Cinnamon (Cinnamomum zeylanicum) Essential Oils

Cardoso‐Ugarte, Gabriel Abraham; López‐Malo, Aurelio; Sosa‐Morales, María Elena

doi:10.1016/b978-0-12-416641-7.00038-9

Cited by 45 publications

(29 citation statements)

References 19 publications

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“…The essential oil of C. zeylanicum L. bark (EOC) represents a lipophilic extract rich in some monoterpenoids (e.g., α-terpineol, caryophyllene, geraniol, phellandrene, borneol, carvacrol), sesquiterpenoids (e.g., limonene and linalool), with the main part formed by phenylpropanoids cinnamaldehyde, cinnamyl acetate, eugenol, and also simple aromatics such as benzaldehyde [18]. Together with relatively hydrophilic cinnamic acid, tannins, and some flavonoids, these secondary metabolites categorize C. zeylanicum bark amongst the spices and plant foods with the highest overall antioxidant capacity [19].…”

Section: Introductionmentioning

confidence: 99%

Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses

et al. 2020

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Comprehensive oncology research suggests an important role of phytochemicals or whole plant foods in the modulation of signaling pathways associated with anticancer action. The goal of this study is to assess the anticancer activities of Cinnamomum zeylanicum L. using rat, mouse, and cell line breast carcinoma models. C. zeylanicum (as bark powder) was administered in the diet at two concentrations of 0.1% (w/w) and 1% (w/w) during the whole experiment in chemically induced rat mammary carcinomas and a syngeneic 4T1 mouse model. After autopsy, histopathological and molecular evaluations of mammary gland tumors in rodents were carried out. Moreover, in vitro analyses using MCF-7 and MDA-MB-231 cells were performed. The dominant metabolites present in the tested C. zeylanicum essential oil (with relative content over 1%) were cinnamaldehyde, cinnamaldehyde dimethyl acetal, cinnamyl acetate, eugenol, linalool, eucalyptol, limonene, o-cymol, and α-terpineol. The natural mixture of mentioned molecules demonstrated significant anticancer effects in our study. In the mouse model, C. zeylanicum at a higher dose (1%) significantly decreased tumor volume by 44% when compared to controls. In addition, treated tumors showed a significant dose-dependent decrease in mitotic activity index by 29% (0.1%) and 45.5% (1%) in comparison with the control group. In rats, C. zeylanicum in both doses significantly reduced the tumor incidence by 15.5% and non-significantly suppressed tumor frequency by more than 30% when compared to controls. An evaluation of the mechanism of anticancer action using valid oncological markers showed several positive changes after treatment with C. zeylanicum. Histopathological analysis of treated rat tumor specimens showed a significant decrease in the ratio of high-/low-grade carcinomas compared to controls. In treated rat carcinomas, we found caspase-3 and Bax expression increase. On the other hand, we observed a decrease in Bcl-2, Ki67, VEGF, and CD24 expressions and MDA levels. Assessment of epigenetic changes in rat tumor cells in vivo showed a significant decrease in lysine methylation status of H3K4m3 and H3K9m3 in the high-dose treated group, a dose-dependent increase in H4K16ac levels (H4K20m3 was not changed), down-regulations of miR21 and miR155 in low-dose cinnamon groups (miR22 and miR34a were not modulated), and significant reduction of the methylation status of two out of five gene promoters—ATM and TIMP3 (PITX2, RASSF1, PTEN promoters were not changed). In vitro study confirmed results of animal studies, in that the essential oil of C. zeylanicum displayed significant anticancer efficacy in MCF-7 and MDA-MB-231 cells (using MTS, BrdU, cell cycle, annexin V/PI, caspase-3/7, Bcl-2, PARP, and mitochondrial membrane potential analyses). As a conclusion, C. zeylanicum L. showed chemopreventive and therapeutic activities in animal breast carcinoma models that were also significantly confirmed by mechanistic evaluations in vitro and in vivo.

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Section: Introductionmentioning

confidence: 99%

Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses

et al. 2020

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“…The two spices that are usually incorporated in the formulation are cinnamon (Cinnamomun verum) and clove (Syzygium aromaticum). Cinnamon quills, obtained from the central part of tree´s bark, is the product commonly commercialized (59) and contains essential oils such as monoterpenes, alcohols, monoterpene hydrocarbons, acids, aldehydes, phenols, and other compounds as lignas and sterols (9). While cloves contain several volatile oils, mainly eugenol, acetyl eugenol, βcaryophyllene, methyl salicylate, pinene and vanillin whose antibacterial and fungal properties have been demonstrated in several studies (20,40).…”

Section: Factors That Impact the Microbiological Stability Of The Beveragementioning

confidence: 99%

Factors That Affect the Microbiological Stability of Chicha Morada during Its Production on an Industrial Scale: A Review

Guerrero

Flores

Ramos-Gorbeña

et al. 2021

Journal of Food Protection

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“Chicha Morada” also known as purple corn drink (PCD), is a traditional non-carbonated beverage commonly prepared at homes and restaurants in Peru. However, in recent years, it is being produced at an industrial scale aiming to extend its shelf-life, expand its marketing and make it known worldwide. Traditionally, this beverage, main component being purple corn (Zea mays L.), was made and consumed quickly, and in some cases, stored under refrigeration until consumption, but never beyond 24 to 48 hours. With its industrialization, factories are presented with challenges to design and provide adequate protection of the beverage, assuring its quality and safety. Although its production at an industrial level is very similar to other non-carbonated drinks containing fruit juice, several processing factors could affect the microbiological stability desired for this beverage, such as the storage of the purple corn drink extract. In this document, a critical review of the production process (raw materials, production stages and forms of commercialization) that can have a direct impact on the contamination of the beverage was made. Recommendations are made for improving the control points in the industrial process and to avoid potential microbiological problems.

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“…As the Cinnamon gets older, its colour darkens, which improves the resinous compounds. Numerous physiochemical properties of Cinnamon were reported for instance, the presence of a wide variety of essential oils like transcinnamaldehyde, cinnamyl acetate, eugenol, L-borneol, caryophyllene oxide, b-caryophyllene, L-boranyl acetate, E-nerolidol, alpha-terpinol, alpha-cubebene, terpinolene and alpha-thujene (Figure 1) were reported (Cardoso-Ugarte et al, 2016). Mallavarapu et al (1995) studied those 53 constituents which generally includes one of the major components, i.e.…”

Section: Chemical Constituentsmentioning

confidence: 99%

Herbs that heal Spices: The hoard of natural remedies

Alam¹

2019

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Plants and humans have cherished a great association ever since their beginning of this planet. Our planet is called green planet just because of the green boon given to us by Mother Nature. Plants fulfill almost ever y need of humans and other life present on this planet. Through finely woven ecosystems with well formed trophic levels, humans are getting precious offering in the form of plants, including their food, feed, shelter and most significantly the medicines to cure various ailments. In this review an attempt has been made to highlight just only three common kitchen's spices that have valuable aspects as medicinal herbs, viz., Cinnamomum verum J. Presl (Dalchini), Trigonella foenum-graecum L. (Methi) and Crocus sativus L. (Kesar). An all inclusive account of these three is given related to their potential as natural medicines.

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Cinnamon (Cinnamomum zeylanicum) Essential Oils

Cited by 45 publications

References 19 publications

Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses

Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses

Factors That Affect the Microbiological Stability of Chicha Morada during Its Production on an Industrial Scale: A Review

Herbs that heal Spices: The hoard of natural remedies

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