Cinnamyl Schiff bases: synthesis, cytotoxic effects and antifungal activity of clinical interest

Magalhães, Thaís Furtado Ferreira; Silva, C M da; Santos, Luíza Braga Ferreira dos; Santos, Danielle Anjos dos; Silva, L M; Fuchs, Beth Burgwyn; Mylonakis, Eleftherios; Martins, Cleide Viviane Buzanello; Stoianoff, Maria Aparecida de Resende; Fátima, Ângelo de

doi:10.1111/lam.13356

Cited by 15 publications

(5 citation statements)

References 39 publications

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“…Magalhães et al (2020) [ 64 ] described the synthesis and the in vitro antifungal evaluation of 23 cinnamyl SBs. Six of them showed antifungal activities against strains of Candida , Aspergillus , Fonsecaea and, specifically, Cryptococcus species.…”

Section: Schiff Bases As Antimicrobial Agentsmentioning

confidence: 99%

“…Thus, it was tested against a larger panel of multidrug-resistant C. auris strains (TDG2506, TDG2512, TDG1102, TDG2211, NCPF8984, NCPF8977 and NCPF8971), and its antifungal activity was confirmed with MICs of 4–16 µg/mL, which are very low considering that in four cases (TDG2506, TDG1102, TDG2211 and NCPF8984) the MIC value for fluconazole was ≥128 µg/mL. Compound 41 showed the same results of 40 only on the extended panel [ 64 ].…”

Section: Schiff Bases As Antimicrobial Agentsmentioning

confidence: 99%

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A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies

et al. 2022

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Schiff bases (SBs) have extensive applications in different fields such as analytical, inorganic and organic chemistry. They are used as dyes, catalysts, polymer stabilizers, luminescence chemosensors, catalyzers in the fixation of CO2 biolubricant additives and have been suggested for solar energy applications as well. Further, a wide range of pharmacological and biological applications, such as antimalarial, antiproliferative, analgesic, anti-inflammatory, antiviral, antipyretic, antibacterial and antifungal uses, emphasize the need for SB synthesis. Several SBs conjugated with chitosan have been studied in order to enhance the antibacterial activity of chitosan. Moreover, the use of the nanoparticles of SBs may improve their antimicrobial effects. Herein, we provide an analytical overview of the antibacterial and antifungal properties of SBs and chitosan-based SBs as well as SBs-functionalized nanoparticles. The most relevant and recent literature was reviewed for this purpose.

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Section: Schiff Bases As Antimicrobial Agentsmentioning

confidence: 99%

Section: Schiff Bases As Antimicrobial Agentsmentioning

confidence: 99%

A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies

et al. 2022

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“…Some of the materials reported earlier showed higher antibacterial activity than ciprofloxacin [37]. Antifungal activity of cinnamyl Schiff bases [38] and resistivity of sulphonamides Schiff bases against multidrug-resistant fungi [39] also expose the antimicrobial activity of Schiff base compound.…”

Section: Antimicrobial Studiesmentioning

confidence: 95%

Synthesis of Ferrocene Based Schiff Bases Possessing Different Metal Ion Sensing Aptitude and Partaking Antimicrobial Activity

Dhasarathan

Shunmugaperumal

2022

J. Mex. Chem. Soc.

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Abstract. Schiff bases comprised of highly reactive ferrocene derivatives and normal aromatic moiety have been prepared successfully. Spectral variations noticed in the spectra of newly synthesized receptors for the addition of different metal ions discloses the multi metal ion sensing ability of the prepared sensors. Harmonization of Cu2+ ions with receptor originate as MLCT band in the visible region. Shrewdness made from the data obtained from cyclic voltammetry studies give an idea about the concentration of metal ions needed for effective sensing. In vitro antimicrobial studies and H- bond energy calculation for the interaction between the above sensory materials and proteins of selected microorganisms using molecular docking studies disclosures the antifungal activity of newly prepared materials. Resumen. Bases de Schiff derivadas de grupos ferrocenilos altamente reactivos y grupos aromáticas fueron preparadas exitosamente. La habilidad de los sistemas como sensores para detectar diversos iones metálicos se vió en la variación de las características observadas en sus espectors. La interacción de iones Cu2+ con el receptor produce una banda MLCT en la región visible. Los estudios de voltametría cíclica indican la concentración de los iones metálicos necesaria para una detección eficiente. Estudios antimicrobianos in vitro y cálculos de la energía de puentes de hidrógeno para las interacciones entre los sensores (bases de Schiff) y las proteínas de microorganismos selectos, basados en estudios de acoplamiento molecular, confirman la actividad antifúngica de los nuevos compuestos reportados.

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“…There are reports of high activity in compounds containing an azomethine moiety against multidrug-resistant bacterial strains, e.g., S. aureus (especially methicillin-resistant S. aureus , MRSA) or Staphylococcus epidermidis , including reports of stronger effects than reference drugs such as ciprofloxacin [ 26 , 34 ]. Compounds from the group of Schiff bases also exhibited a higher activity than the reference fluconazole against multidrug-resistant pathogenic fungi classified as Candida [ 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of New Schiff Bases Derived from 4-Amino-5-(3-fluorophenyl)-1,2,4-triazole-3-thione

et al. 2023

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The treatment of infectious diseases is a challenging issue faced by the medical community. The emergence of drug-resistant strains of bacteria and fungi is a major concern. Researchers and medical professionals are working to develop new and innovative treatments for infectious diseases. Schiff bases are one a promising class of compounds. In this work, new derivatives were obtained of the 4-amino-5-(3-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione reaction, with corresponding benzaldehydes with various substituents at position 4. The antibacterial and antifungal activities of all synthesized compounds were tested. Several new substances have shown moderate antifungal activity against Candida spp. The highest activity directed against C. albicans was shown by compound RO4, with a 4-methoxyphenyl moiety and an MIC value of 62.5 µg/mL. In order to check the toxicity of the synthesized compounds, their effect on cell lines was examined. Additionally, we tried to elucidate the mechanism of the antibacterial and antifungal activity of the tested compounds using molecular docking to topoisomerase IV, D-Alanyl-D-Alanine Ligase, and dihydrofolate reductase.

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Cinnamyl Schiff bases: synthesis, cytotoxic effects and antifungal activity of clinical interest

Cited by 15 publications

References 39 publications

A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies

A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies

Synthesis of Ferrocene Based Schiff Bases Possessing Different Metal Ion Sensing Aptitude and Partaking Antimicrobial Activity

Synthesis and Biological Evaluation of New Schiff Bases Derived from 4-Amino-5-(3-fluorophenyl)-1,2,4-triazole-3-thione

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