Cinnamaldehyde-Contained Polymers and Their Biomedical Applications

Abstract

Cinnamaldehyde, a natural product that can be extracted from a variety of plants of the genus Cinnamomum, exhibits excellent biological activities including antibacterial, antifungal, anti-inflammatory, and anticancer properties. To overcome the disadvantages (e.g., poor water solubility and sensitivity to light) or enhance the advantages (e.g., high reactivity and promoting cellular reactive oxygen species production) of cinnamaldehyde, cinnamaldehyde can be loaded into or conjugated with polymers for sustained or controlled release, thereby prolonging the effective action time of its biological activities. Moreover, when cinnamaldehyde is conjugated with a polymer, it can also introduce environmental responsiveness to the polymer through the form of stimuli-sensitive linkages between its aldehyde group and various functional groups of polymers. The environmental responsiveness provides the great potential of cinnamaldehyde-conjugated polymers for applications in the biomedical field. In this review, the strategies for preparing cinnamaldehyde-contained polymers are summarized and their biomedical applications are also reviewed.

Spice-Derived Phenolic Compounds: Potential for Skin Cancer Prevention and Therapy

“…Apart from its culinary applications, cinnamaldehyde has gained attention for its potential health benefits. Studies have suggested that it may have antioxidant, anti-inflammatory, and anticancer properties [393][394][395].…”

Fabrication and Evaluation of a Soy Protein Isolate/Collagen/Sodium Alginate Multifunctional Bilayered Wound Dressing: Release of Cinnamaldehyde, Artemisia absinthium, and Oxygen

“…To further augment the therapeutic potential of the hydrogel, the formulation incorporates cinnamaldehyde, a compound derived from cinnamon bark known for its antimicrobial and anti-inflammatory properties. Cinnamaldehyde has shown promise in preventing infection and reducing inflammation, critical factors that can impede the natural course of wound healing. , The inclusion of this natural compound aims to create a hostile environment for pathogens while simultaneously promoting an anti-inflammatory response, fostering an ideal milieu for tissue repair.…”

“…Cinnamaldehyde has shown promise in preventing infection and reducing inflammation, critical factors that can impede the natural course of wound healing. 15,16 The inclusion of this natural compound aims to create a hostile environment for pathogens while simultaneously promoting an anti-inflammatory response, fostering an ideal milieu for tissue repair.…”

Trans-Cinnamaldehyde Inhibition of Pyruvate Dehydrogenase: Effects on Streptococcus mutans Carbohydrate Metabolism

“…Many naturally occurring drugs such as terpenoids, essential oils, and flavonoids have been shown to disrupt biofilm assembly and/or reduce EPS synthesis. − Trans- cinnamaldehyde (CA), an α,β-unsaturated aromatic aldehyde, is the main component of cinnamon essential oil in China . It has been widely used in food, cosmetics, and other industries, and its anti-inflammatory, antioxidant, and antibacterial properties have been demonstrated. − Previous studies have shown that CA has a wide antimicrobial spectrum, active against Salmonella typhimurium, Staphylococcus aureus (S. aureus), Escherichia coli (E.…”