Cinnamon modulates the pharmacodynamic &amp; pharmacokinetic of amlodipine in hypertensive rats

Abdelrahman, Ibrahim Abdelsalam; Ahad, Abdul; Raish, Mohammad; Jardan, Yousef A. Bin; Alam, Mohammad Mumtaz; Al-Jenoobi, Fahad I.

doi:10.1016/j.jsps.2023.101737

Cited by 4 publications

(2 citation statements)

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“…For 2 weeks, the 3rd and 4th groups of rats were administered L-NAME + cumin (200 mg/kg) [21,32,33] and L-NAME + green tea (200 mg/kg) [34][35][36], respectively. After two weeks, the rats' heart rates (HR), SBP, DBP, and mean arterial pressure (MAP) were measured up to 24 h and on the 16th day, amlodipine (1 mg/kg, oral single dose) was given to Group 2, Group 3, and Group 4, and blood pressure was again measured up to 24 h [37][38][39][40][41][42][43]. After the washout duration of 3 days, a once-daily oral dose of the drug (amlodipine 1 mg/kg) was given again, and samples of blood were drawn at predetermined intervals for a period of 24 h. The plasma sample was then separated from blood samples and analyzed for drug concentrations using the "UPLC (ultra-performance liquid chromatography)-MS/MS method".…”

Section: Monitoring Rat Blood Pressure and Pharmacokinetic Studymentioning

confidence: 99%

Impact of Cumin and Green Tea on Amlodipine Pharmacodynamics and Pharmacokinetics in Hypertensive Rats

Abdelrahman,

Ahad,

Raish

et al. 2023

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The main purpose of the current research was to determine the impact of cumin and green tea on the pharmacodynamics and pharmacokinetics of amlodipine in hypertensive rats. Wistar rats were given 40 mg/kg of L-NAME orally every day for two weeks in order to induce hypertension. The groups treated with herbs received L-NAME with a daily oral dose of cumin (200 mg/kg) and green tea (200 mg/kg), respectively. After the treatment for 14 days, blood pressure was measured at specific intervals using a tail-cuff BP-measurement device for 24 h. For oral pharmacokinetics of amlodipine (single dose, 1 mg/kg), the blood samples were collected at predetermined intervals up to 24 h, and plasma samples were analyzed using UPLC-LC MS/MS. In comparison to the hypertensive control group, green tea and cumin significantly decreased systolic and diastolic blood pressures, as well as mean arterial pressures. Green tea has demonstrated a more prominent effect on pharmacodynamic of amlodipine compared to cumin. The rats treated with amlodipine, cumin + amlodipine, and green tea + amlodipine exhibited AUC0-t of 38.85 ± 14.8 ng h/mL, 52.05 ± 10.2 ng h/mL, and 114.73 ± 24.94 ng h/mL, respectively. In addition, it has been observed that co-administration of green tea and cumin increases the Cmax and T1/2 of amlodipine. The results indicated a potential interaction between amlodipine and the investigated herbs in hypertensive rats. Hence, precautions should be taken while concurrently administrating amlodipine with the investigated herbs.

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Section: Monitoring Rat Blood Pressure and Pharmacokinetic Studymentioning

confidence: 99%

Impact of Cumin and Green Tea on Amlodipine Pharmacodynamics and Pharmacokinetics in Hypertensive Rats

Abdelrahman,

Ahad,

Raish

et al. 2023

Separations

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“…SBP was significantly reduced to an average of 145.57 2.6 mmHg as a result of co-administration with amlodipine, a drop of 15.48% when compared to the hypertensive control group. Cinnamon consumption significantly lowers BP levels in hypertensive rats and improves the PK characteristics of amlodipine [ 238 ]. Although it is used in food preparation for flavor and taste, cinnamon may also play a part in the regulation of BP and glucose metabolism.…”

Section: Medicinal Plants and Their Bioactive Compounds Having Hypote...mentioning

confidence: 99%

Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies

Islam,

Dhar,

Akash

et al. 2023

Nat. Prod. Bioprospect.

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Hypertension (HTN), a complex cardiovascular disease (CVD), significantly impacts global health, prompting a growing interest in complementary and alternative therapeutic approaches. This review article seeks to provide an up-to-date and thorough summary of modern therapeutic techniques for treating HTN, with an emphasis on the molecular mechanisms of action found in substances found in plants, herbs, and seafood. Bioactive molecules have been a significant source of novel therapeutics and are crucial in developing and testing new HTN remedies. Recent advances in science have made it possible to understand the complex molecular mechanisms underlying blood pressure (BP)-regulating effects of these natural substances better. Polyphenols, flavonoids, alkaloids, and peptides are examples of bioactive compounds that have demonstrated promise in influencing several pathways involved in regulating vascular tone, reducing oxidative stress (OS), reducing inflammation, and improving endothelial function. The article explains the vasodilatory, diuretic, and renin–angiotensin–aldosterone system (RAAS) modifying properties of vital plants such as garlic and olive leaf. Phytochemicals from plants are the primary in traditional drug development as models for novel antihypertensive drugs, providing diverse strategies to combat HTN due to their biological actions. The review also discusses the functions of calcium channel blockers originating from natural sources, angiotensin-converting enzyme (ACE) inhibitors, and nitric oxide (NO) donors. Including seafood components in this study demonstrates the increased interest in using bioactive chemicals originating from marine sources to treat HTN. Omega-3 fatty acids, peptides, and minerals obtained from seafood sources have anti-inflammatory, vasodilatory, and antioxidant properties that improve vascular health and control BP. Overall, we discussed the multiple functions of bioactive molecules and seafood components in the treatment of HTN.

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Inhibitory effects of cuminaldehyde on human liver cytochrome P450 enzymes

Alharbi,

Ahad,

Bin Jardan

et al. 2024

Journal of King Saud University - Science

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Cinnamon modulates the pharmacodynamic & pharmacokinetic of amlodipine in hypertensive rats

Cited by 4 publications

References 52 publications

Impact of Cumin and Green Tea on Amlodipine Pharmacodynamics and Pharmacokinetics in Hypertensive Rats

Impact of Cumin and Green Tea on Amlodipine Pharmacodynamics and Pharmacokinetics in Hypertensive Rats

Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies

Inhibitory effects of cuminaldehyde on human liver cytochrome P450 enzymes

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