Ciprofloxacin for Treatment of Tularemia

Johansson, Anders; Berglund, Lennart; Sjöstedt, Anders; Tärnvik, Arne

doi:10.1086/321825

Cited by 62 publications

(33 citation statements)

References 8 publications

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“…Alt tür holarctica infeksiyonu geçiren dört olguda oral siprofloksasin (1500 mg/gün) ve bir olguda norfloksasin (800 mg/gün) kullanılmış ve komplikasyonsuz iyileşme gözlenmiştir (37). İsveç'te 43 tularemi olgusuna 10 gün süreyle oral siprofloksasin verilmiş ve 41'inde (24 ülseroglandülar, 3 pulmoner ve 14 tifoidal tularemili) mükem-mel yanıt alınmıştır (tedavi başarı oranı %95) (39). Kuzeybatı İspanya'da 142 (87'si ülseroglandüler, 29'u tifoidal, 13'ü glandüler, altısı oküloglandüler, beşi pnömonik ve ikisi faringeal) olgunun tanımlandığı bir salgında siprofloksasin, streptomisin ve doksisiklinin tedavi etkinlikleri karşılaştırılmıştır.…”

Section: Kinolonlarunclassified

“…Genel olarak; (a) ateşin varlığı veya devamlılığı ve/veya (b) lenfadenopatinin büyüklüğünde artış veya yeni lenfadenopatilerin gelişmesi ya da (c) konstitüsyonel belirtilerin devamlılığı ile birlikte akut faz reaktanlarının yüksekliği, tedavi başarısızlığı olarak kabul edilmektedir (4,7,10,14,17,39,40).…”

Section: Tularemi Tedavisinde Klinik Ve Maliyet Etkinlik Ile Uluslaraunclassified

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Tularemia: A General Overview on Current Treatment Options

Kılıç¹,

Yeşilyurt²

2011

Klimik Dergisi

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ÖzetTularemi, Francisella tularensis'in etken olduğu, dünya çapında bir dağılım gösteren ve farklı klinik belirtilerle seyreden zoonotik bir infeksiyon hastalığıdır. İnsanlarda klinik tablo lokalize hastalıktan fülminan, yaşamı tehdit eden pnömoni veya septisemiye kadar değişmektedir. Tularemi tedavisinde yıllardır streptomisin, gentamisin ve tetrasiklin kullanılmaktadır, ancak son zamanlarda kinolonlar önemli bir alternatif olarak kabul edilmektedir. AbstractTularemia is a zoonotic infection caused by Francisella tularensis with a worldwide distribution and diverse clinical manifestations. In humans, the disease varies from a localized illness to fulminant, life-threatening pneumonia or septicemia. For decades, streptomycin, gentamicin, and tetracycline have been used for the treatment of tularemia, but more recently, quinolones have been considered as acceptable alternatives. However, there are no randomized trials supporting the use of these antibiotics compared with each other. The increasing number of tularemia outbreaks in regions of Turkey outside the classic endemic areas in recent years has prompted renewed interest in this infectious disease. In this review, suggestions about treatment of tularemia are presented in the light of current literature. Klimik Dergisi 2011; 24(1): 2-10.

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Section: Kinolonlarunclassified

Section: Tularemi Tedavisinde Klinik Ve Maliyet Etkinlik Ile Uluslaraunclassified

Tularemia: A General Overview on Current Treatment Options

Kılıç¹,

Yeşilyurt²

2011

Klimik Dergisi

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“…Streptomycin, gentamicin, doxycycline, and quinolones are currently used in the treatment of tularemia [27,28]. Since F. tularensis is intrinsically resistant to beta-lactam antibiotics, this group of antibiotics is not used in treatment.…”

Section: Discussionmentioning

confidence: 99%

Oropharyngeal tularemia cases admitted to a military hospital in Ankara, Turkey

Karakaş

Çoşkun

Artuk

et al. 2014

J Infect Dev Ctries

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Introduction: This study aimed to review the possible sources of infection of 16 oropharyngeal tularemia hospital cases, and to document their epidemiological and demographical characteristics, laboratory findings, treatment methods, and treatment results. Methodology: Sixteen cases from a Turkish military hospital between January 2011 and December 2012 were retrospectively evaluated. The age, sex, occupation, place of residence, symptoms, duration of symptoms, laboratory results, treatment and duration, and treatment results were recorded. Tularemia was diagnosed through tularemia-specific tests once the other conditions that may have caused lymphadenopathy were excluded. Results: Twelve of the patients included in this study were males. The average age of the patients was 32.1±17.2 years. Sore throat, fatigue, and fever were the most frequent symptoms. The mean duration of symptoms was 21.6±6.9 days. All the patients had been treated for tonsillopharyngitis in primary healthcare institutions previously. However, despite the treatment, cervical lymphadenopathy had developed in these cases. Patients were given streptomycin, doxycycline, and ciprofloxacin monotherapy or in combination. Ten of the cases fully recovered, while five required surgical lymph node drainage. Spontaneous drainage occurred in the single remaining case. Conclusions: Turkey is considered to be an endemic country with regards to tularemia. Prompt diagnosis and proper treatment of the disease is imperative in providing cure. Since it can be potentially confused with tuberculous lymphadenitis, differential diagnosis is vital. Patients presenting with a condition of tonsillopharyngitis in endemic areas must be carefully monitored.

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“…The first clinical reports from Scandinavia exhibited excellent response among both children and adults with tularemia [28,29]. Perez-Castrillon et al [13] have revealed that the efficacy of ciprofloxacin was higher than that of streptomycin or doxycycline and was associated with fewer adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Tularemia in Bulgaria 2003-2004

Komitova

Nenova

Padeshki

et al. 2010

J Infect Dev Ctries

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Introduction: Tularemia is an uncommon but potentially fatal zoonosis. А second outbreak of tularemia in Bulgaria, about 40 years after the first, occurred in 1997 in two western regions, near the Serbian border. In 2003 tularemia reemerged in the same foci. This retrospective study aimed to evaluate the clinical characteristics and the efficacy of antibiotic therapy in a tularemia resurgence in the Slivnitza region in [2003][2004]. Methodology: A total of 26 cases were evaluated. Using medical records, the following data were collected for all patients: symptoms, physical signs, and microbiology results of agglutination tests, cultures and PCR assays. Results: Twenty-four of 26 suspected tularemia patients were laboratory confirmed by agglutination test and/or culture. Fifteen (57.7%) patients had clinical presentation compatible with oropharyngeal, 8 (30.8%) with glandular, and 3 (11.5%) with oculoglandular tularemia. The most frequent symptoms were swollen neck (84.6%) and sore throat (76.9%). Lymphadenopathy (100%) was the most common finding. Francisella tularensis (F. tularensis) was detected by PCR, providing a definitive diagnosis in 82.3% of the cases. All the patients were treated with antibiotics considered effective against F. tularensis; however, therapeutic failure was observed in 23.1% of the cases, which was related to a delay in the initiation of antibiotics. Conclusion: The tularemia outbreak in west Bulgaria near the Serbian border was probably food-borne, associated with a surge in the rodent population. The oropharyngeal form was the most common. Although the disease runs a benign course, late initiation of antimicrobial therapy might delay complete recovery.

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Ciprofloxacin for Treatment of Tularemia

Cited by 62 publications

References 8 publications

Tularemia: A General Overview on Current Treatment Options

Tularemia: A General Overview on Current Treatment Options

Oropharyngeal tularemia cases admitted to a military hospital in Ankara, Turkey

Tularemia in Bulgaria 2003-2004

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