Ciprofloxacin Decreased Polyoma BK Virus Load in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation

Leung, Anskar Y. H.; Chan, May K.M.; Yuen, Kwok‐Yung; Cheng, Vincent Chi-Chung; Chan, Konan; Wong, Chris L. P.; Liang, Raymond; Lie, Albert K. W.; Kwong, Yok–Lam

doi:10.1086/427291

Cited by 205 publications

(173 citation statements)

References 23 publications

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“…8,15,17,19,20,[26][27][28][29] A peak in BK viruria X3 to 6-log correlates with the occurrence of HC. 1,18,29,30 Consistent with these data, all the patients in our study had a BK viruria higher than 10 8 copies/mL indicating that BK viruria may not be the most relevant factor for the prediction of BKV-HC severity. As proposed by Bedi et al and others,17,23,31,32 BKV-HC is a threestep process, in which the last phase corresponds to hematopoietic reconstitution.…”

Section: High Burden Of Bk Virus-associated Hemorrhagic Cystitis L Gisupporting

confidence: 85%

High burden of BK virus-associated hemorrhagic cystitis in patients undergoing allogeneic hematopoietic stem cell transplantation

Gilis

Morisset

Billaud

et al. 2014

Bone Marrow Transplant

120

153

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on behalf of the Lyon BK virus Study group 5 BK virus (BKV) reactivation has been increasingly associated with the occurrence of late-onset hemorrhagic cystitis (HC) after allogeneic hematopoietic SCT (allo-HSCT) resulting in morbidity and sometimes mortality. We investigated the incidence, risk factors and outcome of BKV-HC in 323 consecutive adult patients undergoing allo-HSCT over a 5-year period. BK viremia values for HC staging were evaluated, as well as the medico-economic impact of the complication. Forty-three patients developed BKV-HC. In univariate analysis, young age (P ¼ 0.028), unrelated donor (P ¼ 0.0178), stem cell source (P ¼ 0.0001), HLA mismatching (P ¼ 0.0022) and BU in conditioning regimen (P ¼ 0.01) were associated with a higher risk of developing BKV-HC. In multivariate analysis, patients receiving cord blood units (CBUs) (P ¼ 0.0005) and peripheral blood stem cells (P ¼ 0.011) represented high-risk subgroups for developing BKV-HC. BK viremia was directly correlated to HC severity (P ¼ 0.011) with a 3 to 6-log peak being likely associated with grades 3 or 4 HC. No correlation was found between BKV-HC and acute graft versus host disease or mortality rate. Patients with BKV-HC required a significantly longer duration of hospitalization (Po0.0001), more RBC (P ¼ 0.0003) and platelet transfusions (Po0.0001). Over the 5-year study period, the financial cost of the complication was evaluated at h2 376 076 ($3 088 899). Strategies to prevent the occurrence of late-onset BKV-HC after allo-HSCT are urgently needed, especially in CBU and peripheral blood stem cell recipients. BK viremia correlates with the severity of the disease. Prospective studies are required to test prophylactic approaches.

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Section: High Burden Of Bk Virus-associated Hemorrhagic Cystitis L Gisupporting

confidence: 85%

High burden of BK virus-associated hemorrhagic cystitis in patients undergoing allogeneic hematopoietic stem cell transplantation

Gilis

Morisset

Billaud

et al. 2014

Bone Marrow Transplant

120

153

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“…Several agents have been putatively used in treatment, including ciprofloxacin, intravenous immune globulin, leflunomide and Cidofovir [9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…Quinolones are antibacterial drugs that are DNA gyrase inhibitors. The proposed mechanism of action in BK virus treatment is interference with large T antigen helicase activity for BK virus both in vivo and in vitro [11,12]. IVIG has immunomodulatory properties and has been shown to contain polyomavirus-reactive antibodies [13].…”

Section: Discussionmentioning

confidence: 99%

BK virus-induced acute motor-axonal polyneuropathy in a renal transplant patient

et al. 2015

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Neurological complications are not uncommon in patients with renal transplantation, mostly affecting the central nervous system, and less frequently the peripheral nerves. BK virus infection is relatively common in transplant recipients and in some cases may lead to neurological complications. In this report, we present an interesting case of a patient who developed acute axonal motor polyneuropathy in the course of BK virus infection 3 months after kidney transplantation. After BK virus clearence in blood, a significant improvement was noted in her polyneuropathy. In patients with acute axonal motor polyneuropathy after transplantation BK virus-induced polyneuropathy should be excluded.

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“…There was no response to bladder irrigation, corticosteroids and ciprofloxacin. 6 A week later, his renal function deteriorated, despite cessation of ciclosporin (Figure 1a). A computed tomography scan showed bilateral hydronephrosis and hydroureters at the vesicoureteric junction (Figure 1b), which was confirmed by retrograde pyelogram (Figure 1c).…”

mentioning

confidence: 99%

“…Eight months post HSCT, the patient was asymptomatic with normal renal function, and BKV viraemia and viruria were at levels expected of otherwise asymptomatic HSCT patients. 5,6 The uniqueness of this case is best appreciated by first considering two different patterns of BKV-associated diseases. HC post HSCT is related to uncontrolled uroepithelial BKV replication during the initial immunosuppression post HSCT.…”

mentioning

confidence: 99%

BK virus-associated bilateral ureteric stenosis after haematopoietic SCT: viral kinetics and successful treatment

Hwang

Sim

Leung

et al. 2012

Bone Marrow Transplant

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Ciprofloxacin Decreased Polyoma BK Virus Load in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation

Abstract: Ciprofloxacin decreased urinary BKV reactivation after HSCT.

Cited by 205 publications

References 23 publications

High burden of BK virus-associated hemorrhagic cystitis in patients undergoing allogeneic hematopoietic stem cell transplantation

High burden of BK virus-associated hemorrhagic cystitis in patients undergoing allogeneic hematopoietic stem cell transplantation

BK virus-induced acute motor-axonal polyneuropathy in a renal transplant patient

BK virus-associated bilateral ureteric stenosis after haematopoietic SCT: viral kinetics and successful treatment

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