Ciprofloxacin Affects Pregnancy Loss in CBA/JxDBA/2J Mice Possibly via Elevation of Interleukin‐3 and Granulocyte Macrophage‐Colony Stimulating Factor Production

Savion, Shoshana; Blank, Miri; Shepshelovich, Jeanne; Fishman, Pnina; Shoenfeld, Yehuda; Toder, V.

doi:10.1111/j.8755-8920.2000.440508.x

Cited by 15 publications

(8 citation statements)

References 17 publications

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“…The resorption rate from the group inoculated with medium containing GM‐CSF was not significantly different to the control. Our results disagreed with previously published data reporting a decrease in the resorption rate after immunization with GM‐CSF 37–39 . The differences in immunization protocols (days of immunization and dose) might be responsible for this discordant findings.…”

Section: Discussioncontrasting

confidence: 99%

Therapy with Dendritic Cells Influences the Spontaneous Resorption Rate in the CBA/J × DBA/2J Mouse Model

Blois

Soto

Olmos

et al. 2004

American J Rep Immunol

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Section: Discussioncontrasting

confidence: 99%

Therapy with Dendritic Cells Influences the Spontaneous Resorption Rate in the CBA/J × DBA/2J Mouse Model

Blois

Soto

Olmos

et al. 2004

American J Rep Immunol

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“…Ciprofloxacin was found to reduce pregnancy loss in an animal model of APS via elevation of Il-3 and GM-CSF production [79][80][81][82]. These in vivo data are complementary to the in vitro studies demonstrating enhanced secretion of CSFs and in vivo studies proving enhanced hematopoiesis in immunocompromised animals.…”

Section: Non-antibacterial Effects Of Fqs In Experimental Animalsmentioning

confidence: 99%

Immunomodulatory Activities of Fluoroquinolones

2005

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A review of published data on the in vitro, ex vivo, in vivo and clinical effects of fluoroquinolones on the synthesis of cytokines is provided. Fluoroquinolones (FQs) were found to affect both cellular and humoral immunity. In general, FQs exert their modulating effects only when used together with a co-stimulant. The in vitro studies generated heterogeneous data because of inhomogeneous effects triggered by different types of co-stimulants and differing responses of various cell lines on the stimuli. However, there is the general trend that FQs decrease the synthesis of pro-inflammatory cytokines. Studies in experimental animals generated homogenous data. All the FQs studied exerted significant clinical effects by attenuating cytokine responses in vivo. The FQs were found to be effective in vivo either in infections caused by organisms against which these are inactive or when dosed suboptimally, so that serum levels were lower than the susceptibilities of the causative pathogens. These in vivo effects were correlated with a significant decrease in pro-inflammatory cytokines like Il-1 and TNF. In addition, FQs were found to upregulate hematopoiesis. These immunomodulatory effects can be attributed in particular to those FQs with a cyclopropyl-moiety at the position N1 of the quinolone core structure, i. e. ciprofloxacin, moxifloxacin, grepafloxacin, sparfloxacin. The immunomodulatory effects of the FQs are due to their effects on intracellular cyclic AMP and phosphodiesterases, on transcription factors such as NF-kappa B, activator protein 1 and a triggering effect on the eucaryotic equivalent of bacterial SOS response. All these studies indicate that FQs exert immunomodulatory activities in particular in latent or chronic infections.

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“…CIP has been included in the Strategic National Stockpile, which is maintained by the U.S. Department of Health and Human Services, to control bacterial infection during a national emergency such as a nuclear detonation or other radiological incident. Besides the antimicrobial activity, several groups reported immunomodulatory effects that CIP exerts in rodent models and human clinical trials [5], [6], improving a wide spectrum of conditions including thrombocytopenia [7], [8], [9], Crohn’s disease [10], [11], rheumatoid arthritis [12], [13] and chemotherapy-induced neutropenia [14]. These favorable improvements are irrelevant to its antimicrobial activity, but rather are ascribed to two general immunomodulatory actions that FQs may share: stimulation of hematopoiesis by enhanced IL-3 and GM-CSF production [15], [16] and reduction of inflammation mediated by IL-1, IL-6, and TNF-α [5].…”

Section: Introductionmentioning

confidence: 99%

Ciprofloxacin Modulates Cytokine/Chemokine Profile in Serum, Improves Bone Marrow Repopulation, and Limits Apoptosis and Autophagy in Ileum after Whole Body Ionizing Irradiation Combined with Skin-Wound Trauma

et al. 2013

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Radiation combined injury (CI) is a radiation injury (RI) combined with other types of injury, which generally leads to greater mortality than RI alone. A spectrum of specific, time-dependent pathophysiological changes is associated with CI. Of these changes, the massive release of pro-inflammatory cytokines, severe hematopoietic and gastrointestinal losses and bacterial sepsis are important treatment targets to improve survival. Ciprofloxacin (CIP) is known to have immunomodulatory effect besides the antimicrobial activity. The present study reports that CIP ameliorated pathophysiological changes unique to CI that later led to major mortality. B6D2F1/J mice received CI on day 0, by RI followed by wound trauma, and were treated with CIP (90 mg/kg p.o., q.d. within 2 h after CI through day 10). At day 10, CIP treatment not only significantly reduced pro-inflammatory cytokine and chemokine concentrations, including interleukin-6 (IL-6) and KC (i.e., IL-8 in human), but it also enhanced IL-3 production compared to vehicle-treated controls. Mice treated with CIP displayed a greater repopulation of bone marrow cells. CIP also limited CI-induced apoptosis and autophagy in ileal villi, systemic bacterial infection, and IgA production. CIP treatment led to LD0/10 compared to LD20/10 for vehicle-treated group after CI. Given the multiple beneficial activities of CIP shown in our experiments, CIP may prove to be a useful therapeutic drug for CI.

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Ciprofloxacin Affects Pregnancy Loss in CBA/JxDBA/2J Mice Possibly via Elevation of Interleukin‐3 and Granulocyte Macrophage‐Colony Stimulating Factor Production

Abstract: Our data demonstrate the ability of ciprofloxacin to reduce pregnancy loss in the CBA/JxDBA/2J mouse model, possibly via elevation of IL-3 and GM-CSF production.

Cited by 15 publications

References 17 publications

Therapy with Dendritic Cells Influences the Spontaneous Resorption Rate in the CBA/J × DBA/2J Mouse Model

Therapy with Dendritic Cells Influences the Spontaneous Resorption Rate in the CBA/J × DBA/2J Mouse Model

Immunomodulatory Activities of Fluoroquinolones

Ciprofloxacin Modulates Cytokine/Chemokine Profile in Serum, Improves Bone Marrow Repopulation, and Limits Apoptosis and Autophagy in Ileum after Whole Body Ionizing Irradiation Combined with Skin-Wound Trauma

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