Ciprofloxacin as a representative of disk diffusion<i>in vitro</i>susceptibility of enrofloxacin for bacterial organisms from the middle‐ear tissue of dogs with end‐stage otitis externa

Cole, Lynette K.; Kwochka, Kenneth W.; Hillier, Andrew; Kowalski, J.; Smeak, Daniel D.; Kelbick, Nicole

doi:10.1111/j.1365-3164.2006.00506.x

Cited by 9 publications

(23 citation statements)

References 6 publications

(20 reference statements)

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“…Almost all of the dogs with chronic OE included in this study had an intact tympanum; only in one dog was the integrity of the tympanum questionable. This is in contrast to another study where the tympanum was ruptured in close to a third of the dogs with chronic OE 5 . Possible reasons for the differing results are different dog populations and breeds on different continents, a longer duration of the OE and the higher proportion of dogs with P. aeroginosa in the latter study 5 …”

Section: Discussioncontrasting

confidence: 70%

“…5 Possible reasons for the differing results are different dog populations and breeds on different continents, a longer duration of the OE and the higher proportion of dogs with P. aeroginosa in the latter study. 5 A significant improvement with treatment was seen cytologically and clinically in all dogs included in this study. This corresponds to other published studies evaluating a variety of ear medications and cleaners.…”

Section: Discussionmentioning

confidence: 71%

“…13,14 Likewise, there are a number of studies describing the in vitro efficacy of several ear medications and cleaners against otic microorganisms. 4,5,[15][16][17][18][19][20][21][22] Very few published clinical studies have evaluated in vivo use of hypochlorous acid for the treatment of canine OE, and none of them focuses on the safety and efficacy of hypochlorous acid as an antiseptic during anesthetised ear flush. [23][24][25] Investigation of in vivo efficacy of antiseptics is warranted as a consequence of increasing multidrug-resistant microorganisms.…”

Section: Introductionmentioning

confidence: 99%

“…While the antimicrobial activities of hypochlorous acid have been evaluated in vitro in a number of studies, few studies have examined in vivo use of hypochlorous acid for skin disease in dogs 13,14 . Likewise, there are a number of studies describing the in vitro efficacy of several ear medications and cleaners against otic microorganisms 4,5,15–22 . Very few published clinical studies have evaluated in vivo use of hypochlorous acid for the treatment of canine OE, and none of them focuses on the safety and efficacy of hypochlorous acid as an antiseptic during anesthetised ear flush 23–25 .…”

Section: Introductionmentioning

confidence: 99%

“…Malassezia pachydermatis is a commonly encountered organism causing ear infections in the dog. 4,5 This commensal organism can proliferate under favourable conditions and contribute to chronic OE. Staphylococcus pseudintermedius is another common organism identified in canine OE.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of hypochlorous acid as an ear flush in dogs with chronic otitis externa

Mueller

Baumann

Boehm

et al. 2022

Veterinary Dermatology

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Background Chronic otitis externa (OE) in dogs frequently requires anaesthetised ear flushing. Objectives To evaluate hypochlorous acid as an ear flushing and antimicrobial agent in dogs with chronic OE. Animals Twenty dogs with chronic OE caused by the same organisms bilaterally. Materials and Methods One ear was flushed under anaesthesia with hypochlorous acid, the other with saline solution. Subsequently, the ear flushed with hypochlorous acid was cleaned with the same solution twice daily for 2 weeks, the other ear with a commercial ear cleaner. An ear medication containing miconazole, polymyxin B and prednisolone was used once daily in both ears. Clinical scores were determined before the flush. Ear cytological results were obtained, a hearing test was conducted before and after the ear flush, and a culture was taken directly after flushing. Ears were evaluated after 2 weeks of therapy. Results Yeast was present in the ears of 11, cocci in one and a mixed infection in eight dogs. Five ears were negative on culture after flushing with hypochlorous acid, one after the saline flush. Clinical and cytological scores decreased significantly with both solutions after 2 weeks of treatment. There was no difference between treatments in any of the scores at any time point between treatments and in the results of the hearing test before and after the flushing procedure. Adverse effects were not seen. Conclusions and Clinical Relevance Hypochlorous acid is a suitable cleaning solution for canine OE.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of hypochlorous acid as an ear flush in dogs with chronic otitis externa

Mueller

Baumann

Boehm

et al. 2022

Veterinary Dermatology

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Effectiveness of chlorhexidine diacetate and povidone‐iodine in antiseptic preparation of the canine external ear canal prior to total ear canal ablation with bulla osteotomy procedure: A preliminary study

Nye

Rogovskyy

Lazarus

et al. 2023

Veterinary Medicine & Sci

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ObjectiveThis article is a preliminary study to compare the ability of 0.05% chlorhexidine diacetate (CD) and 1% povidone‐iodine (PI) solutions to reduce bacterial contamination on the canine external ear canal during initial patient preparation and comparison of the incidence of immediate tissue reactions.Study designThe study is a multi‐institutional, randomised, clinical prospective study.Animals or sample populationDogs (n = 19) undergoing total ear canal ablation with bulla osteotomy (TECABO).MethodsThe external ear of each dog was cleaned with the assigned antiseptic solution. Culture of the ear was performed by standard techniques to semi‐quantitatively evaluate bacterial growth and to identify bacterial organisms pre‐ and post‐antiseptic use.ResultsBoth antiseptic groups showed a significant reduction in bacterial growth score (BGS) between pre‐ and post‐antiseptic use (CD p = 0.009, PI p = 0.005). There was no difference in the reduction of BGS between CD and PI solutions (p = 0.53). Minor adverse skin reactions occurred in 25% of cases. There was no significant difference in the occurrence of adverse skin reactions between antiseptics (p = 0.63).ConclusionCD and PI were similarly able to decrease the number of bacteria on the external ear following initial preparation. No difference in the incidence of adverse tissue reactions was found.Clinical significanceProperly diluted aqueous formulations of either antiseptic may be used for safe preparation limited to the external ear canal of dogs. Additional studies evaluating outcomes such as duration of bacterial inhibition and incidence of surgical site infections are needed to fully elucidate differences between CD and PI antiseptics prior to TECABO.

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Bacterial meningitis secondary to otogenic infection in 10 French bulldogs: A retrospective case series

Butterfield,

Whittaker,

Tabanez

et al. 2023

Veterinary Record Open

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Background There is limited published information to guide the clinical management of bacterial meningitis/encephalitis in dogs. Methods This was a retrospective case series comprising 10 French bulldogs from two referral centres. The cases were diagnosed with bacterial meningitis/encephalitis suspected secondary to otogenic infection based on detection of abnormal fluid/soft tissue opacity within the middle/inner ear, associated meningeal/intracranial involvement through MRI, the findings of cerebro‐spinal fluid (CSF) analysis suggestive of sepsis and/or clinical improvement following antibiosis. Results Ten dogs were included (three female and seven male), with a median age of 60 months. Dogs presented with acute onset (median 2 days), progressive history of vestibular signs and/or intra‐oral or cervical pain. Five dogs had gross signs of concurrent otitis externa. Common MRI findings included material within the tympanic bulla with adjacent meningeal enhancement. Analysis of CSF documented pleocytosis in all eight dogs, intracellular bacteria seen in three with positive bacteriological culture in two dogs. One dog was euthanised following diagnosis. Nine remaining dogs received antimicrobial therapy and six underwent surgical management. Three dogs treated surgically were neurologically normal within 2 weeks and the remaining three improved. Two dogs treated medically improved and one had complete resolution reported within a 4‐week follow‐up period. Study limitations include its retrospective nature and small sample size with minimal longer term follow‐up. Conclusions Bacterial meningitis/encephalitis in French bulldogs can require both medical and surgical treatment to achieve a favourable outcome.

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Ciprofloxacin as a representative of disk diffusionin vitrosusceptibility of enrofloxacin for bacterial organisms from the middle‐ear tissue of dogs with end‐stage otitis externa

Cited by 9 publications

References 6 publications

Evaluation of hypochlorous acid as an ear flush in dogs with chronic otitis externa

Evaluation of hypochlorous acid as an ear flush in dogs with chronic otitis externa

Effectiveness of chlorhexidine diacetate and povidone‐iodine in antiseptic preparation of the canine external ear canal prior to total ear canal ablation with bulla osteotomy procedure: A preliminary study

Bacterial meningitis secondary to otogenic infection in 10 French bulldogs: A retrospective case series

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