic acid (16) Enoxacin (20) Piroxicam (48) Ciprofloxacin (32) Methotrexate (18) Tetracycline (30) Vemurafenib (68) Demeclocycline (33) Dabrafenib (21) Doxycycline (50) Griseofulvin (32) Quinine (27) Voriconazole (38) Hypericin (18) Promethazine (26) Cevimeline (40) Fenofibrate (23) 8-Methoxypsoralen (31) Porfimer (59) Pirfenidone (23) other phototoxic drugs have been associated with photocarcinogenesis.…”

“…Besides acute cutaneous adverse effects, an increasing number of reports also suggest chronic sequelae such as increased photoaging or photocarcinogenesis . While there is overwhelming evidence for the photocarcinogenic effects of psoralens, several other phototoxic drugs have been associated with photocarcinogenesis . This includes fluoroquinolones such as ciprofloxacin or lomefloxacin, NSAIDs, thiazide diuretics, amiloride, amiodarone, tetracyclines, azathioprine, vemurafenib or voriconazole .…”

Ciprofloxacin Photosensitized Oxidation of 2′‐Deoxyguanosine‐5′‐Monophosphate in Neutral Aqueous Solution

“…observed that the maximum transient absorption at 610 nm is the 3 CPX * (30). Evidence has shown that CPX can efficiently cause damage to DNA in vivo (6,7), which may be due to the formation of reactive oxygen species (ROS) such as O 2 · , 1 O 2 , · OH and H 2 O 2 (8,31,32).…”