Cinnamomum tamala as an adjuvant therapy in the treatment of major depressive disorder: A double-blind, randomized, placebo-controlled clinical trial with placebo control

Ghaffari, Salomeh; Ghobadi, Ali; Jamshidi, A H; Mortazavi, Seyyed Hosein; Naderi, Sina; Aqamolaei, Ali; Mortezaei, Amirhosein; Sahebolzamani, Erfan; Shamabadi, Ahmad; Jalilvand, Shakiba; Daraei, Bahram; Shalbafan, Mohammad Reza; Akhondzadeh, Shahin

doi:10.1016/j.aimed.2019.12.002

Cited by 5 publications

(7 citation statements)

References 37 publications

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“…A signification proportion of patients across the world are turning to TCM as a cost-effective form of treatment [ 12 , 45 ]. Numerous studies have shown the important role of these therapies in the treatment of various diseases [ 53 - 56 ]. In contrast, very few studies have explored the role of TCM, especially PM, in the prevention and treatment of life-threatening diseases that need immediate care [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Bloodletting and Cupping in Severe Acute Urticaria and Angioedema as Skin Emergencies in Persian Medicine

2022

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Objectives Some dermatological diseases can be life-threatening. Urticaria and angioedema are common reasons for patients to seek treatment at an emergency department. Severe, generalized urticaria and angioedema can endanger patients’ lives by involving the airways and causing anaphylactic shock. The humor-based Persian Medicine (PM) concepts of Shara and Mashara , referring to two kinds of skin lesions, have similarities to urticaria and angioedema, respectively. This article aims to provide scientific evidence regarding the application of PM as an early intervention strategy in the emergency management of urticaria and angioedema. Methods This was a narrative review of PM studies identified by searching medical databases using search terms related to these diseases, as well as risk-associated keywords such as “fatal”, “death”, “life-threatening”, “emergency”, “cupping”, and “bloodletting”. Data were then compared, interpreted, and analyzed. Results PM scholars consider the human body as a unified whole and believe in an inner power (Nature) which stems from the body. When the presence of excessive hot substances cause an imbalance of bodily humors, Nature directs their heated vapors sharply toward the skin, thus causing Shara and Mashara . If there is a high risk of inflammation spreading to vital organs under severe conditions, urgent manual interventions are crucial. Conclusion In serious conditions of urticaria and angioedema, Fasd or bloodletting and Hijama can be effective in speeding up the control of lesions and reducing morbidity and mortality. Consequently, the development of integrated Persian and conventional medicines may provide new therapeutic pathways for skin emergencies.

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Section: Discussionmentioning

confidence: 99%

The Role of Bloodletting and Cupping in Severe Acute Urticaria and Angioedema as Skin Emergencies in Persian Medicine

2022

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“…Despite many studies, this field still needs the attention of researchers. Cinnamomum tamala 500 mg daily 106 Not rejecting items is due to the lack of a systematic search. CANMAT Canadian Network for Mood and Anxiety Treatments.…”

Section: Discussionmentioning

confidence: 99%

“…105 The antidepressant effect of Cinnamomum tamala was evaluated in a trial designed by Ghaffari et al In this clinical trial, Cinnamomum tamala, at a daily dose of 500 mg in combination with sertraline, was reported to be effective in the treatment of MDD. 106 Further trials by researchers in high-quality studies and larger sample sizes are recommended to investigate the antidepressant effect of Cinnamomum tamala and its mechanism.…”

Section: Hypericum Perforatummentioning

confidence: 99%

Advances in Alternative and Integrative Medicine in the Treatment of Depression: A Review of the Evidence

Shamabadi

Akhondzadeh

2021

Arch Iran Med

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Depression is a chronic and debilitating psychiatric disorder that affects 300 million people worldwide. Pharmacotherapy is one of the treatments. Due to delay in initiating treatment efficacy and the incomplete response to mono-drug therapy in onethird of patients, new approaches need to be considered. One of the ways to overcome this resistance to treatment and to enhance standard medical practice is to add complementary medicines. We aimed to document research progress from studies on integrative medicine for the treatment of depression. Review of PubMed and Scopus databases on the topic and a personal collection of the relevant publications are the sources for this study. Some of the nutraceuticals and complementary medicines in the treatment of depression will be reviewed. Supplements discussed in this review include S-adenosyl-methionine (SAMe), Crocus sativus (Saffron), carnosine, theanine, palmitoylethanolamide (PEA), tryptophan and 5-hydroxytryptophan (5-HTP), gemfibrozil, curcumin (the main active ingredient in turmeric), Hypericum perforatum (St John's wort), Lavandula angustifolia (Lavender), and Cinnamomum tamala. Despite evidence in favor of the antidepressant effect of several supplements, their efficacy and tolerability should be evaluated and validated by further high-quality studies.

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“…The secondary outcome measure was Y-BOCS compulsion and obsession subscale score changes between two groups during the trial period, and also the complete response, partial response, and remission rates, de ned as ⩾35%, ⩾25% decrease in, and ⩽16 Y-BOCS total scores (30). Moreover, adverse effects were monitored every four weeks using a systematic questionnaire and three open questions to include any other side effects not included in the questionnaire (31)(32)(33). In case of observation of any serious adverse effects during the course of therapy,…”

Section: Interventionsmentioning

confidence: 99%

Granisetron Augmentation of Sertraline in Obsessive-Compulsive Disorder: A Double-Blind Placebo-Controlled, Randomized Clinical Trial

Ghobadian

Mokhtari

Shariati

et al. 2022

Preprint

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Background: Medications currently recommended for the treatment of Obsessive-Compulsive Disorder (OCD) usually relieve the severity of symptoms by as much as 20–30%, and satisfactory treatment is obtained in 40–60% of patients with OCD. Nevertheless, the remaining symptoms continue to impair the patients’ function. Therefore, it is necessary to investigate possible strategies to improve the mitigation of symptoms.In this study, the main objective was to examine and investigate the effectiveness of granisetron, which is a serotonin 5-hydroxytryptamine receptor type 3 (5-HT3) antagonist, as an adjunct therapy to selective serotonin reuptake inhibitors, for the purpose of ameliorating OCD symptoms. Methods: fifty-eight patients diagnosed with OCD, based on Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, who had a Yale-Brown obsessive-compulsive scale (Y-BOCS) score of more than 21 were recruited in a double-blinded, parallel-group, placebo-controlled, clinical trial of 10 weeks to receive either granisetron (1 mg twice daily) and sertraline (100 mg daily initially followed by 200 mg daily after week 4) or placebo and sertraline. The primary outcome was OCD symptoms measured by the Y-BOCS.Results: Y-BOCS total score significantly dropped in both groups (28.9 to 17.7 for granisetron and 27.5 to 19.3 for placebo group with a slightly greater drop for granisetron group), while the granisetron group experienced a significantly greater reduction in obsession scores (Greenhouse-Geisser F(2.32,97.57)=4.52,p-value=0.01). Moreover, in comparison with the placebo group, the proportion of the patients showing complete response was considerably higher among the granisetron group (P-value <0.01). No major adverse effects were observed in any of the groups. Conclusion: The results suggest that granisetron augmentation of sertraline may increase the rate of response in patients with moderate to severe non-refractory OCD. Further studies are suggested in this regard.Trial registration: The trial was registered at the Iranian Registry of Clinical Trials on 27/03/2019 (www.irct.ir; IRCT ID: IRCT20170123032145N3).

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Cinnamomum tamala as an adjuvant therapy in the treatment of major depressive disorder: A double-blind, randomized, placebo-controlled clinical trial with placebo control

Cited by 5 publications

References 37 publications

The Role of Bloodletting and Cupping in Severe Acute Urticaria and Angioedema as Skin Emergencies in Persian Medicine

The Role of Bloodletting and Cupping in Severe Acute Urticaria and Angioedema as Skin Emergencies in Persian Medicine

Advances in Alternative and Integrative Medicine in the Treatment of Depression: A Review of the Evidence

Granisetron Augmentation of Sertraline in Obsessive-Compulsive Disorder: A Double-Blind Placebo-Controlled, Randomized Clinical Trial

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