2023
DOI: 10.1039/d2fo01835g
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Cinnamon (Cinnamomum cassia) water extract improves diarrhea symptoms by changing the gut environment: a randomized controlled trial

Abstract: Cinnamon water extract was found to slow the colonic transit time of stools and to alter the gut microbiota composition and its metabolites, thereby, alleviating diarrhea symptoms. Metabolic pathways related to gut microbiota were predicted.

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Cited by 6 publications
(5 citation statements)
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“…Taken together, these properties, along with C. cassia antiviral, immunomodulatory, and thrombolytic activities, support the use of this plant as an add-on therapy for Long COVID-19 issues (Singh et al, 2021). This hypothesis is further cor- partially to these effects, indicating potential synergistic effects with other active compounds present in the water extract (Park et al, 2023).…”
Section: Cinnamomum Cassia (Ròu Guì)mentioning
confidence: 60%
See 1 more Smart Citation
“…Taken together, these properties, along with C. cassia antiviral, immunomodulatory, and thrombolytic activities, support the use of this plant as an add-on therapy for Long COVID-19 issues (Singh et al, 2021). This hypothesis is further cor- partially to these effects, indicating potential synergistic effects with other active compounds present in the water extract (Park et al, 2023).…”
Section: Cinnamomum Cassia (Ròu Guì)mentioning
confidence: 60%
“…Additionally, the extract exhibited effects on the levels of biogenic amines, short‐chain fatty acids, and indole in the stool samples of individuals with diarrhea. The presence of coumarin and cinnamic acid likely contributed partially to these effects, indicating potential synergistic effects with other active compounds present in the water extract (Park et al, 2023).…”
Section: The Phytocomplexmentioning
confidence: 99%
“…The branched-chain fatty acid may regulate the immune balance and microinflammation of the mucosa of the gastrointestinal tract [27,28], which also affect intestinal motility and clinical syndrome. A previous study indicated that the intervention relieved diarrhea symptoms by significantly increasing fecal isobutyric acid level and colonic transit time [29]. In addition, they generated for a balance to reduce the pH of the gut and maintain substances with antibacterial effects (such as lipophilic molecules, antibiotics, and hydroperoxides) [30].…”
Section: Discussionmentioning
confidence: 99%
“…Bacteroidetes have various beneficial effects and contribute to improving host metabolism and immune homeostasis. Studies have reported that centenarians have Bacteroidetes-dominant gut microbiota (Pang et al, 2023). Bacteroidetes can produce less toxic LPS, which help reduce LPS-induced inflammatory responses (Magne et al, 2020;Zafar and Saier, 2021).…”
Section: Discussionmentioning
confidence: 99%
“…Notably, Huanglian, Zhishi, Gualou, and Rougui all impact the large intestine meridian. These herbs are commonly employed in traditional herbal medicine for the treatment of gastrointestinal disorders such as abdominal pain, diarrhea, or constipation ( Yang et al, 2021 ; Park et al, 2023 ). Berberine, extracted from Huanglian, is a natural compound extensively used in the management of intestinal diseases, primarily exerting anti-inflammatory and antioxidant effects ( Zhu et al, 2022 ; Cao et al, 2023 ).…”
Section: Introductionmentioning
confidence: 99%