Cinemicrographic Observations of the Effects of Contrast Media On the Microcirculation

Brown, Richard W.; Cr, Youmans; G, Livanec; Derrick,; Tp, Bond; Mm, Guest

doi:10.1177/153857446800200206

Cited by 17 publications

(2 citation statements)

References 24 publications

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“…Speculating upon the microcirculatory effects of various types of contrast media, it should be remembered that besides their aggregating or disaggregating effect these hypertonic media rigidify red cells. This rigidification decreases their rate of passage through pores having the same diameter as capillaries (2,5,10), and may be the cause of microcirculatory disturbances, e.g., rapidly reversible, microscopically demonstrable, precapillary stasis (7,11,15).…”

Section: Discussionmentioning

confidence: 99%

Effect of Ionic and Non-Ionic Contrast Media on Aggregation of Red Blood Cells in Vitro

Raininko¹,

Ylinen²

1987

Acta Radiol

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Fresh human blood without additives, and contrast medium were mixed and examined immediately by light microscopy in a non-flowing state. Sodium meglumine diatrizoate, meglumine diatrizoate, meglumine iodamide, sodium meglumine ioxaglate, iopromide, iopamidol, iohexol, and metrizamide were tested in concentrations of 300 rng IImI. Physiologic saline and 5 % glucose were used as controls. All media were tested in a randomized order with blood samples from 23 volunteers. No aggregation was detected in physiologic saline, and few rouleaux were found in ionic contrast media. Irregular red cell aggregates were found in all low-osmolal contrast media: in 17 per cent of the specimens in ioxaglate, in 52 per cent in metrizamide, and in 78 to 100 per cent in other non-ionic media. Irregular aggregates were seen in all specimens with glucose. It remains to be demonstrated whether or not the irregular aggregation of human red cells in non-ionic contrast media has clinical significance. Iohexol was also tested with blood samples from several laboratory animals, but in nearly every case no aggregates were found. Results of animal experiments or tests with animal blood seem to be poorly applicable to man.

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Section: Discussionmentioning

confidence: 99%

Effect of Ionic and Non-Ionic Contrast Media on Aggregation of Red Blood Cells in Vitro

Raininko¹,

Ylinen²

1987

Acta Radiol

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“…At least, three pathogenetic mechanisms might explain the occur rence of acute renal failure following radiocontrast stud ies in diabetic individuals. Diabetic persons evince: (1) hyperviscosity of blood which can prompt blood stasis in capillary and postcapillary venules resulting in hypoxia and formation of microthrombi [26]: (2) impaired eryth rocyte deformability which may reduce blood How in the renal microcirculation causing renal ischemia, a known risk factor for acute renal failure [27], and (3) abnormal platelet aggregation contributing to the genesis of macroand microangiopathy [28]. Additionally, arteriosclerosis of afferent and efferent glomerular arterioles may predis pose the diabetic individual to renal injury.…”

Section: Discussionmentioning

confidence: 99%

Uninephrectomy Does Not Potentiate Contrast Media Nephrotoxicity in the Streptozotocin-Induced Diabetic Rat

Shyh

Friedman

1990

Nephron

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We studied the effect of radiographic contrast media on renal function in both streptozotocin-induced diabetic rats and normoglycemic rats with reduced renal functional mass. Male Sprague-Dawley induced-diabetic rats and weight-matched controls were divided into unilaterally nephrectomized and intact groups prior to an intravenous challenge with sodium diatrizoate (Urografin) at two dose levels, 1,300 and 2,600 mg iodine/kg. Serum creatinine concentration did not change on the 1st and 3rd day after a dose of 1,300 mg/kg of iodine in normal or induced-diabetic rats. Consequent to a dose of 2,600 mg/kg of iodine, induced-diabetic rats had a significant increase in serum creatinine levels to 0.9 ± 0.45 mg/dl (control 0.68 ± 0.11 mg/dl). The observed increase in serum creatinine concentration after treatment with sodium diatrizoate was significantly correlated with the degree of hyperglycemia, but not with prior unilateral nephrectomy. Unilateral nephrectomy, prior to administration of sodium diatrizoate did not potentiate the risk of radiocontrast agent injury in induced-diabetic rats. From these findings, we infer that: (1) streptozotocin-induced diabetes in the rat confers a risk for the development of radiocontrast-induced acute renal failure and (2) as judged by the rise in serum creatinine concentration after exposure, there is an increased risk of acute renal failure associated with a higher dose of radiocontrast material.

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Contrast Media Induced Nephropathy in Diabetic Nephropathy

Manis¹,

Friedman²

1988

The Kidney and Hypertension in Diabetes Mellitus

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Cinemicrographic Observations of the Effects of Contrast Media On the Microcirculation

Cited by 17 publications

References 24 publications

Effect of Ionic and Non-Ionic Contrast Media on Aggregation of Red Blood Cells in Vitro

Effect of Ionic and Non-Ionic Contrast Media on Aggregation of Red Blood Cells in Vitro

Uninephrectomy Does Not Potentiate Contrast Media Nephrotoxicity in the Streptozotocin-Induced Diabetic Rat

Contrast Media Induced Nephropathy in Diabetic Nephropathy

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