Cingulum White Matter in Young Women at Risk of Depression: The Effect of Family History and Anhedonia

Keedwell, Paul Anthony; Chapman, Rosanna; Christiansen, Kat; Richardson, Heather; Evans, John; Jones, Derek K.

doi:10.1016/j.biopsych.2012.01.022

Cited by 101 publications

(79 citation statements)

References 52 publications

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“…Architectural deficits in the cingulum could represent a diathesis for the development of psychopathology that may, in part, be mediated by genetic makeup. Consistent with this hypothesis, earlier studies of psychiatrically healthy youths with variable family histories of depression (Huang et al, 2011) and major depressive disorder (Keedwell et al, 2012), have revealed significantly lower cingulum FA in at-risk groups. Given the growing evidence indicating that white matter development is under the influence of genetic control (Chiang et al, 2009;Kochunov et al, 2010), it is possible that the lower cingulum FA observed in our sample of individuals with PTSD represents a biological marker of genetic risk for this disorder.…”

Section: Discussionsupporting

confidence: 69%

White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder

Fani

King

Jovanović

et al. 2012

Neuropsychopharmacol

113

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Prior structural imaging studies of post-traumatic stress disorder (PTSD) have observed smaller volumes of the hippocampus and cingulate cortex, yet little is known about the integrity of white matter connections between these structures in PTSD samples. The few published studies using diffusion tensor imaging (DTI) to measure white matter integrity in PTSD have described individuals with focal trauma rather than chronically stressed individuals, which limits generalization of findings to this population; in addition, these studies have lacked traumatized comparison groups without PTSD. The present DTI study examined microstructural integrity of white matter tracts in a sample of highly traumatized African-American women with (n ¼ 25) and without (n ¼ 26) PTSD using a tract-based spatial statistical approach, with threshold-free cluster enhancement. Our findings indicated that, relative to comparably traumatized controls, decreased integrity (measured by fractional anisotropy) of the posterior cingulum was observed in participants with PTSD (po0.05). These findings indicate that reduced microarchitectural integrity of the cingulum, a white matter fiber that connects the entorhinal and cingulate cortices, appears to be associated with PTSD symptomatology. The role of this pathway in problems that characterize PTSD, such as inadequate extinction of learned fear, as well as attention and explicit memory functions, are discussed.

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Section: Discussionsupporting

confidence: 69%

White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder

Fani

King

Jovanović

et al. 2012

Neuropsychopharmacol

113

View full text Add to dashboard Cite

show abstract

“…Cingulum projects from the cingulate gyrus to the entorhinal cortex, runs arching around the corpus callosum and ensures the communication between the components of the limbic system. That neural bundle integrates disparate systems involved in emotion, attention and memory [16,29,35]. It has been used as a target for lesion in psychoneurosurgery, it has also been stimulated in intractable pain syndromes [11,46].…”

Section: Discussionmentioning

confidence: 99%

Quantification of white matter fibre pathways disruption in frontal transcortical approach to the lateral ventricle or the interventricular foramen in diffusion tensor tractography

et al. 2014

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“…However, all RD participants reported a history of psychotherapeutic treatment (3.0 years on average) and 46% received psychotherapy at the time of MRI assessment, indicating that the variable "coping style" might have been subject to change. In addition to coping styles, reduced pgACC activity might also be related to anhedonia, a trait associated with ACC alterations regarding white matter microstructure (in individuals at risk for MDD [14] ) and resting activity [58] . However, anhedonia scores (calculated using a 3-factor solution of the BDI [59] ) did not explain any variance in our analyses performed with behavioral and fMRI data.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study found the inability to experience positive emotions, anhedonia, to be associated with altered ACC white matter microstructure and positive family history of depression in healthy individuals [14] . Beside the reduced capacity for pleasure as a key symptom of MDD, other facets of disturbed emotional experience such as feelings of emotional emptiness (often described as "feeling numb" or "not being able to feel anything at all") or strong experiences of fear are frequently reported.…”

Section: Introductionmentioning

confidence: 99%

Music in depression: Neural correlates of emotional experience in remitted depression

Aust

Filip²,

Koelsch³

et al. 2013

WJP

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AIM:To investigate neural and behavioral correlates of emotional experiences as potential vulnerability markers in remitted depression. METHODS:Fourteen remitted participants with a history of major depression and fourteen closely matched healthy control participants took part in the study. We used two psychiatric interviews (Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale) and one self-report scale (Beck Depression Inventory) to assess remission. Healthy control participants were interviewed by an experienced psychiatrist to exclude those who showed any current or lifetime psychiatric or neurological disorders. To explore psychosocial and cognitive-interpersonal underpinnings of potential vulnerability markers of depression, early life stress, coping styles and alexithymia were also assessed. We induced pleasant and unpleasant emotional states using congruent combinations of music and human emotional faces to investigate neural and behavioral correlates of emotional experiences; neutral stimuli were used as a control condition. Brain responses were recorded using functional magnetic resonance imaging. Behavioral responses of pleasantness, arousal, joy and fear were measured via button-press inside the resonance imaging scanner. RESULTS:The mean age of the sample was 54.9 (± 11.3) years. There were no differences between remitted depressed (RD) (n = 14; 9 females and 5 males) and healthy participants (n = 14; 8 females and 6 males) regarding age, current degree of depression, early life stress, coping styles and alexithymia. On a neural level, RD participants showed reduced activations in the pregenual anterior cingulate cortex (pgACC) in response to pleasant [parameter estimates: -0.78 vs 0.32; t (26) CONCLUSION:The present study indicates that, in euthymic individuals, depression history alters neural correlates, but not the subjective dimension of pleasant and unpleasant emotional experiences. BRIEF ARTICLE

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Cingulum White Matter in Young Women at Risk of Depression: The Effect of Family History and Anhedonia

Cited by 101 publications

References 52 publications

White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder

White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder

Quantification of white matter fibre pathways disruption in frontal transcortical approach to the lateral ventricle or the interventricular foramen in diffusion tensor tractography

Music in depression: Neural correlates of emotional experience in remitted depression

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